Bendamustine
- Generic Name
- Bendamustine
- Brand Names
- Belrapzo, Bendeka, Treanda, Vivimusta
- Drug Type
- Small Molecule
- Chemical Formula
- C16H21Cl2N3O2
- CAS Number
- 16506-27-7
- Unique Ingredient Identifier
- 9266D9P3PQ
- Background
Bendamustine is a nitrogen mustard drug indicated for use in the treatment of chronic lymphocytic leukemia (CLL) and indolent B-cell non-Hodgkin lymphoma (NHL) that has progressed during or within six months of treatment with rituximab or a rituximab-containing regimen. Bendamustine is a bifunctional mechlorethamine derivative capable of forming electrophilic alkyl groups that covalently bond to other molecules. Through this function as an alkylating agent, bendamustine causes intra- and inter-strand crosslinks between DNA bases resulting in cell death. It is active against both active and quiescent cells, although the exact mechanism of action is unknown.
- Indication
Bendamustine is indicated for use in the treatment of chronic lymphocytic leukemia (CLL) and indolent B-cell non-Hodgkin lymphoma (NHL) that has progressed during or within six months of treatment with rituximab or a rituximab-containing regimen.
- Associated Conditions
- Chronic Lymphocytic Leukemia, Follicular Non-Hodgkin's Lymphoma Refractory, Refractory Hodgkin Lymphoma, Refractory Mantle Cell Lymphoma, Waldenström's Macroglobulinemia (WM), Recurrent multiple myeloma, Refractory indolent B cell non-hodgkin lymphoma
Bendamustine With or Without Cyclophosphamide in Preventing GVHD in Patients Undergoing Stem Cell Transplant
- Conditions
- Hematopoietic and Lymphoid System Neoplasm
- Interventions
- Procedure: Allogeneic Hematopoietic Stem Cell TransplantationRadiation: Total-Body Irradiation
- First Posted Date
- 2019-07-17
- Last Posted Date
- 2025-05-18
- Lead Sponsor
- M.D. Anderson Cancer Center
- Target Recruit Count
- 25
- Registration Number
- NCT04022239
- Locations
- 🇺🇸
M D Anderson Cancer Center, Houston, Texas, United States
A Study to Investigate the Efficacy of Zanubrutinib Plus Rituximab Compared With Bendamustine Plus Rituximab in Adults With Previously Untreated Mantle Cell Lymphoma Who Are Ineligible for Stem Cell Transplantation
- Conditions
- Mantle Cell Lymphoma; Non-Hodgkin Lymphoma
- Interventions
- First Posted Date
- 2019-06-28
- Last Posted Date
- 2025-02-21
- Lead Sponsor
- BeiGene
- Target Recruit Count
- 510
- Registration Number
- NCT04002297
- Locations
- 🇺🇸
West Penn Hospital, Pittsburgh, Pennsylvania, United States
🇨🇳Beijing Friendship Hospital, Capital Medical University, Beijing, Beijing, China
🇨🇳Fujian Medical University Union Hospital, Fuzhou, Fujian, China
Compassionate Use Re-Infusion of ATLCAR.CD30
- Conditions
- Hodgkin Lymphoma, Adult
- First Posted Date
- 2019-04-16
- Last Posted Date
- 2021-12-03
- Lead Sponsor
- UNC Lineberger Comprehensive Cancer Center
- Registration Number
- NCT03914885
- Locations
- 🇺🇸
Lineberger Comprehensive Cancer Center at University of North Carolina, Chapel Hill, North Carolina, United States
Phase I/II Study of SyB L-0501RI in Combination With Rituximab to Treat Lymphoma
- First Posted Date
- 2019-04-03
- Last Posted Date
- 2023-11-24
- Lead Sponsor
- SymBio Pharmaceuticals
- Target Recruit Count
- 37
- Registration Number
- NCT03900377
- Locations
- 🇯🇵
Research Site, Yamagata, Japan
Bendamustine, Obinutuzumab, and Venetoclax in Patients With Untreated Mantle Cell Lymphoma
- Conditions
- Mantle Cell Lymphomat(11;14) PositiveCCND1 Positive
