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Ketorolac

Generic Name
Ketorolac
Brand Names
Acular, Acuvail, Omidria, Readysharp Anesthetics Plus Ketorolac, Sprix, Toradol, Toronova Suik
Drug Type
Small Molecule
Chemical Formula
C15H13NO3
CAS Number
74103-06-3
Unique Ingredient Identifier
YZI5105V0L
Background

Ketorolac is a Non-steroidal anti-inflammatory drug (NSAID) and is commercially available as an oral tablet, injectable, nasal spray and as an ophthalmic solution.

It's analgesic properties make it a useful pain management tool across many settings including postoperative pain, rheumatoid arthritis, osteoarthritis, menstrual disorders, headaches, spinal and soft tissue pain, and ankylosing spondylitis. Impressively, ketorolac has a similar efficacy to standard doses of morphine and meperidine making it a useful opioid sparing agent.

Indication

Ketorolac is a Non-steroidal anti-inflammatory drug (NSAID) and has antipyretic, analgesic and anti-inflammatory properties. It is indicated for short term management of acute pain that requires the calibre of pain management offered by opioids. Clinicians may choose to initiate ketorolac to manage post-operative pain, spinal and soft tissue pain, rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, menstrual disorders and headaches among other ailments. Regardless of the etiology of pain, patients should use the lowest possible dose, and avoid using ketorolac for an extended period of time (ideally ≤ 5 days). A benefit of choosing ketorolac over other analgesics with similar potency is that that there does not appear to be a risk of dependence or tolerance with ketorolac use.

Associated Conditions
Acute Migraine, Eye Pain, Inflammation, Macular Edema, Cystoid, Ocular Itching, Pericarditis Acute, Pseudophakic Cystoid Macular Oedema, Severe Acute Pain, Acute, moderate Pain, Chronic aphakic cystoid macular edema, Intraoperative miosis, Postoperative ocular pain
Associated Therapies
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Multimodal Pain Management After Robotic-Assisted Total Laparoscopic Hysterectomy

Phase 3
Completed
Conditions
Pain, Postoperative
Interventions
Drug: Gabapentin
Drug: Hydromorphone
Drug: Acetaminophen
Drug: Celecoxib
Drug: Ketorolac
Procedure: Paracervical block with ropivacaine
Procedure: Local anesthetic injection with ropivacaine at abdominal laparoscopic port sites
Drug: Oxycodone
First Posted Date
2020-06-11
Last Posted Date
2023-08-01
Lead Sponsor
State University of New York at Buffalo
Target Recruit Count
68
Registration Number
NCT04429022
Locations
🇺🇸

Millard Fillmore Suburban Hospital, Williamsville, New York, United States

Effects of Pre-emptive Scalp Infiltration With Low-dose Ketorolac and Ropivacaine for Postoperative Pain

Phase 4
Conditions
Pain
Supratentorial Brain Tumor
Interventions
First Posted Date
2020-05-08
Last Posted Date
2020-09-09
Lead Sponsor
Beijing Tiantan Hospital
Target Recruit Count
40
Registration Number
NCT04380298

Intra-arterial Sphenopalatine Ganglion Block for Patients With Refractory Headache

Phase 1
Withdrawn
Conditions
Chronic Migraine
Cluster Headache
Trigeminal Neuralgia
Interventions
First Posted Date
2020-04-20
Last Posted Date
2020-08-04
Lead Sponsor
Weill Medical College of Cornell University
Registration Number
NCT04353505
Locations
🇺🇸

Weill Cornell Medicine, New York, New York, United States

Initial Pain Management in Pediatric Pancreatitis: Opioid vs. Non-Opioid

Phase 2
Recruiting
Conditions
Acute Pancreatitis
Interventions
Drug: Opioid
Drug: Ketorolac
First Posted Date
2020-03-02
Last Posted Date
2024-02-14
Lead Sponsor
Boston Children's Hospital
Target Recruit Count
50
Registration Number
NCT04291599
Locations
🇺🇸

Boston Children's Hospital, Boston, Massachusetts, United States

Ketorolac in Acute Pancreatitis

Phase 4
Conditions
Acute Pancreatitis
Interventions
First Posted Date
2020-02-24
Last Posted Date
2020-12-08
Lead Sponsor
University of Cincinnati
Target Recruit Count
60
Registration Number
NCT04282200
Locations
🇺🇸

University of Cincinnati Medical Center, Cincinnati, Ohio, United States

Multimodal Pain Study in Free Flap Patients

Phase 4
Completed
Conditions
Analgesia
Head and Neck Cancer
Interventions
First Posted Date
2020-01-29
Last Posted Date
2023-08-18
Lead Sponsor
University of Kansas Medical Center
Target Recruit Count
30
Registration Number
NCT04246697
Locations
🇺🇸

University of Kansas Medical Center, Kansas City, Kansas, United States

Ketorolac as an Adjuvant Agent for Postoperative Pain Control Following Arthroscopic ACL Surgery

Phase 3
Completed
Conditions
ACL Injury
Postoperative Pain
Interventions
Drug: Oxycodone-Acetaminophen
Drug: Ketorolac
First Posted Date
2020-01-29
Last Posted Date
2021-12-21
Lead Sponsor
University Hospitals Cleveland Medical Center
Target Recruit Count
49
Registration Number
NCT04246554
Locations
🇺🇸

UH Cleveland Medical Center, Cleveland, Ohio, United States

Ketorolac as an Adjuvant Agent for Postoperative Pain Control Following Arthroscopic Meniscus Surgery

Phase 3
Completed
Conditions
Opioid Use
Postoperative Complications
Pain, Postoperative
Ketorolac Adverse Reaction
Meniscus Tear, Tibial
Interventions
Drug: Oxycodone-Acetaminophen
Drug: Ketorolac
First Posted Date
2020-01-29
Last Posted Date
2022-03-03
Lead Sponsor
University Hospitals Cleveland Medical Center
Target Recruit Count
48
Registration Number
NCT04246541
Locations
🇺🇸

UH Cleveland Medical Center, Cleveland, Ohio, United States

Effects of Pre-emptive Scalp Infiltration With Ketorolac and Ropivacaine for Post-craniotomy Pain

Phase 4
Conditions
Pain
Supratentorial Brain Tumor
Interventions
First Posted Date
2019-10-28
Last Posted Date
2020-01-22
Lead Sponsor
Beijing Tiantan Hospital
Target Recruit Count
100
Registration Number
NCT04141319

Ibuprofen Versus Ketorolac by Mouth in the Treatment of Acute Pain From Osteoarticular Trauma

Phase 3
Completed
Conditions
Acute Pain Due to Trauma
Interventions
First Posted Date
2019-10-21
Last Posted Date
2022-01-06
Lead Sponsor
IRCCS Burlo Garofolo
Target Recruit Count
212
Registration Number
NCT04133623
Locations
🇮🇹

Azienda Ospedaliera Santa Maria degli Angeli, Pordenone, Italy

🇮🇹

Institute for Maternal and Child Health - IRCCS Burlo Garofolo-, Trieste, Italy

🇮🇹

Ospedale Santa Maria della Misericordia, Udine, Italy

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