Isotretinoin
- Generic Name
- Isotretinoin
- Brand Names
- Absorica, Accutane, Amnesteem, Claravis, Clarus, Epuris, Myorisan, Sotret, Zenatane
- Drug Type
- Small Molecule
- Chemical Formula
- C20H28O2
- CAS Number
- 4759-48-2
- Unique Ingredient Identifier
- EH28UP18IF
- Background
Isotretinoin is a retinoid derivative of vitamin A used in the treatment of severe recalcitrant acne. It was most widely marketed under the brand name Accutane, which has since been discontinued. Isotretinoin is associated with major risks in pregnancy and is therefore only available under the iPLEDGE program in the United States. The first isotretinoin-cont...
- Indication
Isotretinoin is indicated to treat severe recalcitrant nodular acne and patients ≥12 years enrolled in the iPLEDGE program.
- Associated Conditions
- Acne conglobata, Neuroblastoma (NB), Rosacea, Sezary Syndrome, Early Mycosis Fungoides (MF), Refractory Acne vulgaris, Severe Recalcitrant nodular acne
- Associated Therapies
- -
13-cis Retinoic Acid (Isotretinoin) and Sperm Production
- Conditions
- Interventions
- First Posted Date
- 2024-11-20
- Last Posted Date
- 2024-11-25
- Lead Sponsor
- University Hospital, Strasbourg, France
- Target Recruit Count
- 100
- Registration Number
- NCT06698263
- Locations
- 🇫🇷
CECOS Alsace Strasbourg, Schiltigheim, France
Weekly Isotretinoin Vs Tetracycline for Moderate Acne
- Conditions
- Interventions
- First Posted Date
- 2024-01-26
- Last Posted Date
- 2024-10-30
- Lead Sponsor
- Medical University of South Carolina
- Target Recruit Count
- 50
- Registration Number
- NCT06225570
Oral Isotretinoin in Melasma a Randomized Controlled Trial
- First Posted Date
- 2024-01-11
- Last Posted Date
- 2024-01-11
- Lead Sponsor
- Zagazig University
- Target Recruit Count
- 40
- Registration Number
- NCT06201624
- Locations
- 🇪🇬
Dermatology department, Zagazig University Hospitals, Faculty of Medicine, Zagazig University, Zagazig, Select Region, Egypt
Dinutuximab With Chemotherapy, Surgery and Stem Cell Transplantation for the Treatment of Children With Newly Diagnosed High Risk Neuroblastoma
- Conditions
- Interventions
- Procedure: Biospecimen CollectionProcedure: Bone Marrow AspirationProcedure: Bone Marrow BiopsyDrug: CarboplatinDrug: CisplatinProcedure: Computed TomographyDrug: CyclophosphamideBiological: DinutuximabDrug: DoxorubicinDrug: EtoposideProcedure: FDG-Positron Emission Tomography and Computed Tomography ScanProcedure: Hematopoietic Cell TransplantationDrug: IrinotecanDrug: IsotretinoinProcedure: LeukapheresisProcedure: Magnetic Resonance ImagingDrug: MelphalanRadiation: Radiation TherapyProcedure: Radionuclide ImagingOther: Survey AdministrationDrug: TemozolomideDrug: ThiotepaDrug: TopotecanProcedure: Tumor ResectionDrug: Vincristine
- First Posted Date
- 2023-12-15
- Last Posted Date
- 2024-12-18
- Lead Sponsor
- National Cancer Institute (NCI)
- Target Recruit Count
- 478
- Registration Number
- NCT06172296
- Locations
- 🇺🇸
Blank Children's Hospital, Des Moines, Iowa, United States
🇺🇸Vanderbilt University/Ingram Cancer Center, Nashville, Tennessee, United States
🇺🇸Children's Hospital of Alabama, Birmingham, Alabama, United States
The Effects of Systemic Isotretinoin Treatment on Adrenal Steroid and Sex Hormones Level in Severe Acne Vulgaris
- First Posted Date
- 2023-06-15
- Last Posted Date
- 2023-06-15
- Lead Sponsor
- Marmara University
- Target Recruit Count
- 40
- Registration Number
- NCT05903716
- Locations
- 🇹🇷
Marmara University School of Medicine,Department of Dermatology., Istanbul, Turkey
Effect of Systemic Isotretinoin on Serum Irisin Level in Acne Vulgaris Patients
- First Posted Date
- 2023-05-22
- Last Posted Date
- 2024-12-09
- Lead Sponsor
- South Valley University
- Target Recruit Count
- 60
- Registration Number
- NCT05869188
- Locations
- 🇪🇬
Qena Hospital, Qinā, Egypt
Serum TWEAK Levels in Acne Vulgaris
- Conditions
- Interventions
- First Posted Date
- 2023-01-13
- Last Posted Date
- 2023-01-13
- Lead Sponsor
- South Valley University
- Target Recruit Count
- 150
- Registration Number
- NCT05684861
- Locations
- 🇪🇬
South Valley University, Qinā, Qena, Egypt
Measure the Serum Level of Homocysteine in Acne Patients Before and After Oral Isotretinoin.
- First Posted Date
- 2022-09-07
- Last Posted Date
- 2022-09-07
- Lead Sponsor
- Aswan University
- Target Recruit Count
- 60
- Registration Number
- NCT05529888
- Locations
- 🇪🇬
Aswan University-Faculty of Medicine, Aswan, New Aswan City, Egypt
Investigation of the Effect of Oral Isotretinoin on Skin Thickness and Elasticity in Patients With Atrophic Acne Scar
- First Posted Date
- 2022-06-09
- Last Posted Date
- 2022-06-09
- Lead Sponsor
- Istanbul Training and Research Hospital
- Target Recruit Count
- 30
- Registration Number
- NCT05413200
- Locations
- 🇹🇷
Istanbul Training and Research Hospital, Istanbul, Turkey
Evaluation of the Safety and Pharmacokinetics of Dinutuximab Beta As Maintenance Therapy in Chinese Participants With High-Risk Neuroblastoma
- Conditions
- Interventions
- First Posted Date
- 2022-05-13
- Last Posted Date
- 2024-10-04
- Lead Sponsor
- BeiGene
- Target Recruit Count
- 8
- Registration Number
- NCT05373901
- Locations
- 🇨🇳
Xinhua Hospital Affiliated To Shanghai Jiao Tong University School Of Medicine, Shanghai, Shanghai, China
🇨🇳Tianjin Medical University Cancer Institute & Hospital, Tianjin, Tianjin, China
🇨🇳The Children's Hospital Zhejiang University School of Medicine, Hangzhou, Zhejiang, China
Drug Development Updates
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