Salmeterol

Generic Name: Salmeterol

Brand Names: Advair, Airduo, Airduo Respiclick, Serevent, Serevent Diskus, Wixela

Drug Type: Small Molecule

Chemical Formula: C_₂₅H_₃₇NO_₄

CAS Number: 89365-50-4

Unique Ingredient Identifier: 2I4BC502BT

Background: Salmeterol is a long-acting beta-2 adrenergic receptor agonist drug that is currently prescribed for the treatment of asthma and chronic obstructive pulmonary disease COPD. It has a longer duration of action than the short-acting beta-2 adrenergic receptor agonist, salbutamol. Salmeterol was first described in the literature in 1988. Salmeterol's structure is similar to salbutamol's with an aralkyloxy-alkyl substitution on the amine.

Salmeterol was granted FDA approval on 4 February 1994.

Indication: 用于哮喘（包括夜间哮喘和运动性哮喘）、喘息性支气管炎和可逆性气道阻塞。

Associated Conditions: Asthma, Chronic Obstructive Pulmonary Disease (COPD), Exercise-Induced Bronchospasm

Clinical Trials

Special Drug Use Investigation for ADOAIR Metered-dose Inhaler (Pediatric)

Completed

Conditions: Asthma

Interventions: Drug: Salmeterol and Fluticasone

First Posted Date: 2011-04-11

Last Posted Date: 2014-07-08

Lead Sponsor: GlaxoSmithKline

Target Recruit Count: 300

Registration Number: NCT01332422

A 4-week Dose-Ranging, Dose-Interval, Efficacy, Safety and Tolerability Study of GSK961081 in Subjects With Chronic Obstructive Pulmonary Disease (COPD)

Phase 2

Completed

Conditions: Pulmonary Disease, Chronic Obstructive

Interventions: Drug: GSK961081
Drug: Salmeterol
Drug: Placebo

First Posted Date: 2011-03-21

Last Posted Date: 2016-12-01

Lead Sponsor: GlaxoSmithKline

Target Recruit Count: 437

Registration Number: NCT01319019

Locations: 🇺🇦
GSK Investigational Site, Vinnytsia, Ukraine

Blacks and Exacerbations on Long Acting Beta Agonists (LABA) vs. Tiotropium (BELT)

Phase 3

Completed

Conditions: Asthma

Interventions: Drug: Salmeterol
Drug: Tiotropium
Drug: Formoterol

First Posted Date: 2011-02-07

Last Posted Date: 2018-03-30

Lead Sponsor: Brigham and Women's Hospital

Target Recruit Count: 1070

Registration Number: NCT01290874

Locations: 🇺🇸
G.A. Carmichael F.H.C., Canton, Mississippi, United States
🇺🇸
Edward Waters College Medical Center (Mayo), Jacksonville, Florida, United States
🇺🇸
Northwestern University, Chicago, Illinois, United States

and more 10 locations

Effect of Salmeterol on Fluid Clearance From Alveolar-Capillary Membrane in COPD Patients

Not Applicable

Completed

Conditions: Salmeterol Effect Against an Acute Alveolar Fluid Clearance Challenge Secondary to Lung Fluid Overload in COPD Patients
Chronic Obstructive Pulmonary Disease
Bronchodilator Agents
Salmeterol

Interventions: Drug: Salmeterol
Procedure: saline infusion (0.9 per cent sodium chloride)
Other: Placebo

First Posted Date: 2011-01-06

Last Posted Date: 2011-01-06

Lead Sponsor: University of Milan

Target Recruit Count: 20

Registration Number: NCT01271556

Locations: 🇮🇹
Respiratory Medicine Section, Dipartimento Toraco-Polmonare e Cardiocircolatorio, Università degli Studi di Milano, San Paolo Hospital, Milan, Italy

Effects on Small Airways of Two Long-term Extrafine Treatments in Asthma

Phase 4

Completed

Conditions: Bronchial Asthma

Interventions: Drug: formoterol - beclometasone
Drug: Salmeterol Fluticasone

First Posted Date: 2010-12-07

Last Posted Date: 2010-12-07

Lead Sponsor: Università degli Studi di Brescia

Target Recruit Count: 10

Registration Number: NCT01255579

Interactive Acute Smooth Muscle Effects of Salmeterol and Fluticasone in the Airway

Not Applicable

Completed

Conditions: Asthma

Interventions: Drug: fluticasone/salmeterol
Drug: placebo inhalation
Drug: Salmeterol
Drug: fluticasone

First Posted Date: 2010-11-01

Last Posted Date: 2016-06-30

Lead Sponsor: University of Miami

Target Recruit Count: 14

Registration Number: NCT01231230

Effects of Inhaled Corticosteroids on Sputum Bacterial Load in COPD

Not Applicable

Completed

Conditions: Chronic Obstructive Pulmonary Disease

Interventions: Drug: Salmeterol
Drug: Salmeterol/Fluticasone combination

First Posted Date: 2010-10-04

Last Posted Date: 2016-04-08

Lead Sponsor: Università degli Studi di Ferrara

Target Recruit Count: 60

Registration Number: NCT01213693

Locations: 🇮🇹
Research Centre on Asthma and COPD - Department of Clinical and Experimental Medicine - Section of Respiratory Disease - University of Ferrara, Ferrara, Italy