Hydrocortisone
- Generic Name
- Hydrocortisone
- Brand Names
- Ala-cort, Ala-scalp, Alcortin, Alkindi, Anusol HC, Aquanil HC, Casporyn HC, Cipro, Cipro HC, Colocort, Cortaid, Cortane-B, Cortef, Cortenema, Cortisporin, Cortizone-10, Dermacort, Dermarest Eczema, Dermazene, Home Papkit, Hydroskin, Monistat Itch Relief, Neosporin Eczema, Preparation H Hydrocortisone, Procto-med, Procto-pak, Proctocort, Proctol, Proctosedyl, Proctosol, Proctozone HC, Scalpicin Itch Relief, Texacort, Vanoxide-HC, Xerese, Plenadren, Efmody
- Drug Type
- Small Molecule
- Chemical Formula
- C21H30O5
- CAS Number
- 50-23-7
- Unique Ingredient Identifier
- WI4X0X7BPJ
- Background
Hydrocortisone, or cortisol, is a glucocorticoid secreted by the adrenal cortex. Hydrocortisone is used to treat immune, inflammatory, and neoplastic conditions. It was discovered in the 1930s by Edward Kendall and named Compound F, or 17-hydroxycorticosterone.
Hydrocortisone was granted FDA approval on 5 August 1952.
- Indication
Otic solutions are indicated for infections of the external auditory canal caused by susceptible organisms and with inflammation. Hydrocortisone tablets are indicated for certain endocrine, rheumatic, collagen, allergic, ophthalmic, respiratory, hematologic, neoplastic, edematous, gastrointestinal, and other conditions. A hydrocortisone enema is indicated for ulcerative colitis, a topical ointment with antibiotics is indicated for corticosteroid responsive dermatoses with infections, and a topical cream with acyclovir is indicated to treat cold sores. Oral granules of hydrocortisone are used as a replacement therapy for Adrenocortical Insufficiency (AI) in children under 17 years of age.
- Associated Conditions
- Acute Gouty Arthritis, Acute Leukemia, Acute Otitis Externa, Adrenal Insufficiency, Allergic Conjunctivitis (AC), Allergic Rhinitis (AR), Allergic corneal marginal ulcers, Ankylosing Spondylitis (AS), Aspiration Pneumonitis, Asthma, Atopic Dermatitis, Berylliosis, Bullous dermatitis herpetiformis, Chorioretinitis, Choroiditis, Congenital Adrenal Hyperplasia (CAH), Congenital Hypoplastic Anemia, Contact Dermatitis, Crohn's Disease (CD), Dermatitis, Dermatomyositis (DM), Dermatosis, Drug hypersensitivity reaction, Epicondylitis, Erythroblastopenia, Fissure;Anal, Haemorrhoids, Herpes Labialis, Hypercalcemia of Malignancy, Immune Thrombocytopenia (ITP), Infection of the Fenestration Cavity, Infection of the Mastoidectomy Cavity, Iridocyclitis, Iritis, Itching caused by Hemorrhoids, Itching of the Anus, Keratitis, Leukemias, Loeffler's syndrome, Lymphoma, Lymphomas NEC, Mycosis Fungoides (MF), Ophthalmia, Sympathetic, Optic Neuritis, Pain caused by Hemorrhoids, Pemphigus, Posterior Uveitis, Posttraumatic Osteoarthritis, Primary adrenocortical insufficiency, Proctitis, Proteinuria, Pruritis of the skin, Psoriatic Arthritis, Rectal inflammations NEC, Rheumatic heart disease, unspecified, Rheumatoid Arthritis, Rheumatoid Arthritis, Juvenile, Secondary adrenocortical insufficiency, Secondary thrombocytopenia, Serum Sickness, Severe Seborrheic Dermatitis, Skin Diseases, Stevens-Johnson Syndrome, Synovitis, Systemic Lupus Erythematosus, Trichinosis, Tuberculous Meningitis, Ulcerative Colitis, Acquired immune hemolytic anemia, Acute Bursitis, Acute Tenosynovitis, Acute rheumatic carditis, Anterior eye segment inflammation, Cryptitis, Disseminated Pulmonary Tuberculosis (TB), Exfoliative erythroderma, Fulminating Pulmonary Tuberculosis, Non-suppurative Thyroiditis, Severe Erythema multiforme, Severe Psoriasis, Subacute Bursitis, Superficial infection of the external auditory canal with inflammation, Symptomatic Sarcoidosis, Systemic Dermatomyositis, Varicella-zoster virus acute retinal necrosis
- Associated Therapies
- Palliative Treatment
Effect of Postop Steroids on Cardiovascular/Respiratory Function in Neonates Undergoing Cardiopulmonary Bypass
- Conditions
- Interventions
- First Posted Date
- 2012-05-10
- Last Posted Date
