Efavirenz

Generic Name: Efavirenz

Brand Names: Atripla, Stocrin, Sustiva, Symfi, Efavirenz Teva

Drug Type: Small Molecule

Chemical Formula: C_₁₄H_₉ClF_₃NO_₂

CAS Number: 154598-52-4

Unique Ingredient Identifier: JE6H2O27P8

Background: Efavirenz (brand names Sustiva® and Stocrin®) is a non-nucleoside reverse transcriptase inhibitor (NNRTI) and is used as part of highly active antiretroviral therapy (HAART) for the treatment of a human immunodeficiency virus (HIV) type 1.

For HIV infection that has not previously been treated, efavirenz and lamivudine in combination with zidovudine or tenofovir is the preferred NNRTI-based regimen.

Efavirenz is also used in combination with other antiretroviral agents as part of an expanded postexposure prophylaxis regimen to prevent HIV transmission for those exposed to materials associated with a high risk for HIV transmission.

Indication: For use in combination treatment of HIV infection (AIDS)

Associated Conditions: Human Immunodeficiency Virus Type 1 (HIV-1) Infection

Clinical Trials

Efficacy and Safety of a Dolutegravir-based Regimen for the Initial Management of HIV Infected Adults in Resource-limited Settings

Phase 3

Completed

Conditions: HIV-1 Infection

Interventions: Drug: Dolutegravir 50 mg
Drug: Efavirenz 400 mg
Drug: Tenofovir disoproxil fumarate 300 mg / lamivudine 300 mg

First Posted Date: 2016-05-19

Last Posted Date: 2021-08-31

Lead Sponsor: ANRS, Emerging Infectious Diseases

Target Recruit Count: 616

Registration Number: NCT02777229

Locations: 🇨🇲
Military Hospital, Yaoundé, Cameroon
🇨🇲
Hopital Central, Yaoundé, Cameroon
🇨🇲
Cité verte Hospital, Yaoundé, Cameroon

Pharmacologic Strategies to Use the Levonorgestrel Implant in HIV-infected Women

Phase 2

Completed

Conditions: HIV
Contraception

Interventions: Drug: Levonorgestrel
Drug: Efavirenz

First Posted Date: 2016-03-30

Last Posted Date: 2024-10-03

Lead Sponsor: University of Nebraska

Target Recruit Count: 28

Registration Number: NCT02722421

Locations: 🇺🇬
Infectious Diseases Institute, Kampala, Uganda

Interaction With HIV Antiretroviral Agents

Phase 1

Completed

Conditions: HIV-DDI

Interventions: Drug: Riociguat (Adempas, BAY 63-2521)
Drug: TRIUMEQ
Drug: STRIBILD
Drug: Antiretroviral protease inhibitor
Drug: ATRIPLA
Drug: COMPLERA

First Posted Date: 2015-09-22

Last Posted Date: 2017-12-06

Lead Sponsor: Bayer

Target Recruit Count: 40

Registration Number: NCT02556268

Evolution of Plasma Lipid Profile in Patients With HIV1 Who Change Atripla to Eviplera Compared to Continue With Atripla

Phase 4

Completed

Conditions: HIV-1

Interventions: Drug: efavirenz + emtricitabina + tenofovir
Drug: rilpivirina + emtricitabina + tenofovir

First Posted Date: 2015-09-11

Last Posted Date: 2017-06-14

Lead Sponsor: Hospital Universitari Vall d'Hebron Research Institute

Target Recruit Count: 30

Registration Number: NCT02547844

Locations: 🇪🇸
Hospital Universitari Vall d'Hebron, Barcelona, Spain

SSAT063- Pharmacokinetics of Efavirenz 400 mg Once Daily During Pregnancy in HIV-1 Infected Women

Phase 1

Completed

Conditions: HIV

Interventions: Drug: Efavirenz
Drug: tenofovir /emtricitabine
Drug: tenofovir/lamivudine
Drug: lamivudine/zidovudine

First Posted Date: 2015-07-16

Last Posted Date: 2017-10-20

Lead Sponsor: St Stephens Aids Trust

Target Recruit Count: 26

Registration Number: NCT02499874

Locations: 🇬🇧
St Stephen's Centre, Chelsea and Westminster Hospital, London, United Kingdom

Efficacy, Safety and Optimal Dose of VM-1500 in Comparison to Efavirenz Added to Standard-of-care Antiretroviral Therapy

Phase 2

Completed

Conditions: HIV-1-infection

Interventions: Drug: VM-1500
Drug: Efavirenz
Drug: Antiretroviral therapy (ART)

First Posted Date: 2015-07-03

Last Posted Date: 2018-09-25

Lead Sponsor: Viriom

Target Recruit Count: 150

Registration Number: NCT02489461

Locations: 🇷🇺
Moscow Prevention AIDS Center, Moscow, Russian Federation
🇷🇺
Lipetsk regional center for AIDS prevention, Lipetsk, Lipetsk Region, Russian Federation
🇷🇺
Perm Regional center for AIDS prevention, Perm, Perm Region, Russian Federation

and more 10 locations