Carbetocin

Generic Name: Carbetocin

Brand Names: Duratocin

Drug Type: Small Molecule

Chemical Formula: C_₄₅H_₆₉N_₁₁O_₁₂S

CAS Number: 37025-55-1

Unique Ingredient Identifier: 88TWF8015Y

Background: Carbetocin is a drug used to control postpartum hemorrhage, bleeding after giving birth. It is an analogue of oxytocin, and its action is similar to that of oxytocin -- it causes contraction of the uterus.

Indication: Used to control postpartum hemorrhage and bleeding after giving birth.

Associated Conditions: Postpartum Haemorrhage (PPH), Uterine Atony

Clinical Trials

A Study to Evaluate the Effect of Carbetocin on the QT/QTc Interval in Healthy Subjects

Phase 1

Completed

Conditions: Postpartum Hemorrhage

Interventions: Drug: Placebo
Drug: Placebo and Moxifloxacin
Drug: Carbetocin

First Posted Date: 2023-06-29

Last Posted Date: 2023-09-26

Lead Sponsor: Ferring Pharmaceuticals

Target Recruit Count: 40

Registration Number: NCT05924321

Locations: 🇺🇸
Ferring Investigational Site, Tempe, Arizona, United States

Methods Decreasing Bleeding in Open Myomectomy

Phase 4

Recruiting

Conditions: Oxytocin Allergy
Tranexamic Acid Allergy
Ethamsylate Allergy
Myoma
Blood Loss, Surgical
Misoprostol Allergy

Interventions: Drug: combined TXA and ethamsylate
Device: Tourniquet
Drug: Bupivacaine Hydrochloride 0.5 % Injectable Solution epinephrine
Drug: Misoprostol
Drug: Carbetocin
Drug: Oxytocin
Drug: Vasopressin

First Posted Date: 2023-04-10

Last Posted Date: 2023-04-10

Lead Sponsor: Cairo University

Target Recruit Count: 105

Registration Number: NCT05806307

Locations: 🇪🇬
faculty of medicine, Kasr el ainy hospital, Cairo university, Cairo, Egypt

Carbetocin Compared To Oxytocin During Cesarean Delivery

Not yet recruiting

Conditions: Cesarean Delivery

Interventions: Drug: Carbetocin
Drug: oxytocin

First Posted Date: 2023-03-07

Last Posted Date: 2023-03-07

Lead Sponsor: Assiut University

Target Recruit Count: 260

Registration Number: NCT05758012

Locations: 🇰🇼
Munistery of Health Kuwait, Kuwait, Kuwait

Comparison Of The Effects Of Carbetocin And Oxytocin In C-Sectıon

Phase 4

Not yet recruiting

Conditions: Oxytocic Drugs Causing Adverse Effects in Therapeutic Use
Carbetocin

Interventions: Procedure: C-sections operations
Drug: Carbetocin
Drug: Oxytocin

First Posted Date: 2023-02-24

Last Posted Date: 2023-03-07

Lead Sponsor: Ege University

Target Recruit Count: 200

Registration Number: NCT05742854

Locations: 🇹🇷
EÜTF, Bornova, İ̇zmi̇r, Turkey

Efficacy of Carbetocin Versus Oxytocin Plus Misoprostol in Decreasing Blood Loss During Cesarean Section

Phase 4

Completed

Conditions: Blood Loss, Surgical
Intrapartum Hemorrhage

Interventions: Drug: Oxytocin + misoprostol
Drug: Carbetocin

First Posted Date: 2022-12-27

Last Posted Date: 2023-07-24

Lead Sponsor: Ain Shams Maternity Hospital

Target Recruit Count: 90

Registration Number: NCT05664659

Locations: 🇪🇬
Ain Shams Maternity Hospital, Cairo, Egypt

Carbetocin Versus Oxytocin for Prophylaxis Against Atonic Primary Post-partum Hemorrhage

Not Applicable

Conditions: Atonic Postpartum Hemorrhage
High Risk Pregnancy

Interventions: Drug: Oxytocin
Drug: Carbetocin

First Posted Date: 2022-07-29

Last Posted Date: 2022-08-02

Lead Sponsor: Sohag University

Target Recruit Count: 80

Registration Number: NCT05479357

Efficacy of Four Different Treatment Regimes on Postpartum Hemorrhage

Not Applicable

Completed

Conditions: Postpartum Hemorrhage

Interventions: Drug: I.V Oxytocin administration
Drug: I.V carbetocin and tranexamic acid administration
Drug: I.V carbetocin administration
Drug: I.V Oxytocin and tranexamic acid administration

First Posted Date: 2022-07-20

Last Posted Date: 2023-01-26

Lead Sponsor: Bezmialem Vakif University

Target Recruit Count: 300

Registration Number: NCT05467462

Locations: 🇹🇷
Bezmialem Vakif University, Istanbul, Turkey

The Effect of Intramyometrial Injection of Terlipressin Versus Carbitocin on Hemoglobin and Blood Loss During Open Myomectomy Operations Without Using Haemostatic Tourniquets

Not Applicable

Recruiting

Conditions: Myoma

Interventions: Drug: Carbetocin
Drug: Saline
Drug: Terlipressin

First Posted Date: 2022-03-04

Last Posted Date: 2022-03-04

Lead Sponsor: Wael Elbanna Clinic

Target Recruit Count: 162

Registration Number: NCT05266534

Locations: 🇪🇬
Wael El Banna Clinic, Maadi, Egypt

Carbetocin Versus Syntocinon for Prevention of Postpartum Hemorrhage in Cardiac Patients Undergoing Caesarean Section

Phase 4

Conditions: Adverse Effect of Oxytocic Drugs

Interventions: Drug: Carbetocin
Drug: Syntocinon

First Posted Date: 2021-11-08

Last Posted Date: 2023-06-06

Lead Sponsor: Cairo University

Target Recruit Count: 38

Registration Number: NCT05110482

Locations: 🇪🇬
Faculty of medicine CAIRO UNIVERISTY, Cairo, Egypt

Oxytocin vs Carbetocin at Cesarean Delivery in Women With Morbid Obesity

Not Applicable

Completed

Conditions: Post Partum Hemorrhage

Interventions: Drug: Oxytocin
Drug: Carbetocin

First Posted Date: 2021-05-26

Last Posted Date: 2023-02-23

Lead Sponsor: Samuel Lunenfeld Research Institute, Mount Sinai Hospital

Target Recruit Count: 48

Registration Number: NCT04902729

Locations: 🇨🇦
Mount Sinai Hospital, Toronto, Ontario, Canada

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