Hydrocortisone

Generic Name: Hydrocortisone

Brand Names: Ala-cort, Ala-scalp, Alcortin, Alkindi, Anusol HC, Aquanil HC, Casporyn HC, Cipro, Cipro HC, Colocort, Cortaid, Cortane-B, Cortef, Cortenema, Cortisporin, Cortizone-10, Dermacort, Dermarest Eczema, Dermazene, Home Papkit, Hydroskin, Monistat Itch Relief, Neosporin Eczema, Preparation H Hydrocortisone, Procto-med, Procto-pak, Proctocort, Proctol, Proctosedyl, Proctosol, Proctozone HC, Scalpicin Itch Relief, Texacort, Vanoxide-HC, Xerese, Plenadren, Efmody

Drug Type: Small Molecule

Chemical Formula: C_₂₁H_₃₀O_₅

CAS Number: 50-23-7

Unique Ingredient Identifier: WI4X0X7BPJ

Background: Hydrocortisone, or cortisol, is a glucocorticoid secreted by the adrenal cortex. Hydrocortisone is used to treat immune, inflammatory, and neoplastic conditions. It was discovered in the 1930s by Edward Kendall and named Compound F, or 17-hydroxycorticosterone.

Hydrocortisone was granted FDA approval on 5 August 1952.

Indication: Otic solutions are indicated for infections of the external auditory canal caused by susceptible organisms and with inflammation. Hydrocortisone tablets are indicated for certain endocrine, rheumatic, collagen, allergic, ophthalmic, respiratory, hematologic, neoplastic, edematous, gastrointestinal, and other conditions. A hydrocortisone enema is indicated fo...

Associated Conditions: Acute Gouty Arthritis, Acute Leukemia, Acute Otitis Externa, Adrenal Insufficiency, Allergic Conjunctivitis (AC), Allergic Rhinitis (AR), Allergic corneal marginal ulcers, Ankylosing Spondylitis (AS), Aspiration Pneumonitis, Asthma, Atopic Dermatitis, Berylliosis, Bullous dermatitis herpetiformis, Chorioretinitis, Choroiditis, Congenital Adrenal Hyperplasia (CAH), Congenital Hypoplastic Anemia, Contact Dermatitis, Crohn's Disease (CD), Dermatitis, Dermatomyositis (DM), Dermatosis, Drug hypersensitivity reaction, Epicondylitis, Erythroblastopenia, Fissure;Anal, Haemorrhoids, Herpes Labialis, Hypercalcemia of Malignancy, Immune Thrombocytopenia (ITP), Infection of the Fenestration Cavity, Infection of the Mastoidectomy Cavity, Iridocyclitis, Iritis, Itching caused by Hemorrhoids, Itching of the Anus, Keratitis, Leukemias, Loeffler's syndrome, Lymphoma, Lymphomas NEC, Mycosis Fungoides (MF), Ophthalmia, Sympathetic, Optic Neuritis, Pain caused by Hemorrhoids, Pemphigus, Posterior Uveitis, Posttraumatic Osteoarthritis, Primary adrenocortical insufficiency, Proctitis, Proteinuria, Pruritis of the skin, Psoriatic Arthritis, Rectal inflammations NEC, Rheumatic heart disease, unspecified, Rheumatoid Arthritis, Rheumatoid Arthritis, Juvenile, Secondary adrenocortical insufficiency, Secondary thrombocytopenia, Serum Sickness, Severe Seborrheic Dermatitis, Skin Diseases, Stevens-Johnson Syndrome, Synovitis, Systemic Lupus Erythematosus, Trichinosis, Tuberculous Meningitis, Ulcerative Colitis, Acquired immune hemolytic anemia, Acute Bursitis, Acute Tenosynovitis, Acute rheumatic carditis, Anterior eye segment inflammation, Cryptitis, Disseminated Pulmonary Tuberculosis (TB), Exfoliative erythroderma, Fulminating Pulmonary Tuberculosis, Non-suppurative Thyroiditis, Severe Erythema multiforme, Severe Psoriasis, Subacute Bursitis, Superficial infection of the external auditory canal with inflammation, Symptomatic Sarcoidosis, Systemic Dermatomyositis, Varicella-zoster virus acute retinal necrosis

Associated Therapies: Palliative Treatment

Clinical Trials

Ultra Violet B Radiation (UVR) Study of Strontium Chloride Hexahydrate Hydrocortisone

Phase 1

Completed

Conditions: Erythema
Pain

Interventions: Drug: Hydrocortisone
Drug: 2PX+
Drug: 2PX-

First Posted Date: 2011-02-23

Last Posted Date: 2011-06-29

Lead Sponsor: X-pert Med GmbH

Target Recruit Count: 47

Registration Number: NCT01301677

Locations: 🇩🇪
X-pert Med Gmbh, Jena, Thuringia, Germany
🇩🇪
X-pert Med GmbH, Graefelfing, Bavaria, Germany

