Ondansetron
- Generic Name
- Ondansetron
- Brand Names
- Zofran, Zuplenz
- Drug Type
- Small Molecule
- Chemical Formula
- C18H19N3O
- CAS Number
- 99614-02-5
- Unique Ingredient Identifier
- 4AF302ESOS
- Background
A competitive serotonin type 3 receptor antagonist. It is effective in the treatment of nausea and vomiting caused by cytotoxic chemotherapy drugs, including cisplatin, and has reported anxiolytic and neuroleptic properties.
...
- Indication
In the adult patient population:
i) orally administered ondansetron tablets and orally disintegrating tablets (ODT) are indicated for:
- the prevention of nausea and vomiting associated with emetogenic cancer chemotherapy, including high dose (ie. greater than or equal to 50 mg/m2) cisplatin therapy, and radiotherapy, and
...
- Associated Conditions
- Chemotherapy-Induced Nausea and Vomiting, Cholestatic pruritus, Post Operative Nausea and Vomiting (PONV), Radiation-Induced Nausea and Vomiting, Uremic Pruritus, Severe Hyperemesis gravidarum
- Associated Therapies
- -
Ultrasound-guided Blocks for Ambulatory Knee Arthroscopy
- First Posted Date
- 2013-04-23
- Last Posted Date
- 2013-11-06
- Lead Sponsor
- Jens Borglum Neimann
- Target Recruit Count
- 60
- Registration Number
- NCT01837394
- Locations
- 🇩🇰
Department of Anesthesiology, Bispebjerg Hospital, Copenhagen, Denmark
Ondansetron for Pediatric Mild Traumatic Brain Injury
- Conditions
- Interventions
- First Posted Date
- 2013-03-20
- Last Posted Date
- 2015-09-29
- Lead Sponsor
- St. Justine's Hospital
- Target Recruit Count
- 16
- Registration Number
- NCT01815125
- Locations
- 🇨🇦
CHU Sainte-Justine, Montreal, Quebec, Canada
Liver Fibrosis in Alpha-1 Antitrypsin Deficiency (Liver AATD)
- Conditions
- Interventions
- First Posted Date
- 2013-03-13
- Last Posted Date
- 2023-08-21
- Lead Sponsor
- University of Florida
- Target Recruit Count
- 109
- Registration Number
- NCT01810458
- Locations
- 🇺🇸
Shands at the University of Florida, Gainesville, Florida, United States
How Pregnant Women and Their Babies Metabolize Ondansetron Compared to a Group of Non-pregnant Women
- First Posted Date
- 2013-02-28
- Last Posted Date
- 2015-06-01
- Lead Sponsor
- Stanford University
- Target Recruit Count
- 100
- Registration Number
- NCT01801475
- Locations
- 🇺🇸
Lucile Packard Children's Hospital & Stanford Hospital, Palo Alto, California, United States
Ondansetron and the QT Interval In Adult Emergency Department Patients
- First Posted Date
- 2013-01-03
- Last Posted Date
- 2014-06-26
- Lead Sponsor
- C.R.Darnall Army Medical Center
- Target Recruit Count
- 28
- Registration Number
- NCT01759420
- Locations
- 🇺🇸
Carl R Darnall Army Medical Center, Fort Hood, Texas, United States
🇺🇸Madigan Army Medical Center, Tacoma, Washington, United States
A Study to Evaluate Aprepitant for the Prevention of Post-Operative Nausea and Vomiting in Children (MK-0869-219)
- Conditions
- Interventions
- First Posted Date
- 2012-11-22
- Last Posted Date
- 2018-09-25
- Lead Sponsor
- Merck Sharp & Dohme LLC
- Target Recruit Count
- 229
- Registration Number
- NCT01732458
Study of the Pharmacokinetics, Pharmacodynamics, Safety and Tolerability of Fosaprepitant for the Prevention of Chemotherapy-Induced Nausea and Vomiting (CINV) in Children (MK-0517-029)
- Conditions
- Interventions
- First Posted Date
- 2012-10-02
- Last Posted Date
- 2019-06-25
- Lead Sponsor
- Merck Sharp & Dohme LLC
- Target Recruit Count
- 240
- Registration Number
- NCT01697579
Analgesic Effect of IV Acetaminophen in Tonsillectomies
- First Posted Date
- 2012-09-25
- Last Posted Date
- 2017-04-06
- Lead Sponsor
- Nationwide Children's Hospital
- Target Recruit Count
- 250
- Registration Number
- NCT01691690
- Locations
- 🇺🇸
Nationwide Children's Hospital, Columbus, Ohio, United States
Antagonism Research Between Antiemetics Agents and Acetaminophen in Thyroidectomy's Post-operative Analgesia.
- Conditions
- Interventions
- First Posted Date
- 2012-09-05
- Last Posted Date
- 2016-10-27
- Lead Sponsor
- University Hospital, Lille
- Target Recruit Count
- 66
- Registration Number
- NCT01679093
- Locations
- 🇫🇷
Hôpital Claude Huriez, CHRU, Lille, France
Effects of Different Kinds, Different Doses of 5-HT3 Receptor Antagonists on Prevention of Hypotension
- Conditions
- Interventions
- First Posted Date
- 2012-08-20
- Last Posted Date
- 2012-08-20
- Lead Sponsor
- Seoul National University Hospital
- Target Recruit Count
- 100
- Registration Number
- NCT01669213
- Locations
- 🇰🇷
Seoul National University Hospital, Seoul, Korea, Republic of
Drug Development Updates
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