MedPath

Ketorolac

Generic Name
Ketorolac
Brand Names
Acular, Acuvail, Omidria, Readysharp Anesthetics Plus Ketorolac, Sprix, Toradol, Toronova Suik
Drug Type
Small Molecule
Chemical Formula
C15H13NO3
CAS Number
74103-06-3
Unique Ingredient Identifier
YZI5105V0L
Background

Ketorolac is a Non-steroidal anti-inflammatory drug (NSAID) and is commercially available as an oral tablet, injectable, nasal spray and as an ophthalmic solution.

It's analgesic properties make it a useful pain management tool across many settings including postoperative pain, rheumatoid arthritis, osteoarthritis, menstrual disorders, headaches, spinal and soft tissue pain, and ankylosing spondylitis. Impressively, ketorolac has a similar efficacy to standard doses of morphine and meperidine making it a useful opioid sparing agent.

Indication

Ketorolac is a Non-steroidal anti-inflammatory drug (NSAID) and has antipyretic, analgesic and anti-inflammatory properties. It is indicated for short term management of acute pain that requires the calibre of pain management offered by opioids. Clinicians may choose to initiate ketorolac to manage post-operative pain, spinal and soft tissue pain, rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, menstrual disorders and headaches among other ailments. Regardless of the etiology of pain, patients should use the lowest possible dose, and avoid using ketorolac for an extended period of time (ideally ≤ 5 days). A benefit of choosing ketorolac over other analgesics with similar potency is that that there does not appear to be a risk of dependence or tolerance with ketorolac use.

Associated Conditions
Acute Migraine, Eye Pain, Inflammation, Macular Edema, Cystoid, Ocular Itching, Pericarditis Acute, Pseudophakic Cystoid Macular Oedema, Severe Acute Pain, Acute, moderate Pain, Chronic aphakic cystoid macular edema, Intraoperative miosis, Postoperative ocular pain

A Pharmacokinetic Study of Intravenous NTM-001 in Healthy Chinese Subjects

Phase 1
Completed
Conditions
Healthy Volunteers
Interventions
First Posted Date
2022-05-19
Last Posted Date
2023-03-31
Lead Sponsor
Nuance Pharma (shanghai) Co., Ltd
Target Recruit Count
16
Registration Number
NCT05382546
Locations
🇨🇳

HUK Phase 1 clinical trials center, Hong Kong, Hong Kong, China

Ketorolac-an Option for Post Operative Pain Management After Elective Cardiac Surgery.

Phase 4
Completed
Conditions
Coronary Artery Disease
Post Operative Pain
Analgesia
Coronary Artery Bypass Grafting Surgery
Interventions
First Posted Date
2022-05-05
Last Posted Date
2022-09-30
Lead Sponsor
National Institute of Cardiovascular Diseases, Pakistan
Target Recruit Count
60
Registration Number
NCT05361824
Locations
🇵🇰

National Institute of Cardiovascular Diseases, Karachi, Sindh, Pakistan

A Feasibility Study of Ketorolac Treatment for Cachexia in Patients With Advanced Pancreatic Ductal Adenocarcinoma

Early Phase 1
Active, not recruiting
Conditions
Pancreatic Ductal Adenocarcinoma
Pancreatic Cancer
Pancreas Cancer
Interventions
First Posted Date
2022-04-20
Last Posted Date
2025-03-27
Lead Sponsor
Andrew Hendifar, MD
Target Recruit Count
20
Registration Number
NCT05336266
Locations
🇺🇸

Cedars- Sinai Medical Center, Los Angeles, California, United States

Ketorolac Applied by Continuous IV Infusion for Treatment of Moderately Severe Postoperative Pain Following Bunionectomy

Phase 3
Recruiting
Conditions
Pain, Postoperative
Interventions
Other: Intravenous Placebo for NTM-001
Other: IV Placebo for Morphine
First Posted Date
2022-04-12
Last Posted Date
2024-03-21
Lead Sponsor
NEMA Research, Inc.
Target Recruit Count
360
Registration Number
NCT05324358
Locations
🇺🇸

The Orthopedic Center, Tulsa, Oklahoma, United States

🇺🇸

Sun City Clinical Research, Sun City, Arizona, United States

🇺🇸

Trovare Clinical Research, Bakersfield, California, United States

and more 7 locations

Ketorolac in Upper Extremity Tendinopathy and Arthropathy

First Posted Date
2022-03-23
Last Posted Date
2025-04-03
Lead Sponsor
Emory University
Target Recruit Count
160
Registration Number
NCT05292339
Locations
🇺🇸

Emory Saint Joseph's Hospital, Atlanta, Georgia, United States

🇺🇸

Emory University Orthopaedic and Spine Center, Atlanta, Georgia, United States

🇺🇸

12 Executive Park Drive, Atlanta, Georgia, United States

and more 1 locations

Meloxicam for Pain Management After Total Joint Arthroplasty (TJA)

Phase 3
Completed
Conditions
Total Hip Replacement
Total Knee Replacement
Interventions
First Posted Date
2022-03-22
Last Posted Date
2024-08-14
Lead Sponsor
University of Miami
Target Recruit Count
223
Registration Number
NCT05291598
Locations
🇺🇸

University of Miami, Miami, Florida, United States

Dosing of Ketorolac Impacts Post-cesarean paiN manaGemenet (KING)

Completed
Conditions
Post Cesarean Pain
Interventions
First Posted Date
2022-02-21
Last Posted Date
2024-01-05
Lead Sponsor
Ohio State University
Target Recruit Count
92
Registration Number
NCT05248984
Locations
🇺🇸

The Ohio State University Wexner Medical Center OB/GYN Maternal and Fetal Medicine, Columbus, Ohio, United States

Ibuprofen Versus Ketorolac for Pain Relief During Hysterosalpingogram

Phase 4
Terminated
Conditions
Infertility, Female
Interventions
First Posted Date
2022-01-13
Last Posted Date
2024-12-24
Lead Sponsor
Madigan Army Medical Center
Target Recruit Count
12
Registration Number
NCT05190341
Locations
🇺🇸

Madigan Army Medical Center, Tacoma, Washington, United States

Analgesia for Thyroidectomy Using Bilateral Superficial Cervical Plexus Block With Bupivacaine Only or Adding Ketorolac to it.

Phase 2
Completed
Conditions
Thyroid Nodule
Thyroid Goiter
Interventions
First Posted Date
2022-01-06
Last Posted Date
2022-01-21
Lead Sponsor
Sohag University
Target Recruit Count
46
Registration Number
NCT05180214
Locations
🇪🇬

Sohag University Faculty of Medicine, Sohag, Egypt

Esketamine vs. Ketorolac for Prevention of Postoperative Pain and Cognitive Dysfunction After Total Knee Arthroplasty

Not Applicable
Conditions
Postoperative Pain
Postoperative Cognitive Dysfunction
Total Knee Arthroplasty
Interventions
First Posted Date
2021-11-24
Last Posted Date
2022-04-15
Lead Sponsor
Tianjin Medical University General Hospital
Target Recruit Count
160
Registration Number
NCT05132595
Locations
🇨🇳

Tianjin Medical University General Hospital, Tianjin, China

© Copyright 2025. All Rights Reserved by MedPath