Efficacy of Hydrocortisone in Treatment of Severe Sepsis/Septic Shock Patients With Acute Lung Injury/Acute Respiratory Distress Syndrome (ARDS)

Not Applicable

Completed

Conditions: Septic Shock
Severe Sepsis
Acute Respiratory Distress Syndrome
Acute Lung Injury

Interventions: Drug: Placebo
Drug: Hydrocortisone

First Posted Date: 2011-01-27

Last Posted Date: 2015-04-20

Lead Sponsor: Mahidol University

Target Recruit Count: 197

Registration Number: NCT01284452

Locations: 🇹🇭
Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand

EZN-3042 Administered With Re-induction Chemotherapy in Children With Relapsed Acute Lymphoblastic Leukemia (ALL)

Phase 1

Terminated

Conditions: Lymphoblastic Leukemia, Acute
Leukemia, Lymphoblastic, Acute
Lymphoblastic Leukemia, Acute, Childhood
Leukemia, Lymphoblastic, Acute, T Cell

Interventions: Drug: EZN-3042
Drug: Cytarabine
Drug: Doxorubicin
Drug: Prednisone
Drug: Vincristine
Drug: PEG-asparaginase
Drug: Methotrexate
Drug: Hydrocortisone

First Posted Date: 2010-08-23

Last Posted Date: 2024-02-01

Lead Sponsor: Therapeutic Advances in Childhood Leukemia Consortium

Target Recruit Count: 6

Registration Number: NCT01186328

Locations: 🇦🇺
Sydney Children's Hospital, Sydney, Australia
🇺🇸
St. Jude, Memphis, Tennessee, United States
🇺🇸
Childrens Hospital Los Angeles, Los Angeles, California, United States

and more 4 locations

Anti-inflammatory Treatment at the Onset of Necrotizing Enterocolitis (NEC) in Preterm Infants

Not Applicable

Terminated

Conditions: Necrotizing Enterocolitis

Interventions: Drug: placebo
Drug: hydrocortisone

First Posted Date: 2010-07-02

Last Posted Date: 2020-09-09

Lead Sponsor: NorthShore University HealthSystem

Target Recruit Count: 2

Registration Number: NCT01156480

Locations: 🇺🇸
NorthShore University HealthSystem, Evanston, Illinois, United States
🇺🇸
University of Chicago Comer Childrens Hospital, Chicago, Illinois, United States

Hemodynamic and Inflammatory Effects of Abrupt Versus Tapered Corticosteroid Discontinuation in Septic Shock

Phase 4

Terminated

Conditions: Septic Shock

Interventions: Drug: hydrocortisone
Drug: Normal Saline

First Posted Date: 2010-06-25

Last Posted Date: 2018-04-02

Lead Sponsor: The Cleveland Clinic

Target Recruit Count: 11

Registration Number: NCT01150409

Locations: 🇺🇸
Cleveland Clinic, Cleveland, Ohio, United States

Hybrid Immunotherapy for Hemophagocytic LymphoHistiocytosis

Phase 2

Completed

Conditions: Hemophagocytic Lymphohistiocytosis

Interventions: Drug: ATG, rabbit
Drug: Etoposide
Drug: Methotrexate
Drug: hydrocortisone
Drug: Dexamethasone

First Posted Date: 2010-04-15

Last Posted Date: 2020-10-19

Lead Sponsor: Children's Hospital Medical Center, Cincinnati

Target Recruit Count: 31

Registration Number: NCT01104025

Locations: 🇺🇸
Phoenix Children's Hospital, Phoenix, Arizona, United States
🇺🇸
Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, United States
🇺🇸
Oregon Health and Science University, Portland, Oregon, United States

and more 11 locations

RituxiMab INDuction in Renal Transplantation

Phase 4

Conditions: Function of Renal Transplant

Interventions: Drug: Tacrolimus
Drug: Rituximab
Drug: Mycophenylate mofetil
Drug: Hydrocortisone
Drug: Prednisolone

First Posted Date: 2010-03-30

Last Posted Date: 2020-07-22

Lead Sponsor: Guy's and St Thomas' NHS Foundation Trust

Target Recruit Count: 100

Registration Number: NCT01095172

Locations: 🇬🇧
Central Manchester University Hospitals NHS Foundation Trust, Manchester, United Kingdom
🇬🇧
East Kent Hospitals NHS Foundation Trust, Canterbury, Kent, United Kingdom
🇬🇧
Glasgow Renal and Transplant Unit, Glasgow, United Kingdom

and more 3 locations