Nifedipine

Generic Name: Nifedipine

Brand Names: Adalat, Afeditab CR, Nifediac, Nifedical, Procardia

Drug Type: Small Molecule

Chemical Formula: C_₁₇H_₁₈N_₂O_₆

CAS Number: 21829-25-4

Unique Ingredient Identifier: I9ZF7L6G2L

Background: Nifedipine, or BAY a 1040, is a first generation dihydropyridine L-type calcium channel blocker, similar to nicardipine. Nifedipine was developed by Bayer and first described in the literature, along with other dihydropyridines, in 1972. Since nifedipine's development, second and third generation dihydropyridines have been developed with slower onsets and longer durations of action. The most popular of the third generation dihydropyridines is amlodipine.

Nifedipine was granted FDA approval on 31 December 1981.

Indication: Nifedipine capsules are indicated to treat vasospastic angina and chronic stable angina. Extended release tablets are indicated to treat vasospastic angina, chronic stable angina, and hypertension.

Associated Conditions: Achalasia, Chronic Stable Angina Pectoris, Fissure;Anal, Hypertension, Hypertensive Emergency, Premature Labour, Proctalgia, Pulmonary Edemas, Pulmonary Hypertension (PH), Raynaud's Phenomenon, Ureteral Calculus, Vasospastic Angina

Associated Therapies: -

Clinical Trials

Transdermal Nitroglycerin and Nifedipine in Preterm Labor

Phase 4

Completed

Conditions: Managing Preterm Labor

Interventions: Drug: Transdermal nitroglycerin
Drug: nifedipine

First Posted Date: 2015-10-22

Last Posted Date: 2015-10-22

Lead Sponsor: Shiraz University of Medical Sciences

Target Recruit Count: 112

Registration Number: NCT02583633

The Effects of Doxazosin and Nifedipine on Blood Pressure Variability and Uric Acid in Plasma in Hypertensive Patients

Phase 2

Conditions: Hypertension

Interventions: Drug: Doxazosin
Drug: Nifedipine

First Posted Date: 2015-09-30

Last Posted Date: 2016-07-28

Lead Sponsor: First Affiliated Hospital of Harbin Medical University

Target Recruit Count: 30

Registration Number: NCT02563405

Locations: 🇨🇳
uric acid test and 24-hour ambulatory BP monitoring, Harbin, Heilongjiang, China

Early Vascular Adjustments During Hypertensive Pregnancy

Phase 4

Conditions: Hypertension, Pregnancy-Induced
Pre-Eclampsia

Interventions: Drug: Labetalol
Drug: Nifedipine
Drug: Methyldopa

First Posted Date: 2015-08-24

Last Posted Date: 2021-03-24

Lead Sponsor: Maastricht University Medical Center

Target Recruit Count: 368

Registration Number: NCT02531490

Locations: 🇳🇱
Maastricht UMC, Maastricht, Netherlands

The Effect of Intra-anal Nifedipine, Used As Add-on to Conservative Therapy, on Pain in Patients With Anal Fissure

Phase 2

Completed

Conditions: Chronic Anal Fissure

Interventions: Drug: Nifedipine

First Posted Date: 2015-08-18

Last Posted Date: 2018-10-23

Lead Sponsor: RDD Pharma Ltd

Target Recruit Count: 339

Registration Number: NCT02527109

Locations: 🇧🇬
MC Health BG EOOD, Sofia, Bulgaria
🇧🇬
MC "New rehabilitation centre'' EOOD, Stara Zagora, Bulgaria
🇧🇬
"Multiprofile Regional Hospital for Active Treatment - Dr. St. Cherkezov" AD Department of Gastroenterology, Veliko Tarnovo, Bulgaria

and more 21 locations