Rocuronium

Generic Name
Rocuronium
Brand Names
-
Drug Type
Small Molecule
Chemical Formula
C32H53N2O4
CAS Number
143558-00-3
Unique Ingredient Identifier
WRE554RFEZ
Background

Rocuronium (rapid onset-curonium) is a desacetoxy analogue of vecuronium with a more rapid onset of action. It is an aminosteroid non-depolarizing neuromuscular blocker or muscle relaxant used in modern anaesthesia, to facilitate endotracheal intubation and to provide skeletal muscle relaxation during surgery or mechanical ventilation. Introduced in 1994, rocuronium has rapid onset, and intermediate duration of action. It is commonly marketed under the trade names Zemuron and Esmeron. The drug is associated with the risk of developing allergic reactions in some high-risk patients, such as those with asthma. However, there was a similar incidence of allergic reactions associated with other non-depolarizing neuromuscular blocking agents. Sugammadex is a γ-cyclodextrin derivative that has been introduced as a novel agent to reverse the action of rocuronium.

Indication

For inpatients and outpatients as an adjunct to general anesthesia to facilitate both rapid sequence and routine tracheal intubation, and to provide skeletal muscle relaxation during surgery or mechanical ventilation.

Associated Conditions
Muscle fasciculation caused by succinylcholine
Associated Therapies
Curarization therapy, Neuromuscular blocking therapy, Facilitation of small bowel intubation therapy

Can Adequacy of Anesthesia Depth and Quality of Recovery be Influenced by the Level of Neuromuscular Blockade?

Phase 4
Completed
Conditions
Interventions
First Posted Date
2015-06-29
Last Posted Date
2019-09-16
Lead Sponsor
Centro Hospitalar do Porto
Target Recruit Count
70
Registration Number
NCT02484651
Locations
🇵🇹

Centro Hospitalar do Porto, Porto, Portugal

Optimal Inspiratory Pressure for Facemask Pressure-controlled Ventilation in Children

Not Applicable
Completed
Conditions
Interventions
First Posted Date
2015-06-15
Last Posted Date
2019-01-31
Lead Sponsor
Seoul National University Hospital
Target Recruit Count
120
Registration Number
NCT02471521
Locations
🇰🇷

Seoul National University Hospital, Seoul, Korea, Republic of

Respiratory Mechanics and Metabolic Changes During Low Pressure Laparoscopic Cholecystectomy

Phase 2
Completed
Conditions
Interventions
First Posted Date
2015-06-12
Last Posted Date
2017-03-28
Lead Sponsor
Assiut University
Target Recruit Count
40
Registration Number
NCT02469831
Locations
🇪🇬

Al Rajhy liver hospital, Assuit, اسيوط, Egypt

Sugammadex Versus Neostigmine in Patients With Liver Cirrhosis Undergoing Liver Resection

First Posted Date
2015-04-13
Last Posted Date
2016-02-02
Lead Sponsor
Cairo University
Target Recruit Count
60
Registration Number
NCT02414880
Locations
🇪🇬

National Liver institute, Garden City, Cairo, Egypt

The Necessity of Routine Mask Ventilation in Adults

First Posted Date
2015-03-27
Last Posted Date
2017-01-25
Lead Sponsor
Yonsei University
Target Recruit Count
288
Registration Number
NCT02400931
Locations
🇰🇷

Department of Anesthesiology and Pain Medicine, Yonsei University College of Medicine, Seoul, Korea, Republic of

Pharmacokinetic and Pharmacodynamic of Rocuronium

Completed
Conditions
Interventions
First Posted Date
2015-03-03
Last Posted Date
2015-03-03
Lead Sponsor
Pontificia Universidad Catolica de Chile
Target Recruit Count
10
Registration Number
NCT02376595

Deep Neuromuscular Relaxation in Patients for Thoraco-laparoscopic Esophagectomy

First Posted Date
2014-12-19
Last Posted Date
2016-09-19
Lead Sponsor
Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Target Recruit Count
66
Registration Number
NCT02320734
Locations
🇳🇱

Academic Medical Center, Amsterdam, Noord-Holland, Netherlands

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