Mycophenolic acid
- Generic Name
- Mycophenolic acid
- Brand Names
- Myfortic
- Drug Type
- Small Molecule
- Chemical Formula
- C17H20O6
- CAS Number
- 24280-93-1
- Unique Ingredient Identifier
- HU9DX48N0T
- Background
Mycophenolic acid is a potent immunosuppressant agent that inhibits de novo purine biosynthesis. It was derived from Penicillium stoloniferum, and has also shown antibacterial, antifungal and antiviral properties.. Mycophenolic acid is used in immunosuppressive regimens as part of a triple therapy that includes a calcineurin inhibitor (ciclosporin or tacroli...
- Indication
Mycophenolic acid is an antimetabolite immunosuppressant indicated for prophylaxis of organ rejection in adult patients receiving kidney transplants and in pediatric patients at least 5 years of age and older who are at least 6 months post kidney transplant. Mycophenolic acid is used in combination with cyclosporine and corticosteroids.
- Associated Conditions
- Kidney Transplant Rejection
- Associated Therapies
- -
Treg Therapy in Subclinical Inflammation in Kidney Transplantation
- Conditions
- Interventions
- First Posted Date
- 2016-03-17
- Last Posted Date
- 2024-10-07
- Target Recruit Count
- 32
- Registration Number
- NCT02711826
- Locations
- 🇺🇸
University of California at San Francisco, San Francisco, California, United States
🇺🇸University of Alabama, Birmingham, Birmingham, Alabama, United States
🇺🇸University of Colorado Health Transplant Center - Anschutz, Aurora, Colorado, United States
Sirolimus Associated With Tacrolimus at Low Doses in Elderly Kidney Transplant Patients
- First Posted Date
- 2016-02-17
- Last Posted Date
- 2016-02-17
- Lead Sponsor
- Associação Médico Espírita de Botucatu
- Target Recruit Count
- 48
- Registration Number
- NCT02683291
Efficacy and Safety of a Reduced Immunosuppression vs. Standard Triple Therapy in Senior Renal Transplant Recipients
- First Posted Date
- 2015-05-27
- Last Posted Date
- 2017-08-09
- Lead Sponsor
- Klemens Budde
- Target Recruit Count
- 400
- Registration Number
- NCT02453867
The Mechanisms and Significances of Synergistic Effects of Mycophenolic Acid and LPS on IL-1β Secretion by Mononuclear
- Conditions
- First Posted Date
- 2015-05-06
- Last Posted Date
- 2015-05-06
- Target Recruit Count
- 10
- Registration Number
- NCT02435368
- Locations
- 🇨🇳
Third Affiliated Hospital of Southern Medical University, Guangzhou, Guangdong, China
Proportion of CMV Seropositive Kidney Transplant Recipients Who Will Develop a CMV Infection When Treated With an Immunosuppressive Regimen Including Everolimus and Reduced Dose of Cyclosporine Versus an Immunosuppressive Regimen With Mycophenolic Acid and Standard Dose of Cyclosporine A
- Conditions
- Interventions
- First Posted Date
- 2014-12-31
- Last Posted Date
- 2018-11-14
- Lead Sponsor
- University Hospital, Bordeaux
- Target Recruit Count
- 186
- Registration Number
- NCT02328963
- Locations
- 🇫🇷
Hôpital Edouard Herriot, Lyon, France
🇫🇷APHP - Hôpital Necker, Paris, France
🇫🇷CHU La Cavale Blanche, Brest, France
Nonmyeloablative Hematopoietic Cell Transplantation (HCT) for Patients With Hematologic Malignancies Using Related, HLA-Haploidentical Donors: A Pilot Trial of Peripheral Blood Stem Cells (PBSC) as the Donor Source
- First Posted Date
- 2014-06-19
- Last Posted Date
- 2019-10-15
- Lead Sponsor
- Rafic Farah, MD
- Target Recruit Count
- 28
- Registration Number
- NCT02167958
- Locations
- 🇺🇸
UPMC Hillman Cancer Center, Pittsburgh, Pennsylvania, United States
Belatacept Compared to Tacrolimus in Deceased Donor Renal Transplant Recipients
- Conditions
- Interventions
- First Posted Date
- 2014-06-02
- Last Posted Date
- 2021-02-10
- Lead Sponsor
- Columbia University
- Target Recruit Count
- 57
- Registration Number
- NCT02152345
- Locations
- 🇺🇸
Columbia University Medical Center, New York, New York, United States
Belatacept in Kidney Transplantation of Moderately Sensitized Patients
- First Posted Date
- 2014-05-05
- Last Posted Date
- 2018-12-17
- Lead Sponsor
- University of Wisconsin, Madison
- Registration Number
- NCT02130817
- Locations
- 🇺🇸
University of Wiscsonsin Hospital and Clinics, Madison, Wisconsin, United States
Safety and Efficacy of Basiliximab, Delayed Dose Tacrolimus Plus ECMPA (Enteric Coated Mycophenolic Acid) Following Liver Transplantation
- Conditions
- Interventions
- First Posted Date
- 2014-04-25
- Last Posted Date
- 2022-09-29
- Lead Sponsor
- University of California, Los Angeles
- Target Recruit Count
- 59
- Registration Number
- NCT02123108
- Locations
- 🇺🇸
Ronald Reagan UCLA Medical Center, Los Angeles, California, United States
Safety and Efficacy of Everolimus Treatment in Liver Transplantation for Liver Cancer
- Conditions
- Interventions
- First Posted Date
- 2014-03-07
- Last Posted Date
- 2024-01-30
- Lead Sponsor
- Baylor Research Institute
- Target Recruit Count
- 336
- Registration Number
- NCT02081755
- Locations
- 🇺🇸
Washington University School of Medicine, Saint Louis, Missouri, United States
🇺🇸Mayo Clinic, Rochester, Minnesota, United States
🇺🇸Northwestern University School of Medicine, Chicago, Illinois, United States
Drug Development Updates
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