Estradiol
- Generic Name
- Estradiol
- Brand Names
- Activella 1/0.5 28 Day, Activelle, Amabelz 0.5/0.1 28 Day, Angeliq 0.25/0.5 28 Day, Bijuva, Climara, Climara Pro, Combipatch, Divigel, Dotti, Elestrin, Estalis, Estrace, Estradot, Estring, Estrogel, Etyqa 0.5/0.1 28 Day, Evamist, Imvexxy 4 Mcg Starter Pack, Lopreeza 1/0.5 28 Day, Lyllana, Menostar, Mimvey, Minivelle, Myfembree, Oesclim, Oriahnn 28 Day Kit, Prefest 30 Day, Vagifem, Vivelle, Yuvafem
- Drug Type
- Small Molecule
- Chemical Formula
- C18H24O2
- CAS Number
- 50-28-2
- Unique Ingredient Identifier
- 4TI98Z838E
- Background
Estradiol is a naturally occurring hormone circulating endogenously in females. It is commercially available in several hormone therapy products for managing conditions associated with reduced estrogen, such as vulvovaginal atrophy and hot flashes. Some available forms of estradiol include oral tablets, injections, vaginal rings, transdermal patches, sprays,...
- Indication
Estradiol is indicated in various preparations for the treatment of moderate to severe vasomotor symptoms and vulvar and vaginal atrophy due to menopause, for the treatment of hypoestrogenism due to hypogonadism, castration, or primary ovarian failure, and for the prevention of postmenopausal osteoporosis. It is also used for the treatment of breast cancer (...
- Associated Conditions
- Atrophic Vaginitis, Breast Cancer, Breast engorgement caused by Postpartum state, Heavy Menstrual Bleeding, Hypogonadism female, Kraurosis Vulvae, Metastatic Breast Cancer, Osteoporosis, Postmenopausal Osteoporosis, Premature Ovarian Failure (POF), Prostate Cancer, Severe Pain, Urogenital atrophy, Vasomotor Symptoms Associated With Menopause, Vulvo Vaginal Atrophy, Advanced androgen dependent Prostate cancer, Female castration, Hypoestrogenism
- Associated Therapies
- Contraception, Hormone Replacement Therapy, Palliative Treatment
Comparative Study to Evaluate the Efficacy and Safety of the Fixed-dose Combination of Estradiol / Dydrogesterone in Perimenopausal Women
- Conditions
- Interventions
- First Posted Date
- 2021-12-14
- Last Posted Date
- 2022-01-06
- Target Recruit Count
- 150
- Registration Number
- NCT05156814
- Locations
- 🇷🇺
Federal State Budget Institution "National Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V.I.Kulakov", Moscow, Russian Federation
Tamoxifen Versus Estradiol for Unscheduled Bleeding in Etonogestrel Implant Users, a Randomized Pilot Trial
- Conditions
- Interventions
- First Posted Date
- 2021-06-21
- Last Posted Date
- 2022-06-03
- Lead Sponsor
- Virginia Commonwealth University
- Registration Number
- NCT04933240
- Locations
- 🇺🇸
Virginia Commonwealth University, Richmond, Virginia, United States
🇺🇸Shanthi Ramesh, Richmond, Virginia, United States
Gonadotropin Releasing Hormone Agonist (GnRHa) Versus Estrogen and Progesterone for Luteal Support in High Responders
- First Posted Date
- 2021-03-15
- Last Posted Date
- 2021-04-01
- Lead Sponsor
- Assaf-Harofeh Medical Center
- Target Recruit Count
- 100
- Registration Number
- NCT04797338
- Locations
- 🇮🇱
Shamir Medical center, Be'er Ya'aqov, Israel
A Randomized, Single Center Pilot Study Comparing Hyaluronic Acid to Vaginal Estrogen for Treatment of Genitourinary Syndrome of Menopause
- Conditions
- Interventions
- First Posted Date
- 2020-09-10
- Last Posted Date
- 2023-10-13
- Lead Sponsor
- NYU Langone Health
- Target Recruit Count
- 49
- Registration Number
- NCT04544475
- Locations
- 🇺🇸
NYU Langone Health, New York, New York, United States
Fractional CO2 Vaginal LASER Therapy for Recurrent Urinary Tract Infection
- Conditions
- Interventions
- First Posted Date
- 2020-03-10
- Last Posted Date
- 2024-03-26
- Lead Sponsor
- Mayo Clinic
- Target Recruit Count
- 12
- Registration Number
- NCT04301934
- Locations
- 🇺🇸
Mayo Clinic in Arizona, Phoenix, Arizona, United States
Neurobiology of Bulimia Nervosa
- Conditions
- Interventions
- First Posted Date
- 2020-01-13
- Last Posted Date
- 2022-07-26
- Lead Sponsor
- University of North Carolina, Chapel Hill
- Target Recruit Count
- 10
- Registration Number
- NCT04225221
- Locations
- 🇺🇸
University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States
Estrogen and Fear in PTSD
- First Posted Date
- 2019-12-10
- Last Posted Date
- 2024-08-15
- Lead Sponsor
- NYU Langone Health
- Target Recruit Count
- 80
- Registration Number
- NCT04192266
- Locations
- 🇺🇸
University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, United States
Estradiol as add-on to Antipsychotics
- Conditions
- Interventions
- First Posted Date
- 2019-09-18
- Last Posted Date
- 2020-05-26
- Lead Sponsor
- Tangent Data
- Target Recruit Count
- 100
- Registration Number
- NCT04093518
- Locations
- 🇲🇩
Centrul Comunitar de Sănătate Mintală Botanica, Chisinau, Moldova, Republic of
Discontinuation of Postmenopausal Hormone Therapy: Impact on the Cardiovascular System and Quality of Life
- Conditions
- Interventions
- First Posted Date
- 2019-08-08
- Last Posted Date
- 2021-02-15
- Lead Sponsor
- Hanna Savolainen-Peltonen
- Target Recruit Count
- 150
- Registration Number
- NCT04050592
- Locations
- 🇫🇮
HUS Women's Hospital, Helsinki, Finland
Estradiol Patch as add-on to Antipsychotics in Patients With Schizophrenia, Schizoaffective or Schizophreniform Disorder
- Conditions
- Interventions
- First Posted Date
- 2019-02-20
- Last Posted Date
- 2020-05-22
- Lead Sponsor
- Tangent Data
- Target Recruit Count
- 209
- Registration Number
- NCT03848234
- Locations
- 🇲🇩
Clinical Psychiatric Hospital, Codru, Chisinau, Moldova, Republic of
Drug Development Updates
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