- Interventions
- First Posted Date
- 2019-03-13
- Last Posted Date
- 2024-03-21
- Lead Sponsor
- Emory University
- Target Recruit Count
- 23
- Registration Number
- NCT03872180
- Locations
- 🇺🇸
Emory University Hospital/Winship Cancer Institute, Atlanta, Georgia, United States
🇺🇸Emory Saint Joseph's Hospital, Atlanta, Georgia, United States
🇺🇸Emory Johns Creek Hospital, Johns Creek, Georgia, United States
Inotuzumab Ozogamicin and Chemotherapy in Treating Patients With Leukemia or Lymphoma Undergoing Stem Cell Transplantation
- Conditions
- Acute Lymphoblastic LeukemiaB Acute Lymphoblastic LeukemiaLymphocytic NeoplasmLymphoma
- Interventions
- Procedure: Allogeneic Bone Marrow TransplantationProcedure: Peripheral Blood Stem Cell Transplantation
- First Posted Date
- 2019-02-27
- Last Posted Date
- 2025-04-01
- Lead Sponsor
- M.D. Anderson Cancer Center
- Target Recruit Count
- 44
- Registration Number
- NCT03856216
- Locations
- 🇺🇸
M D Anderson Cancer Center, Houston, Texas, United States
Phase II Study of Bendamustine and Rituximab Plus Venetoclax in Untreated Mantle Cell Lymphoma Over 60 Years of Age
- Conditions
- Mantle Cell Lymphoma
- Interventions
- First Posted Date
- 2019-02-08
- Last Posted Date
- 2024-08-28
- Lead Sponsor
- PrECOG, LLC.
- Target Recruit Count
- 33
- Registration Number
- NCT03834688
- Locations
- 🇺🇸
Carle Cancer Center, Urbana, Illinois, United States
🇺🇸Indiana University Simon Cancer Center, Indianapolis, Indiana, United States
🇺🇸Mayo Clinic, Rochester, Minnesota, United States
An Open-Label, Single Arm Study of Obinutuzumab Short Duration Infusion in Patients With Previously Untreated Advanced Follicular Lymphoma
- Conditions
- Advanced Follicular Lymphoma
- Interventions
- Drug: Prednisone/Prednisolone/Methylprednisolone
- First Posted Date
- 2019-01-28
- Last Posted Date
- 2024-04-04
- Lead Sponsor
- Hoffmann-La Roche
- Target Recruit Count
- 114
- Registration Number
- NCT03817853
- Locations
- 🇳🇱
Albert Schweitzer Ziekenhuis - loc Dordrecht, Dordrecht, Netherlands
🇧🇷NOHC - Núcleo de Oncologia e Hematologia do Ceará, Fortaleza, CE, Brazil
🇺🇸San Juan Oncology Associates, Farmington, New Mexico, United States
Sequential Regimen of Bendamustin-Debulking Followed by Obinutuzumab, Acalabrutinib and Venetoclax in Patients with Relapsed/refractory CLL
- Conditions
- Chronic Lymphoid Leukemia
- Interventions
- First Posted Date
- 2018-12-26
- Last Posted Date
- 2024-12-30
- Lead Sponsor
- German CLL Study Group
- Target Recruit Count
- 46
- Registration Number
- NCT03787264
- Locations
- 🇩🇪
Gemeinschaftspraxis Hämatologie Onkologie, Dresden, Germany
🇩🇪Universitatsklinik Carl Gustav Carus, Dresden, Germany
🇩🇪Praxis fuer Haematologie und Onkologie, Koblenz, Germany
Pediatric Classical Hodgkin Lymphoma Consortium Study: cHOD17
- Conditions
- Hodgkin Lymphoma
- Interventions
- Other: Quality of Life MeasurementsRadiation: Radiotherapy
- First Posted Date
- 2018-11-28
- Last Posted Date
- 2025-02-07
- Lead Sponsor
- St. Jude Children's Research Hospital
- Target Recruit Count
- 250
- Registration Number
- NCT03755804
- Locations
- 🇺🇸
Maine Children's Cancer Program, Scarborough, Maine, United States
🇺🇸St. Jude Affiliate Baton Rouge Clinic (Our Lady of the Lakes Regional Medical Center), Baton Rouge, Louisiana, United States
🇺🇸Massachusetts General Hospital, Boston, Massachusetts, United States
Drug Development Updates
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