MedPath

Glutathione

Generic Name
Glutathione
Drug Type
Small Molecule
Chemical Formula
C10H17N3O6S
CAS Number
70-18-8
Unique Ingredient Identifier
GAN16C9B8O
Background

A tripeptide with many roles in cells. It conjugates to drugs to make them more soluble for excretion, is a cofactor for some enzymes, is involved in protein disulfide bond rearrangement and reduces peroxides.

Indication

For nutritional supplementation, also for treating dietary shortage or imbalance

Associated Conditions
Hangover, Nerve Disorders, Neuropathy

Combined Drug Approach to Prevent Ischemia-reperfusion Injury During Transplantation of Livers (CAPITL)

Phase 2
Completed
Conditions
Reperfusion Injury
Interventions
First Posted Date
2014-09-26
Last Posted Date
2024-08-23
Lead Sponsor
Universitaire Ziekenhuizen KU Leuven
Target Recruit Count
143
Registration Number
NCT02251041
Locations
🇧🇪

University Hospitals Leuven, Leuven, Belgium

Inhaled Glutathione (GSH) Versus Placebo in Cystic Fibrosis

Phase 3
Conditions
Cystic Fibrosis
Interventions
Drug: Physiological solution
First Posted Date
2011-10-12
Last Posted Date
2011-10-13
Lead Sponsor
Serafino A. Marsico
Target Recruit Count
150
Registration Number
NCT01450267
Locations
🇮🇹

Ospedale Monaldi, Azienda Ospedaliera Universitaria Federico II, Naples, Italy

Intranasal Glutathione in Parkinson's Disease

Phase 1
Completed
Conditions
Parkinson's Disease (PD)
Interventions
Drug: Saline Intranasal Delivery
First Posted Date
2011-07-21
Last Posted Date
2017-07-31
Lead Sponsor
Bastyr University
Target Recruit Count
34
Registration Number
NCT01398748
Locations
🇺🇸

Bastyr Clinical Research Center, Kenmore, Washington, United States

Glutathione (GSH) In The Treatment of Parkinson's Disease

Phase 2
Completed
Conditions
Parkinson's Disease
First Posted Date
2010-08-09
Last Posted Date
2010-08-09
Lead Sponsor
University of South Florida
Target Recruit Count
20
Registration Number
NCT01177319
Locations
🇺🇸

USF Parkinson's Disease and Movement Disorders Center, Tampa, Florida, United States

Polymorphism of Oxidative Stress Genes in the Pathogenesis and Antioxidant Prevention of Contrast Induced Nephropathy

Not Applicable
Completed
Conditions
Nephropathy
Oxidative Stress
Interventions
Drug: saline
First Posted Date
2010-06-11
Last Posted Date
2011-06-27
Lead Sponsor
Huashan Hospital
Target Recruit Count
1000
Registration Number
NCT01142024
Locations
🇨🇳

Department of cardiology and nephrology,Huashan Hospital, Shanghai, Shanghai, China

Oral Glutathione Supplementation on the Levels of Blood Glutathione

Not Applicable
Completed
Conditions
Healthy Adults
Interventions
Drug: Gluthathione peroxidases
Other: Placebo
First Posted Date
2010-01-07
Last Posted Date
2022-09-06
Lead Sponsor
Milton S. Hershey Medical Center
Target Recruit Count
61
Registration Number
NCT01044277
Locations
🇺🇸

Penn State Milton S. Hershey Medical Center, Hershey, Pennsylvania, United States

Role of Oral Glutathione in Skin Whitening

Phase 1
Completed
Conditions
Skin Whitening
Interventions
Drug: placebo
First Posted Date
2009-11-18
Last Posted Date
2009-11-18
Lead Sponsor
Chulalongkorn University
Target Recruit Count
60
Registration Number
NCT01016080
Locations
🇹🇭

King Chulalongkorn Memorial Hospital, Bangkok, Thailand

Study of Glutathione, Vitamin C and Cysteine in Children With Autism and Severe Behavior Problems

Not Applicable
Completed
Conditions
Severe Behavior Disorder
Autism
Interventions
Drug: placebo
Drug: glutathione, vit C and NAC
First Posted Date
2009-04-29
Last Posted Date
2016-12-07
Lead Sponsor
University of Louisville
Target Recruit Count
24
Registration Number
NCT00889538
Locations
🇺🇸

KCPCRU, Louisville, Kentucky, United States

Weekly Dosing of an Integrative Chemotherapy Combination to Treat Advanced Pancreatic Cancer

Phase 2
Conditions
Stage III Pancreatic Cancer
Adenocarincoma of Pancreas
Stage IVB Pancreatic Cancer
Stage IVA Pancreatic Cancer
First Posted Date
2006-05-09
Last Posted Date
2007-05-08
Lead Sponsor
Seattle Cancer Treatment and Wellness Center
Target Recruit Count
80
Registration Number
NCT00323583
Locations
🇺🇸

Seattle Cancer Treatment and Wellness Center, Seattle, Washington, United States

RayGel-An Alternative for Skin Care During External Beam Radiation

Phase 2
Completed
Conditions
Breast Cancer
Interventions
First Posted Date
2005-12-16
Last Posted Date
2013-08-28
Lead Sponsor
Nathalie Johnson
Target Recruit Count
150
Registration Number
NCT00266331
Locations
🇺🇸

Legacy Health System, Portland, Oregon, United States

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