Ifosfamide

Generic Name
Ifosfamide
Brand Names
Ifex
Drug Type
Small Molecule
Chemical Formula
C7H15Cl2N2O2P
CAS Number
3778-73-2
Unique Ingredient Identifier
UM20QQM95Y
Background

Ifosfamide is a chemotherapeutic agent chemically related to the nitrogen mustards and a synthetic analog of cyclophosphamide. It is active as an alkylating agent and an immunosuppressive agent.

Indication

Used as a component of various chemotherapeutic regimens as third-line therapy for recurrent or refractory germ cell testicular cancer. Also used as a component of various chemotherapeutic regimens for the treatment of cervical cancer, as well as in conjunction with surgery and/or radiation therapy in the treatment of various soft tissue sarcomas. Other indi...

Associated Conditions
Bladder Cancer, Cervical Cancer, Ewing's Sarcoma, Head And Neck Cancer, Hodgkin's Lymphoma, Non-Hodgkin's Lymphoma (NHL), Osteosarcoma, Ovarian Cancer, Pancreatic Cancer, Small Cell Lung Cancer (SCLC), Soft Tissue Sarcoma, Testicular Germ Cell Cancer, Thymoma
Associated Therapies
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A Study to Evaluate the Efficacy and Safety of a Sintilimab Plus ICE Regimen Versus ICE Regimen in Classic Hodgkin's Lymphoma Patients (cHL) Who Have Failed First-line Standard Chemotherapy

First Posted Date
2019-08-05
Last Posted Date
2022-09-14
Lead Sponsor
Innovent Biologics (Suzhou) Co. Ltd.
Target Recruit Count
240
Registration Number
NCT04044222
Locations
🇨🇳

Cancer Hospital Chinese Academy of Medical Sciences, Beijing, Beijing, China

Famitinib Plus Camrelizumab & Famitinib Alone & Famitinib Plus Ifosfamide in Advanced Osteosarcoma

First Posted Date
2019-08-05
Last Posted Date
2020-05-19
Lead Sponsor
Peking University People's Hospital
Registration Number
NCT04044378
Locations
🇨🇳

Lu Xie, Beijing, Beijing, China

International Cooperative Treatment Protocol for Children and Adolescents With Lymphoblastic Lymphoma

First Posted Date
2019-08-02
Last Posted Date
2024-07-10
Lead Sponsor
University Hospital Muenster
Target Recruit Count
683
Registration Number
NCT04043494
Locations
🇳🇱

Princess Maxima Centre for Pediatric Oncology, Utrecht, Netherlands

🇫🇷

Unité d'hématologie pédiatrique CHRU de Lille - Hôpital Jeanne de Flandre, Lille, France

🇧🇪

UZ Antwerpen Kinderhemato-oncologie, Edegem, Belgium

and more 219 locations

Acalabrutinib Plus RICE for Relapsed/Refractory DLBCL

First Posted Date
2018-11-09
Last Posted Date
2022-07-22
Lead Sponsor
Swedish Medical Center
Target Recruit Count
47
Registration Number
NCT03736616
Locations
🇺🇸

Swedish Cancer Institute, Seattle, Washington, United States

Chemoimmunotherapy and Allogeneic Stem Cell Transplant for NK T-cell Leukemia/Lymphoma

First Posted Date
2018-10-25
Last Posted Date
2023-10-26
Lead Sponsor
New York Medical College
Target Recruit Count
40
Registration Number
NCT03719105
Locations
🇺🇸

Children's Hospital Orange County, Orange, California, United States

🇺🇸

Helen De Vos, Grand Rapids, Michigan, United States

🇺🇸

University of Alabama, Birmingham, Alabama, United States

and more 3 locations

Combination Chemotherapy With Pazopanib in Children and Adolescents With Relapsed/Refractory Solid Tumors

First Posted Date
2018-08-14
Last Posted Date
2018-09-19
Lead Sponsor
Samsung Medical Center
Target Recruit Count
46
Registration Number
NCT03628131
Locations
🇰🇷

Samsung Medical Center, Seoul, Korea, Republic of

Ascorbic Acid and Chemotherapy for the Treatment of Relapsed or Refractory Lymphoma, CCUS, and Chronic Myelomonocytic Leukemia

First Posted Date
2018-02-01
Last Posted Date
2024-08-05
Lead Sponsor
Mayo Clinic
Target Recruit Count
80
Registration Number
NCT03418038
Locations
🇺🇸

Mayo Clinic Health System-Eau Claire Clinic, Eau Claire, Wisconsin, United States

🇺🇸

Mayo Clinic Health Systems-Mankato, Mankato, Minnesota, United States

🇺🇸

Mayo Clinic Health System-Franciscan Healthcare, La Crosse, Wisconsin, United States

and more 1 locations

Lenalidomide Plus ICE in the Treatment of Refractory and Relapsed DLBCL

First Posted Date
2017-12-08
Last Posted Date
2020-03-11
Lead Sponsor
Ruijin Hospital
Target Recruit Count
39
Registration Number
NCT03367143
Locations
🇨🇳

Shanghai Ruijin Hospital, Shanghai, Shanghai, China

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