Nitrite

Generic Name: Nitrite

Drug Type: Small Molecule

Chemical Formula: NO_₂

CAS Number: 14797-65-0

Unique Ingredient Identifier: J39976L608

Background: Nitrite is under investigation for the treatment of Heart Failure.

Clinical Trials

Inhaled Sodium Nitrite on Heart Failure With Preserved Ejection Fraction

Phase 2

Completed

Conditions: Heart Failure

Interventions: Other: Placebo
Drug: Sodium Nitrite Inhalation Solution

First Posted Date: 2014-10-10

Last Posted Date: 2017-08-29

Lead Sponsor: Mayo Clinic

Target Recruit Count: 26

Registration Number: NCT02262078

Locations: 🇺🇸
Mayo Clinic in Rochester, Rochester, Minnesota, United States

Intravenous Nitrite Infusion for Reversal of Cerebral Vasospasm After Subarachnoid Hemorrhage

Phase 2

Terminated

Conditions: Subarachnoid Hemorrhage

Interventions: Drug: Sodium Nitrite

First Posted Date: 2014-06-27

Last Posted Date: 2018-03-30

Lead Sponsor: Hope Pharmaceuticals

Target Recruit Count: 6

Registration Number: NCT02176837

Locations: 🇺🇸
University of Virginia Medical Center, Charlottesville, Virginia, United States

Sodium Nitrite to Treat Arterial Aging

Phase 1

Completed

Conditions: Vascular Aging

Interventions: Drug: Sodium Nitrite
Drug: Placebo

First Posted Date: 2013-12-30

Last Posted Date: 2015-07-15

Lead Sponsor: University of Colorado, Boulder

Target Recruit Count: 33

Registration Number: NCT02022670

Locations: 🇺🇸
Clinical Translational Research Center, Boulder, Colorado, United States

Acute Effects of Inorganic Nitrite on Cardiovascular Hemodynamics in Heart Failure With Preserved Ejection Fraction

Phase 2

Completed

Conditions: Heart Disease
Exercise Intolerance
Heart Failure With Preserved Ejection Fraction
Pulmonary Hypertension

Interventions: Drug: Saline Placebo for Nitrite
Drug: Nitrite

First Posted Date: 2013-08-30

Last Posted Date: 2016-03-14

Lead Sponsor: Barry Borlaug

Target Recruit Count: 28

Registration Number: NCT01932606

Locations: 🇺🇸
Mayo Clinic in Rochester, Rochester, Minnesota, United States

Sodium Nitrite in Lung Transplant Patients to Minimize the Risk of Pulmonary Graft Dysfunction

Phase 2

Terminated

Conditions: Primary Graft Dysfunction

Interventions: Drug: Sodium Nitrite

First Posted Date: 2012-10-29

Last Posted Date: 2018-08-01

Lead Sponsor: Gladwin, Mark, MD

Target Recruit Count: 3

Registration Number: NCT01715883

Locations: 🇺🇸
University of pittsburgh, Pittsburgh, Pennsylvania, United States

Oral Nitrite and Nitrate in Healthy Normal Volunteer Adults

Phase 1

Completed

Conditions: Focus of Study of Healthy Adults

Interventions: Drug: 15Nitrogen(15N)-labeled sodium nitrite
Drug: 15Nitrogen(15N)-labeled sodium nitrate

First Posted Date: 2012-09-10

Last Posted Date: 2018-09-04

Lead Sponsor: Gladwin, Mark, MD

Target Recruit Count: 11

Registration Number: NCT01681836

Locations: 🇺🇸
Montefiore Hospital of UPMC, Pittsburgh, Pennsylvania, United States

Oral Nitrite in Adults With Metabolic Syndrome and Hypertension

Phase 2

Completed

Conditions: Metabolic Syndrome
Hypertension

Interventions: Drug: 14Nitrogen Sodium Nitrite

First Posted Date: 2012-09-10

Last Posted Date: 2019-04-16

Lead Sponsor: Gladwin, Mark, MD

Target Recruit Count: 20

Registration Number: NCT01681810

Locations: 🇺🇸
Montefiore Hospital of University of Pittsburgh Medical Center (UPMC), Pittsburgh, Pennsylvania, United States

Safety and Effectiveness of Intra-coronary Nitrite in Acute Myocardial Infarction

Phase 2

Completed

Conditions: Myocardial Ischemia
Cardiovascular Diseases
Myocardial Infarction
Reperfusion Injury

Interventions: Drug: Sodium Nitrite
Drug: Sodium Chloride Placebo

First Posted Date: 2012-04-25

Last Posted Date: 2017-11-29

Lead Sponsor: Barts & The London NHS Trust

Target Recruit Count: 80

Registration Number: NCT01584453

Locations: 🇬🇧
London Chest Hospital, Bethnal Green, London, United Kingdom

Inhaled Nitrite in Subjects With Pulmonary Hypertension

Phase 2

Completed

Conditions: Pulmonary Hypertension
Heart Failure, Diastolic

Interventions: Drug: Inhaled Nitrite

First Posted Date: 2011-09-09

Last Posted Date: 2019-03-28

Lead Sponsor: Schmidhofer, Mark, MD

Target Recruit Count: 48

Registration Number: NCT01431313

Locations: 🇺🇸
University of Pittsburgh, Pittsburgh, Pennsylvania, United States

Phase IIa: Safety, PK, & Tolerability of Sodium Nitrite in Patients With Peripheral Arterial Disease-SONIC

Phase 2

Completed

Conditions: Peripheral Arterial Disease

Interventions: Drug: sodium nitrite

First Posted Date: 2011-07-25

Last Posted Date: 2020-04-21

Lead Sponsor: TheraVasc Inc.

Target Recruit Count: 55

Registration Number: NCT01401517

Locations: 🇺🇸
University of Colorado Denver Health Sciences Center, Aurora, Colorado, United States
🇺🇸
Vanderbilt Heart and Vascular Institute, Nashville, Tennessee, United States
🇺🇸
Medical College of Wisconsin, Milwaukee, Wisconsin, United States

and more 7 locations

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