Ifosfamide

Generic Name
Ifosfamide
Brand Names
Ifex
Drug Type
Small Molecule
Chemical Formula
C7H15Cl2N2O2P
CAS Number
3778-73-2
Unique Ingredient Identifier
UM20QQM95Y
Background

Ifosfamide is a chemotherapeutic agent chemically related to the nitrogen mustards and a synthetic analog of cyclophosphamide. It is active as an alkylating agent and an immunosuppressive agent.

Indication

Used as a component of various chemotherapeutic regimens as third-line therapy for recurrent or refractory germ cell testicular cancer. Also used as a component of various chemotherapeutic regimens for the treatment of cervical cancer, as well as in conjunction with surgery and/or radiation therapy in the treatment of various soft tissue sarcomas. Other indi...

Associated Conditions
Bladder Cancer, Cervical Cancer, Ewing's Sarcoma, Head And Neck Cancer, Hodgkin's Lymphoma, Non-Hodgkin's Lymphoma (NHL), Osteosarcoma, Ovarian Cancer, Pancreatic Cancer, Small Cell Lung Cancer (SCLC), Soft Tissue Sarcoma, Testicular Germ Cell Cancer, Thymoma
Associated Therapies
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FaR-RMS: An Overarching Study for Children and Adults With Frontline and Relapsed RhabdoMyoSarcoma

First Posted Date
2020-11-12
Last Posted Date
2024-05-23
Lead Sponsor
University of Birmingham
Target Recruit Count
1672
Registration Number
NCT04625907
Locations
🇬🇷

University Unit of Pediatric Oncology-hematology - Children's Hospital Agia Sophia, Athens, Greece

🇮🇱

Rambam Health Care Campus, Haifa, Israel

🇮🇱

Hadassah University Medical Centre, Jerusalem, Israel

and more 125 locations

TIP (Paclitaxel + Ifosfamide + Cisplatin) Combined With Nimotuzumab & Triprilimab as Neoadjuvant Treatment in Locally Advanced Penile Cancer

First Posted Date
2020-07-17
Last Posted Date
2022-06-09
Lead Sponsor
Sun Yat-sen University
Target Recruit Count
29
Registration Number
NCT04475016
Locations
🇨🇳

Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, China

The Combination of Sintilimab and AI (Doxorubicin, ADM/Ifosfamide, IFO) for the First Line Treatment of Select Type of Metastatic/Unresectable Soft Tissue Sarcoma

First Posted Date
2020-04-22
Last Posted Date
2020-07-14
Lead Sponsor
Fudan University
Target Recruit Count
45
Registration Number
NCT04356872
Locations
🇨🇳

Fudan University, Cancer Hospital, Shanghai, Shanghai, China

High-Risk Neuroblastoma Study 2 of SIOP-Europa-Neuroblastoma (SIOPEN)

First Posted Date
2020-01-09
Last Posted Date
2024-05-16
Lead Sponsor
Gustave Roussy, Cancer Campus, Grand Paris
Target Recruit Count
800
Registration Number
NCT04221035
Locations
🇬🇷

University General Hospital of Thessaloniki "AHEPA", Thessaloniki, Greece

🇬🇷

Children's General Hospital "AGHIA SOFIA", Athens, Greece

🇮🇹

instituto Giannina Gaslini genova, Genova, Italy

and more 134 locations

Acalabrutinib in Combination With R-ICE For Relapsed or Refractory Lymphoma

First Posted Date
2019-12-06
Last Posted Date
2022-09-19
Lead Sponsor
University of Miami
Target Recruit Count
2
Registration Number
NCT04189952
Locations
🇺🇸

University of Miami, Miami, Florida, United States

A Study to Compare the Efficacy and Safety of Ifosfamide and Etoposide With or Without Lenvatinib in Children, Adolescents and Young Adults With Relapsed and Refractory Osteosarcoma

First Posted Date
2019-11-06
Last Posted Date
2024-07-22
Lead Sponsor
Eisai Inc.
Target Recruit Count
81
Registration Number
NCT04154189
Locations
🇺🇸

Loma Linda University Medical Center, Loma Linda, California, United States

🇺🇸

University of Mississippi Medical Center, Jackson, Mississippi, United States

🇺🇸

Hackensack University Medical Center, Hackensack, New Jersey, United States

and more 81 locations
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