Mifepristone
- Generic Name
- Mifepristone
- Brand Names
- Korlym, Mifegymiso
- Drug Type
- Small Molecule
- Chemical Formula
- C29H35NO2
- CAS Number
- 84371-65-3
- Unique Ingredient Identifier
- 320T6RNW1F
- Background
Mifepristone is a progestational and glucocorticoid hormone antagonist. Its inhibition of progesterone induces bleeding during the luteal phase and in early pregnancy by releasing endogenous prostaglandins from the endometrium or decidua. As a glucocorticoid receptor antagonist, the drug has been used to treat hypercortisolism in patients with nonpituitary c...
- Indication
For the medical termination of intrauterine pregnancy through 49 days' pregnancy. Also indicated to control hyperglycemia secondary to hypercortisolism in adult patients with endogenous Cushing's syndrome who have type 2 diabetes mellitus or glucose intolerance and are not candidates for surgery or have had unsuccessful surgery.
- Associated Conditions
- Hyperglycemia
- Associated Therapies
- Medically induced abortion
Glucocorticoid Receptor Blockade With Mifepristone in Patients With Mild Adrenal Hypercortisolism
- First Posted Date
- 2013-11-21
- Last Posted Date
- 2018-03-02
- Lead Sponsor
- Icahn School of Medicine at Mount Sinai
- Target Recruit Count
- 8
- Registration Number
- NCT01990560
- Locations
- 🇺🇸
Icahn School of Medicine at Mount Sinai, New York, New York, United States
Mifepristone in Children With Refractory Cushing's Disease
- First Posted Date
- 2013-08-19
- Last Posted Date
- 2014-08-04
- Lead Sponsor
- Corcept Therapeutics
- Registration Number
- NCT01925092
- Locations
- 🇺🇸
National Institute of Child Health and Human Development (NICHD), Bethesda, Maryland, United States
Quickstart of Nexplanon® at Medical Abortion
- Conditions
- Interventions
- First Posted Date
- 2013-08-09
- Last Posted Date
- 2016-02-25
- Lead Sponsor
- Karolinska Institutet
- Target Recruit Count
- 551
- Registration Number
- NCT01920022
- Locations
- 🇸🇪
Universitetssjukhuset, Linköping, Sweden
🇸🇪Universitetssjukhuset i Örebro, Örebro, Sweden
🇬🇧Chalmers Sexual and Reproductive Health Service, Edinburgh, United Kingdom
BRCA1/2 and Effect of Mifepristone on the Breast
- Conditions
- Interventions
- First Posted Date
- 2013-07-12
- Last Posted Date
- 2022-01-19
- Lead Sponsor
- Karolinska Institutet
- Target Recruit Count
- 45
- Registration Number
- NCT01898312
- Locations
- 🇸🇪
Department of Woman and Child Health Karolinska University Hospital, Stockholm, Sweden
Pre-Operative Effects of Mifepristone on Dilation and Evacuation Services
- Conditions
- Interventions
- First Posted Date
- 2013-05-27
- Last Posted Date
- 2024-02-14
- Lead Sponsor
- Stanford University
- Target Recruit Count
- 80
- Registration Number
- NCT01862991
- Locations
- 🇺🇸
Stanford University Medical Center, Stanford, California, United States
🇺🇸Santa Clara Valley Medical Center, San Jose, California, United States
Acceptability of an Out-patient Regimen of Medical Abortion With Mifepristone and 800 Mcg Misoprostol Administered at 78-84 Days Gestation
- First Posted Date
- 2013-05-20
- Last Posted Date
- 2013-10-11
- Lead Sponsor
- Gynuity Health Projects
- Target Recruit Count
- 50
- Registration Number
- NCT01856985
- Locations
- 🇻🇳
Hung Vuong Hospital, Ho Chi Minh City, Vietnam
Exploring a Patient-centered Approach to Mifepristone Administration in Medical Abortion
- First Posted Date
- 2013-03-14
- Last Posted Date
- 2015-08-13
- Lead Sponsor
- Gynuity Health Projects
- Target Recruit Count
- 401
- Registration Number
- NCT01811056
- Locations
- 🇺🇸
Planned Parenthood of the Great Northwest, Seattle, Washington, United States
🇺🇸Planned Parenthood of New York City, New York, New York, United States
🇺🇸Planned Parenthood of Northern New England, Barre, Burlington, Rutland, Vermont, United States
Medical Abortion With Mifepristone + Misoprostol (13 - 22 Weeks)
- Conditions
- Interventions
- First Posted Date
- 2013-01-15
- Last Posted Date
- 2014-05-14
- Lead Sponsor
- Gynuity Health Projects
- Target Recruit Count
- 504
- Registration Number
- NCT01768299
- Locations
- 🇻🇳
National Ob-Gyn Hospital, Hanoi, Vietnam
🇻🇳Hung Vuong Hospital, Ho Chi Minh City, Vietnam
🇻🇳Binh duong Obstetrics and Newborn Hospital, Ho Chi Minh City, Binh Duong Province, Vietnam
Mifepristone Versus Misoprostol for Cervical Preparation Prior to Surgical Abortion Between 11 to 15 Weeks
- Conditions
- Interventions
- First Posted Date
- 2012-07-10
- Last Posted Date
- 2017-05-22
- Lead Sponsor
- Boston University
- Target Recruit Count
- 42
- Registration Number
- NCT01636063
- Locations
- 🇺🇸
Boston University Medical Center, Boston, Massachusetts, United States
Pilot Study of Pharmaceutical and Behavioral Interventions to Treat Anxiety Disorders
- Conditions
- Interventions
- First Posted Date
- 2012-06-29
- Last Posted Date
- 2017-02-23
- Lead Sponsor
- Massachusetts General Hospital
- Target Recruit Count
- 186
- Registration Number
- NCT01631682
- Locations
- 🇺🇸
Massachusetts General Hospital, Charlestown, Massachusetts, United States
Drug Development Updates
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