- 2015-11-10
- Lead Sponsor
- University of Alabama at Birmingham
- Target Recruit Count
- 40
- Registration Number
- NCT01595386
- Locations
- 🇺🇸
University of Alabama at Birmingham, Birmingham, Alabama, United States
Glucocorticoid Treatment for Social Phobia
- Conditions
- Interventions
- First Posted Date
- 2012-04-10
- Last Posted Date
- 2012-12-05
- Lead Sponsor
- Insel Gruppe AG, University Hospital Bern
- Target Recruit Count
- 66
- Registration Number
- NCT01574014
- Locations
- 🇨🇭
Dep. of Psychiatric Neurophysiology, University Hospital of Psychiatry, University of Bern, Bern, Switzerland
Hydrocortisone Replacement in Patients With Secondary Adrenal Insufficiency (SUPREME CORT)
- First Posted Date
- 2012-03-07
- Last Posted Date
- 2014-07-14
- Lead Sponsor
- University Medical Center Groningen
- Target Recruit Count
- 63
- Registration Number
- NCT01546922
- Locations
- 🇳🇱
University Medical Centre Groningen, Groningen, Netherlands
Cortisone Treatment for the Prevention of Postoperative Pancreatitis and Pancreatitis-induced Complications After Pancreaticoduodenectomy and Distal Pancreatic Resection
- Conditions
- First Posted Date
- 2011-10-27
- Last Posted Date
- 2018-11-29
- Lead Sponsor
- Tampere University Hospital
- Registration Number
- NCT01460615
- Locations
- 🇫🇮
Tampere University Hospital, Tampere, Finland
NHL16: Study For Newly Diagnosed Patients With Acute Lymphoblastic Lymphoma
- Conditions
- Interventions
- First Posted Date
- 2011-10-13
- Last Posted Date
- 2022-06-28
- Lead Sponsor
- St. Jude Children's Research Hospital
- Target Recruit Count
- 23
- Registration Number
- NCT01451515
- Locations
- 🇺🇸
Rady Children's Hospital San Diego, San Diego, California, United States
🇺🇸St. Jude Children's Research Hospital, Memphis, Tennessee, United States
ADjunctive coRticosteroid trEatment iN criticAlly ilL Patients With Septic Shock
- Conditions
- Interventions
- First Posted Date
- 2011-10-07
- Last Posted Date
- 2017-12-12
- Lead Sponsor
- The George Institute
- Target Recruit Count
- 3800
- Registration Number
- NCT01448109
- Locations
- 🇦🇺
Royal Prince Alfred Hospital, Camperdown, New South Wales, Australia
🇦🇺The George Institute for Global Health, Sydney, New South Wales, Australia
🇦🇺Royal Brisbane and Women's Hospital, Herston, Queensland, Australia
Effect of Short Term Adrenal Suppression on Androgen Overproduction in Overweight Girls With Androgen Excess
- Conditions
- Interventions
- First Posted Date
- 2011-08-24
- Last Posted Date
- 2018-07-19
- Lead Sponsor
- University of Virginia
- Registration Number
- NCT01422707
- Locations
- 🇺🇸
University of Virginia Center for Research in Reproduction, Charlottesville, Virginia, United States
Effect of Longer-term Adrenal Suppression Using Low Dose Hydrocortisone on Androgen Overproduction
- Conditions
- Interventions
- First Posted Date
- 2011-08-24
- Last Posted Date
- 2018-07-19
- Lead Sponsor
- University of Virginia
- Registration Number
- NCT01422733
- Locations
- 🇺🇸
University of Virginia Center for Research in Reproduction, Charlottesville, Virginia, United States
Steroids in Bilateral Total Knee Replacement
- Conditions
- Interventions
- First Posted Date
- 2011-07-21
- Last Posted Date
- 2017-07-31
- Lead Sponsor
- Hospital for Special Surgery, New York
- Target Recruit Count
- 30
- Registration Number
- NCT01399268
- Locations
- 🇺🇸
Hospital for Special Surgery, New York, New York, United States
Hydrocortisone for BPD
- Conditions
- Interventions
- First Posted Date
- 2011-05-13
- Last Posted Date
- 2024-07-18
- Lead Sponsor
- NICHD Neonatal Research Network
- Target Recruit Count
- 800
- Registration Number
- NCT01353313
- Locations
- 🇺🇸
University of California - Los Angeles, Los Angeles, California, United States
🇺🇸Emory University, Atlanta, Georgia, United States
🇺🇸Stanford University, Palo Alto, California, United States
Drug Development Updates
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