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Travoprost

Generic Name
Travoprost
Brand Names
Duotrav, Izba, Travatan
Drug Type
Small Molecule
Chemical Formula
C26H35F3O6
CAS Number
157283-68-6
Unique Ingredient Identifier
WJ68R08KX9
Background

Travoprost ophthalmic solution is a topical medication used for controlling the progression of glaucoma or ocular hypertension, by reducing intraocular pressure . It is a synthetic prostaglandin F2alpha analog . Having been a well-received therapeutic agent with demonstrated efficacy and safety, travoprost is currently approved by the US FDA as a first-line treatment for lowering intraocular pressure in patients with open-angle glaucoma or ocular hypotension . Furthermore, this approval also solidifies the medication as the first and only prostaglandin analog approved by the FDA for first-line treatment of glaucoma patients that does not contain the preservative benzalkonium chloride . Moreover, travoprost is also currently approved in the EU for the decrease of elevated intraocular pressure in paediatric patients aged 2 months to < 18 years with ocular hypertension or paediatric glaucoma .

Indication

Travoprost ophthalmic solution is indicated for the reduction of elevated intraocular pressure in patients with open-angle glaucoma or ocular hypertension .

Travoprost is also currently indicated for the decrease of elevated intraocular pressure in paediatric patients aged 2 months to < 18 years with ocular hypertension or paediatric glaucoma .

Associated Conditions
Increased Intra Ocular Pressure (IOP)

Travoprost Ophthalmic Topical Cream for Open-angle Glaucoma or Ocular Hypertension

First Posted Date
2023-12-01
Last Posted Date
2023-12-06
Lead Sponsor
Glaukos Corporation
Target Recruit Count
250
Registration Number
NCT06152861
Locations
🇺🇸

Glaukos Clinical Study Site, Newport Beach, California, United States

Travoprost Intraocular Implant + iStent Infinite vs. iStent Infinite Alone

Phase 3
Recruiting
Conditions
Glaucoma, Open-Angle
Interventions
Other: Sham procedure
Device: iStent infinite
First Posted Date
2023-10-04
Last Posted Date
2023-10-04
Lead Sponsor
Glaukos Corporation
Target Recruit Count
150
Registration Number
NCT06066645
Locations
🇺🇸

Glaukos Clinical Study Site, Colorado Springs, Colorado, United States

Interval Intraocular Pressure in Intravitreal Injection Study

Not Applicable
Completed
Conditions
Glaucoma
Intraocular Pressure
Interventions
First Posted Date
2021-04-30
Last Posted Date
2021-04-30
Lead Sponsor
The University of Hong Kong
Target Recruit Count
64
Registration Number
NCT04868175
Locations
🇭🇰

HKSDS Program, Hong Kong, Hong Kong

Study of Exchange of Travoprost Intraocular Implant

Phase 2
Completed
Conditions
Open Angle Glaucoma
Interventions
First Posted Date
2020-11-04
Last Posted Date
2023-09-26
Lead Sponsor
Glaukos Corporation
Target Recruit Count
33
Registration Number
NCT04615403
Locations
🇺🇸

The Eye Associates of Manatee, Manatee, Florida, United States

🇺🇸

North Bath Eye Associates, Inc., Petaluma, California, United States

🇺🇸

Center for Sight, Sarasota, Florida, United States

and more 11 locations

Comparison Between Latanoprost , Travoprost and Tafluprost in Reducing IOP Fluctuation in POAG Patients

First Posted Date
2020-07-08
Last Posted Date
2020-07-08
Lead Sponsor
Kasr El Aini Hospital
Target Recruit Count
60
Registration Number
NCT04461249
Locations
🇪🇬

Kasr El-Aini hospital, Cairo, Egypt

Choroidal Thickness and Its Correlations With Ocular Parameters in Primary Open-angle Glaucoma

First Posted Date
2019-05-29
Last Posted Date
2019-05-29
Lead Sponsor
Afyon Kocatepe University Hospital
Target Recruit Count
96
Registration Number
NCT03966560

Safety and Tolerability of the Ophthalmic Solution PRO-179 Compared With Travatan®

Phase 1
Completed
Conditions
Glaucoma
Interventions
First Posted Date
2019-05-28
Last Posted Date
2019-12-12
Lead Sponsor
Laboratorios Sophia S.A de C.V.
Target Recruit Count
24
Registration Number
NCT03965052
Locations
🇲🇽

Jose Navarro Partida, Guadalajara, Jalisco, Mexico

Additive Effect of Twice-daily Brinzolamide 1%/Brimonidine 0.2%Combination as an Adjunctive Therapy to Travoprost in Patients With Normal Tension Glaucoma

First Posted Date
2017-05-12
Last Posted Date
2019-02-25
Lead Sponsor
Novartis Pharmaceuticals
Target Recruit Count
1
Registration Number
NCT03150160
Locations
🇰🇷

Novartis Investigative Site, Seoul, Korea, Republic of

Phase 3 Study Evaluating Safety and Efficacy of OTX-TP in Subjects With OAG or OHT

Phase 3
Completed
Conditions
Open Angle Glaucoma
Ocular Hypertension
Interventions
Other: Placebo Vehicle
First Posted Date
2016-09-26
Last Posted Date
2021-10-11
Lead Sponsor
Ocular Therapeutix, Inc.
Target Recruit Count
565
Registration Number
NCT02914509
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