Hydrochlorothiazide
- Generic Name
- Hydrochlorothiazide
- Brand Names
- Accuretic, Actelsar Hct, Aldactazide, Altace HCT, Atacand, Atacand Hct, Avalide, Benicar Hct, Diovan Hct, Exforge Hct, Hyzaar, Ifirmacombi, Karvezide, Lopressor Hct, Lotensin Hct, Maxzide, Micardis-hct, Olmetec Plus, Tekturna Hct, Teveten HCT, Tribenzor, Urozide, Vaseretic, Viskazide, Zestoretic, Ziac
- Drug Type
- Small Molecule
- Chemical Formula
- C7H8ClN3O4S2
- CAS Number
- 58-93-5
- Unique Ingredient Identifier
- 0J48LPH2TH
- Background
Hydrochlorothiazide is the most commonly prescribed thiazide diuretic. It is indicated to treat edema and hypertension. Hydrochlorothiazide use is common but declining in favour of angiotensin converting enzyme inhibitors. Many combination products are available containing hydrochlorothiazide and angiotensin converting enzyme inhibitors or angiotensin II rec...
- Indication
Hydrochlorothiazide is indicated alone or in combination for the management of edema associated with congestive heart failure, hepatic cirrhosis, nephrotic syndrome, acute glomerulonephritis, chronic renal failure, and corticosteroid and estrogen therapy. Hydrochlorothiazide is also indicated alone or in combination for the management of hypertension.
- Associated Conditions
- Calcium Nephrolithiasis, Cirrhosis of the Liver, Congestive Heart Failure (CHF), Diabetes Insipidus, Edema, Hypertension, Hypertension, Essential Hypertension, Hypokalemia caused by diuretics, Nephrotic Syndrome, Pre-Eclampsia, Premenstrual tension with edema, Renal tubular acidosis, Sodium retention, Stroke
- Associated Therapies
- -
Dose-Dependent Effect of Thiazide in Dent's Disease Hypercalciuria
- First Posted Date
- 2008-03-19
- Last Posted Date
- 2008-03-19
- Lead Sponsor
- Assistance Publique - Hôpitaux de Paris
- Target Recruit Count
- 10
- Registration Number
- NCT00638482
- Locations
- 🇫🇷
Centre d'investigation clinique HOPITAL GEORGE POMPIDOU, Paris, France
Candesartan Effect in Second Stage Arterial Hypertension
- Conditions
- Interventions
- First Posted Date
- 2008-02-22
- Last Posted Date
- 2010-03-23
- Lead Sponsor
- AstraZeneca
- Target Recruit Count
- 214
- Registration Number
- NCT00621153
- Locations
- 🇰🇷
Research Site, Seoul, Korea, Republic of
The Antihypertensives and Vascular, Endothelial and Cognitive Function Trial
- Conditions
- Interventions
- First Posted Date
- 2008-01-30
- Last Posted Date
- 2013-02-15
- Lead Sponsor
- University of Southern California
- Target Recruit Count
- 53
- Registration Number
- NCT00605072
- Locations
- 🇺🇸
Hebrew SeniorLife, Boston, Massachusetts, United States
🇺🇸University of Southern California, Los Angeles, California, United States
Effect of Licorice and Hydrochlorothiazide on Plasma Potassium
- Conditions
- Interventions
- First Posted Date
- 2008-01-30
- Last Posted Date
- 2009-12-15
- Lead Sponsor
- University of Oulu
- Target Recruit Count
- 10
- Registration Number
- NCT00605202
- Locations
- 🇫🇮
Oulu University Hospital, Oulu, Finland
Nephropathy In Type 2 Diabetes and Cardio-renal Events
- First Posted Date
- 2007-09-27
- Last Posted Date
- 2020-08-03
- Lead Sponsor
- University of Campania "Luigi Vanvitelli"
- Target Recruit Count
- 850
- Registration Number
- NCT00535925
- Locations
- 🇮🇹
Department of Advanced Medical and Surgical Sciences, Università della Campania "Luigi Vanvitelli", Naples, Italy, Naples, Italy
Efficacy and Safety of Valsartan and Amlodipine (± HCTZ) in Adults With Moderate, Inadequately Controlled Hypertension
- Conditions
- Interventions
- First Posted Date
- 2007-08-31
- Last Posted Date
- 2020-08-04
- Lead Sponsor
- Novartis
- Target Recruit Count
- 257
- Registration Number
- NCT00523744
- Locations
30 sites in Germany
🇩🇪Novartis Investigative Site, , Germany, Schwerin, Germany
Efficacy of Irbesartan/Hydrochlorothiazide Versus Valsartan/Hydrochlorothiazide in Mild to Moderate Hypertension
- Conditions
- Interventions
- First Posted Date
- 2007-07-12
- Last Posted Date
- 2010-07-19
- Lead Sponsor
- Sanofi
- Target Recruit Count
- 1617
- Registration Number
- NCT00500604
- Locations
- 🇻🇳
Sanofi-Aventis Administrative Office, Ho Chi Minh City, Vietnam
Nijmegen Antihypertensive Management Improvement Study
- Conditions
- First Posted Date
- 2007-04-06
- Last Posted Date
- 2012-02-14
- Lead Sponsor
- Radboud University Medical Center
- Target Recruit Count
- 120
- Registration Number
- NCT00457483
- Locations
- 🇳🇱
Nijmegen monitoring project coordinated from Nijmegen, Nijmegen, Netherlands
Efficacy and Safety of Valsartan in Combination With Amlodipine Compared to Losartan Plus Hydrochlorothiazide in Patients With Hypertension and Left Ventricular Hypertrophy
- Conditions
- Interventions
- First Posted Date
- 2007-03-13
- Last Posted Date
- 2011-05-11
- Lead Sponsor
- Novartis
- Target Recruit Count
- 90
- Registration Number
- NCT00446563
- Locations
- 🇩🇪
25 centers in Germany, Ludwigshafen, Germany
Antihypertensive Efficacy and Safety of Candesartan/HCT 32/25 mg in Comparison With Individual Components and Placebo
- Conditions
- Interventions
- First Posted Date
- 2007-02-14
- Last Posted Date
- 2010-12-16
- Lead Sponsor
- AstraZeneca
- Target Recruit Count
- 2207
- Registration Number
- NCT00434967
- Locations
- 🇸🇰
Research Site, Sahy, Slovakia
Drug Development Updates
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