Nitrite

Generic Name: Nitrite

Drug Type: Small Molecule

Chemical Formula: NO_₂

CAS Number: 14797-65-0

Unique Ingredient Identifier: J39976L608

Background: Nitrite is under investigation for the treatment of Heart Failure.

Clinical Trials

Comparison of Squat-to-Stand Maneuver With Amyl Nitrite, Valsalva, and Exercise Stress Echocardiography in Inducing Latent Left Ventricular Outflow Obstruction in Hypertrophic Cardiomyopathy

Not Applicable

Withdrawn

Conditions: Hypertrophic Cardiomyopathy
Cardiomyopathy, Hypertrophic
Hypertrophic Obstructive Cardiomyopathy

Interventions: Other: Squat-to-stand maneuver
Drug: Amyl nitrite inhalation
Other: Valsalva

First Posted Date: 2021-05-27

Last Posted Date: 2022-01-11

Lead Sponsor: Mayo Clinic

Registration Number: NCT04905173

Treatment of Lung Injury From COVID-19 Infection With Intravenous Sodium Nitrite

Phase 2

Withdrawn

Conditions: COVID-19
Acute Respiratory Distress Syndrome
Acute Respiratory Failure

Interventions: Drug: Sodium Nitrite
Drug: Normal Saline

First Posted Date: 2020-05-26

Last Posted Date: 2020-09-16

Lead Sponsor: Hope Pharmaceuticals

Registration Number: NCT04401527

Locations: 🇺🇸
Participating Research Facility, Fort Worth, Texas, United States

The Nitrite and Coronary Flow Study

Phase 1

Completed

Conditions: Cardiovascular Diseases
Vasodilation
Hypoxia

Interventions: Drug: Sodium Nitrite

First Posted Date: 2020-04-21

Last Posted Date: 2020-04-21

Lead Sponsor: University of East Anglia

Target Recruit Count: 14

Registration Number: NCT04354051

Locations: 🇬🇧
University of East Anglia, Norwich, Norfolk, United Kingdom

Nitrite Infusion in Children With Malaria

Phase 1

Withdrawn

Conditions: Falciparum Malaria

Interventions: Drug: Sodium Nitrite

First Posted Date: 2020-02-28

Last Posted Date: 2021-03-16

Lead Sponsor: Duke University

Registration Number: NCT04289558

Locations: 🇹🇿
Hubert Kairuki Memorial University, Dar es Salaam, Tanzania

Nitrite Effects on Cardiac Muscle in CABG

Phase 2

Conditions: Coronary Artery Disease
Atherosclerosis
Diabetes Mellitus
Cardiac Disease
Vascular Diseases

Interventions: Drug: Sodium Nitrite
Drug: 0.9% Sodium-chloride

First Posted Date: 2019-06-28

Last Posted Date: 2019-06-28

Lead Sponsor: University of East Anglia

Target Recruit Count: 75

Registration Number: NCT04001283

Locations: 🇬🇧
Aberdeen Royal Infirmary, Aberdeen, Scotland, United Kingdom
🇬🇧
Papworth Hospital, Cambridge, United Kingdom

Nitrite Infusion in High Risk Patients Undergoing Cardiopulmonary Bypass

Phase 3

Withdrawn

Conditions: Acute Kidney Injury

Interventions: Drug: Saline
Drug: Sodium Nitrite

First Posted Date: 2017-11-06

Last Posted Date: 2018-09-27

Lead Sponsor: University of Alabama at Birmingham

Registration Number: NCT03331146

Locations: 🇺🇸
UAB Department of Anesthesiology and Perioperative Medicine, Birmingham, Alabama, United States

The Haem and Nitrite Study - The Effects of Haemoglobin NO-blockade on Nitrite-induced Forearm Vessel Dilatation

Phase 1

Conditions: Healthy Volunteers

Interventions: Drug: Sodium Nitrite

First Posted Date: 2017-03-13

Last Posted Date: 2017-03-20

Lead Sponsor: University of East Anglia

Target Recruit Count: 41

Registration Number: NCT03077763

Locations: 🇬🇧
University of East Anglia, Norwich, Norfolk, United Kingdom

Oral Nitrite in Patients With Pulmonary Hypertension and Heart Failure With Preserved Ejection Fraction

Phase 2

Completed

Conditions: Pulmonary Hypertension Secondary
Heart Failure

Interventions: Drug: Sodium Nitrite
Drug: Placebo Oral Capsule

First Posted Date: 2017-01-10

Last Posted Date: 2024-06-07

Lead Sponsor: University of Pittsburgh

Target Recruit Count: 33

Registration Number: NCT03015402

Locations: 🇺🇸
University of Pittsburgh, Pittsburgh, Pennsylvania, United States

Phase 1 Clinical Trial of Sodium Nitrite for Out of Hospital Cardiac Arrest

Phase 1

Completed

Conditions: Out-Of-Hospital Cardiac Arrest

First Posted Date: 2016-12-08

Last Posted Date: 2018-05-07

Lead Sponsor: University of Washington

Target Recruit Count: 120

Registration Number: NCT02987088

Locations: 🇺🇸
University of Washington, Seattle, Washington, United States

Oral Nitrite for Older Heart Failure With Preserved Ejection Fraction

Phase 2

Completed

Conditions: Heart Failure

Interventions: Drug: sodium nitrite
Drug: Control

First Posted Date: 2016-09-29

Last Posted Date: 2020-01-22

Lead Sponsor: Gladwin, Mark, MD

Target Recruit Count: 15

Registration Number: NCT02918552

Locations: 🇺🇸
UPMC Montefiore Hospital, Pittsburgh, Pennsylvania, United States

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