Carbetocin

Generic Name: Carbetocin

Brand Names: Duratocin

Drug Type: Small Molecule

Chemical Formula: C_₄₅H_₆₉N_₁₁O_₁₂S

CAS Number: 37025-55-1

Unique Ingredient Identifier: 88TWF8015Y

Background: Carbetocin is a drug used to control postpartum hemorrhage, bleeding after giving birth. It is an analogue of oxytocin, and its action is similar to that of oxytocin -- it causes contraction of the uterus.

Indication: Used to control postpartum hemorrhage and bleeding after giving birth.

Associated Conditions: Postpartum Haemorrhage (PPH), Uterine Atony

Associated Therapies: -

Clinical Trials

Carbetocin Versus Oxytocin in the Prevention of Post Partum Haemorrhage (PPH) in Women Undergoing Caesarean Sections for Placenta Previa: A Randomised Controlled Trial

Phase 3

Conditions: Post Partum Haemorrhage

Interventions: Drug: Carbetocin
Drug: Oxytocin

First Posted Date: 2014-11-27

Last Posted Date: 2017-01-23

Lead Sponsor: Cairo University

Target Recruit Count: 500

Registration Number: NCT02303418

Locations: 🇪🇬
BeniSuef University hospitals, BeniSuef, Egypt
🇪🇬
Cairo university hospitals, Cairo, Egypt

Carbetocin Versus Misoprostol in High Risk Patients for Postpartum Hemorrhage After C.S.

Phase 4

Conditions: Postpartum Hemorrhage

Interventions: Drug: Misoprostol
Drug: Carbetocin

First Posted Date: 2014-10-28

Last Posted Date: 2021-02-02

Lead Sponsor: Beni-Suef University

Target Recruit Count: 200

Registration Number: NCT02277067

Locations: 🇪🇬
Beni-Suef University, Cairo, Egypt

Carbetocin Versus Misoprostol in Cases With Placenta Previa After C.S.

Phase 4

Conditions: Postpartum Hemorrhage

Interventions: Drug: Carbetocin
Drug: Misoprostol

First Posted Date: 2014-10-28

Last Posted Date: 2021-02-02

Lead Sponsor: Beni-Suef University

Target Recruit Count: 200

Registration Number: NCT02277041

Locations: 🇪🇬
Beni-Suef University, Cairo, Egypt

Carbetocin at Elective Cesarean Delivery Part 4

Not Applicable

Completed

Conditions: Postpartum Hemorrhage

Interventions: Drug: Carbetocin

First Posted Date: 2014-10-15

Last Posted Date: 2015-05-27

Lead Sponsor: Samuel Lunenfeld Research Institute, Mount Sinai Hospital

Target Recruit Count: 110

Registration Number: NCT02264769

Locations: 🇨🇦
Mount Sinai Hospital, Toronto, Ontario, Canada

Intramuscular Oxytocics: A Randomised Control Trial

Phase 3

Completed

Conditions: Post Partum Haemorrhage

Interventions: Drug: Syntometrine
Drug: Carbetocin
Drug: Syntocinon

First Posted Date: 2014-08-15

Last Posted Date: 2018-11-14

Lead Sponsor: North Bristol NHS Trust

Target Recruit Count: 5798

Registration Number: NCT02216383

Locations: 🇬🇧
Gloucestershire Hospitals NHS Trust, Gloucester, Gloucestershire, United Kingdom
🇬🇧
Royal United Hospital NHS Trust, Bath, Somerset, United Kingdom
🇬🇧
Great Western Hospital, Swindon, United Kingdom

and more 2 locations

Prevention of Postpartum Hemorrhage in Patients With Severe Preeclampsia Using Carbetocin Versus Misoprostol

Phase 3

Completed

Conditions: Severe Pre-eclampsia, Postpartum Condition or Complication

Interventions: Drug: misoprostol
Drug: carbetocin

First Posted Date: 2014-03-14

Last Posted Date: 2017-02-15

Lead Sponsor: khalid abd aziz mohamed

Target Recruit Count: 60

Registration Number: NCT02086994

Locations: 🇪🇬
Benha univesity hospital, Benha, Egypt

Efficacy of Oxytocin vs. Carbetocin in Prevention of Postpartum Hemorrhage After Cesarean Section

Phase 2

Completed

Conditions: Postpartum Hemorrhage

Interventions: Drug: Oxytocin
Drug: Carbetocin

First Posted Date: 2014-03-06

Last Posted Date: 2014-03-06

Lead Sponsor: Shahid Beheshti University of Medical Sciences

Target Recruit Count: 220

Registration Number: NCT02079558

Locations: 🇮🇷
Infertility and Reproductive Health Research Center, Tehran, Iran, Islamic Republic of

The Use of Oxytocin, Carbetocin and Buccal Misoprostol in Patients Undergoing Elective Cesarean Section (CS)

Phase 3

Completed

Conditions: Postpartum Hemorrhage

Interventions: Drug: Syntocinon
Drug: Carbetocin
Drug: Misoprostol

First Posted Date: 2014-02-04

Last Posted Date: 2014-02-06

Lead Sponsor: Ain Shams University

Target Recruit Count: 270

Registration Number: NCT02053922

Locations: 🇪🇬
Ain Shams Maternity Hospital, Cairo, Egypt

Carbetocin Versus Syntometrine for Prevention of Postpartum Hemorrhage After Cesarean Section

Phase 4

Completed

Conditions: Postpartum Hemorrhage
Blood Loss

Interventions: Drug: Syntometrine
Drug: carbetocin

First Posted Date: 2014-01-24

Last Posted Date: 2021-06-24

Lead Sponsor: Cairo University

Target Recruit Count: 300

Registration Number: NCT02044549

Locations: 🇪🇬
Ahmed Maged, Cairo, Egypt

Analgesic Effect of Oxytocin Receptor Modulation

Not Applicable

Completed

Conditions: Hyperalgesia
Central Sensitization
Pain

Interventions: Drug: Carbetocin
Drug: Placebo

First Posted Date: 2013-08-07

Last Posted Date: 2015-02-12

Lead Sponsor: Insel Gruppe AG, University Hospital Bern

Target Recruit Count: 25

Registration Number: NCT01918475

Locations: 🇨🇭
University Department of Anesthesiology and Pain Therapy, Bern University Hospital, Bern, Switzerland

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