Glutathione

Generic Name: Glutathione

Brand Names: -

Drug Type: Small Molecule

Chemical Formula: C_₁₀H_₁₇N_₃O_₆S

CAS Number: 70-18-8

Unique Ingredient Identifier: GAN16C9B8O

Background: A tripeptide with many roles in cells. It conjugates to drugs to make them more soluble for excretion, is a cofactor for some enzymes, is involved in protein disulfide bond rearrangement and reduces peroxides.

Indication: For nutritional supplementation, also for treating dietary shortage or imbalance

Associated Conditions: Hangover, Nerve Disorders, Neuropathy

Associated Therapies: -

Clinical Trials

A Study of Glutathione in Children With Autism Spectrum Disorder

Phase 4

Terminated

Conditions: Autism Spectrum Disorder

Interventions: Drug: Glutathione

First Posted Date: 2023-07-20

Last Posted Date: 2023-08-23

Lead Sponsor: University of Chicago

Target Recruit Count: 6

Registration Number: NCT05954052

Locations: 🇺🇸
The University of Chicago Medicine, Chicago, Illinois, United States

Oral Glutathione As A Skin Whitening Agent

Phase 1

Completed

Conditions: Glutathione
Skin Whitening

Interventions: Drug: Placebo oral tablet
Drug: Glutathione

First Posted Date: 2019-09-26

Last Posted Date: 2019-09-26

Lead Sponsor: Dr Irma Bernadette S Sitohang

Target Recruit Count: 90

Registration Number: NCT04105504

Locations: 🇮🇩
Faculty of Medicine, Universitas Indonesia, Jakarta Pusat, Indonesia

Glutathione vs. Curcumin Clinical Trial

Phase 1

Conditions: Gulf War Syndrome

Interventions: Other: Placebo
Drug: Glutathione
Drug: Curcumin

First Posted Date: 2016-07-28

Last Posted Date: 2020-01-29

Lead Sponsor: South Florida Veterans Affairs Foundation for Research and Education

Target Recruit Count: 75

Registration Number: NCT02848417

Locations: 🇺🇸
Miami VA Center, Miami, Florida, United States

Dual Hypothermic Oxygenated Perfusion of DCD Liver Grafts in Preventing Biliary Complications After Transplantation

Phase 3

Completed

Conditions: Liver Failure
Biliary Tract Diseases
End Stage Liver Disease

Interventions: Procedure: Dual hypothermic oxygenated perfusion
Device: Liver Assist®
Procedure: Perfusion fluid
Drug: Glutathione

First Posted Date: 2015-10-22

Last Posted Date: 2021-01-12

Lead Sponsor: Robert J. Porte

Target Recruit Count: 157

Registration Number: NCT02584283

Locations: 🇧🇪
Ghent University Hospital, Gent, De Pintelaan 185, Belgium
🇳🇱
Leiden Universtiy Medical Center, Leiden, Zuid-Holland, Netherlands
🇧🇪
University Hospitals Leuven, Leuven, Herestraat 49, Belgium

and more 3 locations

CNS Uptake of Intranasal Glutathione

Phase 1

Completed

Conditions: Parkinson's Disease

Interventions: Drug: Reduced Glutathione

First Posted Date: 2014-12-24

Last Posted Date: 2015-04-30

Lead Sponsor: University of Washington

Target Recruit Count: 15

Registration Number: NCT02324426

Locations: 🇺🇸
University of Washington, Seattle, Washington, United States

Glutathione in Preventing Peripheral Neuropathy Caused by Paclitaxel and Carboplatin in Patients With Ovarian Cancer, Fallopian Tube Cancer, and/or Primary Peritoneal Cancer

Phase 3

Completed

Conditions: Chemotherapeutic Agent Toxicity
Neuropathy
Neurotoxicity Syndrome
Pain
Stage IIIA Fallopian Tube Cancer
Stage IIIA Ovarian Cancer
Stage IIIA Primary Peritoneal Cancer
Stage IIIB Fallopian Tube Cancer
Stage IIIB Primary Peritoneal Cancer
Stage IIIB Ovarian Cancer

Interventions: Drug: Carboplatin
Drug: Glutathione
Other: Laboratory Biomarker Analysis
Other: Placebo
Drug: Paclitaxel
Other: Quality-of-Life Assessment

First Posted Date: 2014-12-09

Last Posted Date: 2017-02-23

Lead Sponsor: Alliance for Clinical Trials in Oncology

Target Recruit Count: 195

Registration Number: NCT02311907

Locations: 🇺🇸
Northside Hospital, Atlanta, Georgia, United States
🇺🇸
Saint Joseph's Hospital of Atlanta, Atlanta, Georgia, United States
🇺🇸
Pennsylvania Hospital, Philadelphia, Pennsylvania, United States

and more 385 locations

Combined Drug Approach to Prevent Ischemia-reperfusion Injury During Transplantation of Livers (CAPITL)

Phase 2

Completed

Conditions: Reperfusion Injury

Interventions: Drug: Antithrombin-III
Drug: Sodium chloride solution
Drug: Infliximab
Drug: Apotransferrin
Drug: Human recombinant erythropoietin
Drug: C1-Inhibitor
Drug: Glutathione
Drug: Alfa-tocopherol
Drug: Melatonin
Drug: Epoprostenol

First Posted Date: 2014-09-26

Last Posted Date: 2024-08-23

Lead Sponsor: Universitaire Ziekenhuizen KU Leuven

Target Recruit Count: 143

Registration Number: NCT02251041

Locations: 🇧🇪
University Hospitals Leuven, Leuven, Belgium

Glutathione (GSH) In The Treatment of Parkinson's Disease

Phase 2

Completed

Conditions: Parkinson's Disease

First Posted Date: 2010-08-09

Last Posted Date: 2010-08-09

Lead Sponsor: University of South Florida

Target Recruit Count: 20

Registration Number: NCT01177319

Locations: 🇺🇸
USF Parkinson's Disease and Movement Disorders Center, Tampa, Florida, United States

Polymorphism of Oxidative Stress Genes in the Pathogenesis and Antioxidant Prevention of Contrast Induced Nephropathy

Not Applicable

Completed

Conditions: Nephropathy
Oxidative Stress

Interventions: Drug: saline
Drug: Glutathione

First Posted Date: 2010-06-11

Last Posted Date: 2011-06-27

Lead Sponsor: Huashan Hospital

Target Recruit Count: 1000

Registration Number: NCT01142024

Locations: 🇨🇳
Department of cardiology and nephrology,Huashan Hospital, Shanghai, Shanghai, China

Role of Oral Glutathione in Skin Whitening

Phase 1

Completed

Conditions: Skin Whitening

Interventions: Drug: glutathione
Drug: placebo

First Posted Date: 2009-11-18

Last Posted Date: 2009-11-18

Lead Sponsor: Chulalongkorn University

Target Recruit Count: 60

Registration Number: NCT01016080

Locations: 🇹🇭
King Chulalongkorn Memorial Hospital, Bangkok, Thailand

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