Naproxen

Generic Name: Naproxen

Brand Names: Aleve, Aleve PM, Aleve-D, Anaprox, Naprelan, Naprosyn, Sallus, Sudafed Sinus & Pain, Treximet, Vimovo

Drug Type: Small Molecule

Chemical Formula: C_₁₄H_₁₄O_₃

CAS Number: 22204-53-1

Unique Ingredient Identifier: 57Y76R9ATQ

Background: Naproxen is classified as a nonsteroidal anti-inflammatory dug (NSAID) and was initially approved for prescription use in 1976 and then for over-the-counter (OTC) use in 1994. It can effectively manage acute pain as well as pain related to rheumatic diseases, and has a well studied adverse effect profile. Given its overall tolerability and effectiveness, nap...

Indication: Naproxen is indicated for the management of rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, polyarticular juvenile idiopathic arthritis, tendinitis, bursitis, acute gout, primary dysmenorrhea, and for the relief of mild to moderate pain. Further, it is first-line therapy for osteoarthritis, acute gouty arthritis, dysmenorrhea, and musculoskelet...

Associated Conditions: Acute Gouty Arthritis, Acute Migraine, Ankylosing Spondylitis (AS), Back pain, Bursitis, Extra-Articular Rheumatism, Fever, Flu caused by Influenza, Headache, Juvenile Idiopathic Arthritis (JIA), Menstrual Distress (Dysmenorrhea), Migraine, Muscle Spasms, Nasal Congestion, Osteoarthritis (OA), Pain, Post Traumatic Pain, Postoperative pain, Primary Dysmenorrhoea, Rheumatoid Arthritis, Rheumatoid Arthritis, Juvenile, Seasonal Allergic Rhinitis, Sinusitis, Tendinitis, Toothache, Articular inflammation

Associated Therapies: -

Clinical Trials

The Effect of Non-Steroidal Anti-Inflammatory Drug Naproxen on Pleural Effusion Formation After Lung Resection

Phase 2

Terminated

Conditions: Pleural Effusion Malignant
Pleural Effusion

Interventions: Drug: Placebo
Drug: Naproxen

First Posted Date: 2012-06-06

Last Posted Date: 2018-02-15

Lead Sponsor: McMaster University

Target Recruit Count: 7

Registration Number: NCT01612975

Locations: 🇨🇦
St. Joseph's Healthcare Hamilton, Hamilton, Ontario, Canada

A Randomized Study of Three Medication Regimens for Acute Low Back Pain

Phase 4

Completed

Conditions: Acute Low Back Pain

Interventions: Drug: Naproxen
Drug: Oxycodone/ acetaminophen
Drug: Cyclobenzaprine

First Posted Date: 2012-04-30

Last Posted Date: 2018-07-31

Lead Sponsor: Montefiore Medical Center

Target Recruit Count: 323

Registration Number: NCT01587274

Locations: 🇺🇸
Montefiore Medical Center, Bronx, New York, United States

Trial of Naproxen to Evaluate Various Methods of Measuring Analgesic Effect in Osteoarthritis Pain of the Knee

Not Applicable

Conditions: Osteoarthritis, Knee

Interventions: Drug: Naproxen
Drug: Placebo

First Posted Date: 2012-03-20

Last Posted Date: 2012-03-22

Lead Sponsor: Analgesic Solutions

Target Recruit Count: 70

Registration Number: NCT01557816

Locations: 🇺🇸
Analgesic Solutions, Natick, Massachusetts, United States

Influence of Naproxen on Heterotropic Bone Formation Following Hip Arthroscopy

Early Phase 1

Completed

Conditions: Heterotopic Ossification

Interventions: Drug: placebo
Drug: Naproxen

First Posted Date: 2012-02-27

Last Posted Date: 2022-07-14

Lead Sponsor: University of Utah

Target Recruit Count: 108

Registration Number: NCT01539447

Locations: 🇺🇸
University of Utah Orthopedics Center, Salt Lake City, Utah, United States

Study to Evaluate the Efficacy of the Synera Patch Compared to Naproxen Sodium for Epicondylitis of the Elbow

Phase 4

Completed

Conditions: Epicondylitis of the Elbow

Interventions: Drug: Synera patch for 12hrs/day
Drug: Synera patch twice daily
Drug: Naproxen
Drug: Synera

First Posted Date: 2012-02-02

Last Posted Date: 2014-03-05

Lead Sponsor: International Clinical Research Institute

Target Recruit Count: 78

Registration Number: NCT01525043

Locations: 🇺🇸
International Clinical Research Institute, Overland Park, Kansas, United States

Comparison Of Ketorolac Tromethamine Versus Naproxen For Moderate to Severe Back Pain Treatment

Phase 3

Completed

Conditions: Back Pain

Interventions: Drug: Ketorolac Tromethamine
Drug: Naproxen

First Posted Date: 2011-11-16

Last Posted Date: 2021-02-24

Lead Sponsor: EMS

Target Recruit Count: 83

Registration Number: NCT01471886

Locations: 🇧🇷
IOT - Instituto de Ortopedia e Traumatologia, Sao Paulo, SP, Brazil

Comparison Of Ketorolac Tromethamine Oral Drops Versus Naproxen For Moderate to Severe Back Pain Treatment

Phase 3

Completed

Conditions: Back Pain

Interventions: Drug: Naproxen
Drug: Ketorolac Tromethamine

First Posted Date: 2011-11-16

Last Posted Date: 2021-02-24

Lead Sponsor: EMS

Target Recruit Count: 78

Registration Number: NCT01471899

Paradoxical Tuberculosis Immune Reconstitution Inflammatory Syndrome (TB-IRIS) Treatment Trial

Phase 2

Withdrawn

Conditions: Immune Reconstitution Inflammatory Syndrome
Immune Reconstitution Syndrome
Tuberculosis
HIV-infection/Aids

Interventions: Drug: Dexamethasone
Drug: Naproxen
Drug: Placebo
Drug: Atorvastatin

First Posted Date: 2011-09-28

Last Posted Date: 2013-11-25

Lead Sponsor: University of Minnesota

Registration Number: NCT01442428

Locations: 🇹🇭
Ramathibodi Hospital, Bangkok, Thailand
🇹🇭
Bamrasnaradura Infectious Diseases Institute, Nonthaburi, Thailand
🇹🇭
Chiang Mai University, Chiang Mai, Thailand