Metolazone
- Generic Name
- Metolazone
- Brand Names
- Mykrox, Zaroxolyn
- Drug Type
- Small Molecule
- Chemical Formula
- C16H16ClN3O3S
- CAS Number
- 17560-51-9
- Unique Ingredient Identifier
- TZ7V40X7VX
- Background
A quinazoline-sulfonamide that is considered a thiazide-like diuretic which is long-acting so useful in chronic renal failure. It also tends to lower blood pressure and increase potassium loss.
- Indication
用于治疗水肿及高血压。
- Associated Conditions
- Edema, Hypertension, Mild Hypertension, Moderate Hypertension
- Associated Therapies
- -
Efficacy and Safety of Combination Diuretic Therapy in Patients With Acute Decompensated Heart Failure and Volume Overload
- Conditions
- Interventions
- First Posted Date
- 2024-05-16
- Last Posted Date
- 2024-07-24
- Lead Sponsor
- Cairo University
- Target Recruit Count
- 110
- Registration Number
- NCT06414759
- Locations
- 🇪🇬
National Heart Institute, Giza, GZ, Egypt
Diuretic Strategies in Acute Heart Failure Patients at High Risk for Diuretic Resistance
- Conditions
- Interventions
- First Posted Date
- 2023-08-14
- Last Posted Date
- 2024-12-04
- Lead Sponsor
- Stadtspital Zürich
- Target Recruit Count
- 75
- Registration Number
- NCT05986773
- Locations
- 🇨🇭
Stadtspital Zürich, Zürich, Switzerland
Metolazone As Early Add On Therapy For Acute Decompensated Heart Failure
- Conditions
- Interventions
- First Posted Date
- 2022-12-01
- Last Posted Date
- 2022-12-01
- Lead Sponsor
- Scripps Health
- Registration Number
- NCT05633758
- Locations
- 🇺🇸
Scripps Green Torrey Pines, La Jolla, California, United States
Efficacy of Diuretics in Kidney Disease
- Conditions
- Interventions
- First Posted Date
- 2020-09-09
- Last Posted Date
- 2022-10-03
- Lead Sponsor
- Stanford University
- Target Recruit Count
- 50
- Registration Number
- NCT04542304
- Locations
- 🇺🇸
VA Palo Alto Health Care System, Palo Alto, California, United States
🇺🇸Stanford University, Palo Alto, California, United States
Ertugliflozin in Chronic Heart Failure
- Conditions
- Interventions
- First Posted Date
- 2020-06-18
- Last Posted Date
- 2024-05-03
- Lead Sponsor
- Yale University
- Target Recruit Count
- 60
- Registration Number
- NCT04438213
- Locations
- 🇺🇸
Yale School of Medicine, New Haven, Connecticut, United States
Sequential Nephron Blockade in Acute Heart Failure
- First Posted Date
- 2019-11-15
- Last Posted Date
- 2019-11-19
- Lead Sponsor
- Policlinico Casilino ASL RMB
- Target Recruit Count
- 310
- Registration Number
- NCT04163588
- Locations
- 🇮🇹
Policlinico Casilino, Rome, Lazio, Italy
Comparison of Oral or Intravenous Thiazides vs Tolvaptan in Diuretic Resistant Decompensated Heart Failure
- Conditions
- Interventions
- First Posted Date
- 2015-11-17
- Last Posted Date
- 2019-11-08
- Lead Sponsor
- Vanderbilt University
- Target Recruit Count
- 60
- Registration Number
- NCT02606253
- Locations
- 🇺🇸
Vanderbilt University Medical Center, Nashville, Tennessee, United States
A Prospective, Single-center, Randomized, Controlled, Open-label, Pilot Study to Compare the Effectiveness and Safety of DIuretics Add-On Strategy in Acute Decompensated Heart Failure Patients (DIOS II)
- Conditions
- Interventions
- First Posted Date
- 2014-01-28
- Last Posted Date
- 2016-09-07
- Lead Sponsor
- Yonsei University
- Registration Number
- NCT02047422
Drug Development Updates
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