Glyburide
- Generic Name
- Glyburide
- Brand Names
- Diabeta, Glucovance, Glynase, Amglidia
- Drug Type
- Small Molecule
- Chemical Formula
- C23H28ClN3O5S
- CAS Number
- 10238-21-8
- Unique Ingredient Identifier
- SX6K58TVWC
- Background
Glyburide is a second generation sulfonylurea used to treat patients with diabetes mellitus type II. It is typically given to patients who cannot be managed with the standard first line therapy, metformin. Glyburide stimulates insulin secretion through the closure of ATP-sensitive potassium channels on beta cells, raising intracellular potassium and calcium ...
- Indication
Glyburide is indicated alone or as part of combination product with metformin, as an adjunct to diet and exercise, to improve glycemic control in adults with type 2 diabetes mellitus.
- Associated Conditions
- Gestational Diabetes Mellitus (GDM), Glycemic Control, Type 2 Diabetes Mellitus
- Associated Therapies
- -
Oral Glibenclamide in Preterm Infants With Hyperglycaemia (GALOP)
- Conditions
- Interventions
- First Posted Date
- 2023-01-18
- Last Posted Date
- 2023-06-18
- Lead Sponsor
- Assistance Publique - Hôpitaux de Paris
- Target Recruit Count
- 45
- Registration Number
- NCT05687500
- Locations
- 🇫🇷
Hopital Necker - Enfants malades, Paris, France
To Evaluate the Effect of Glibenclamide in Reducing Brain Edema of TBI
- First Posted Date
- 2021-12-08
- Last Posted Date
- 2021-12-08
- Lead Sponsor
- Beijing Tiantan Hospital
- Target Recruit Count
- 76
- Registration Number
- NCT05148403
- Locations
- 🇨🇳
Beijing Tiantan Hospital Affiliated to Capital Medical University, Beijing, Beijing, China
🇨🇳Beijing Tongren Hospital, Capital Medical University, Beijing, China
Evaluate the Use of Glibenclamide on Acute aSAH
- First Posted Date
- 2021-11-30
- Last Posted Date
- 2022-02-14
- Lead Sponsor
- Beijing Tiantan Hospital
- Target Recruit Count
- 110
- Registration Number
- NCT05137678
- Locations
- 🇨🇳
Beijing Tiantan Hospital Affiliated to Capital Medical University, Beijing, Beijing, China
The Hemodynamic Effects of PACAP38 After Glibenclamide Administration in Healthy Volunteers
- First Posted Date
- 2021-07-14
- Last Posted Date
- 2021-07-14
- Lead Sponsor
- Danish Headache Center
- Target Recruit Count
- 22
- Registration Number
- NCT04960657
- Locations
- 🇩🇰
Danish Headache Center, Copenhagen, Capital Region, Denmark
The Hemodynamic Effects of CGRP After Glibenclamide Administration in Healthy Volunteers
- Conditions
- Interventions
- First Posted Date
- 2020-01-18
- Last Posted Date
- 2020-09-09
- Lead Sponsor
- Danish Headache Center
- Target Recruit Count
- 20
- Registration Number
- NCT04231617
- Locations
- 🇩🇰
Mohammad Al-Mahdi Al-Karagholi, København S, Danmark, Denmark
🇩🇰Danish headache center, Glostrup, Copenhagen, Denmark
Study to Evaluate the Effect of IW-3718 on the Pharmacokinetics of Oral Contraceptive, Levothyroxine, Glyburide, and Digoxin in Healthy Adult Volunteers
- Conditions
- Interventions
- First Posted Date
- 2019-02-27
- Last Posted Date
- 2019-07-29
- Lead Sponsor
- Ironwood Pharmaceuticals, Inc.
- Target Recruit Count
- 87
- Registration Number
- NCT03856970
- Locations
- 🇺🇸
PPD, Austin, Texas, United States
Glibenclamide in Aneurysmatic Subarachnoid Hemorrhage
- First Posted Date
- 2018-06-26
- Last Posted Date
- 2018-06-26
- Lead Sponsor
- University of Sao Paulo General Hospital
- Target Recruit Count
- 50
- Registration Number
- NCT03569540
- Locations
- 🇧🇷
Hospital das Clínicas da Faculdade de Medicina de São Paulo, São Paulo, SP, Brazil
Safety and Efficacy of Glibenclamide Combined With Rt-PA in Acute Cerebral Embolism
- First Posted Date
- 2017-09-15
- Last Posted Date
- 2023-06-12
- Lead Sponsor
- Nanfang Hospital, Southern Medical University
- Target Recruit Count
- 306
- Registration Number
- NCT03284463
- Locations
- 🇨🇳
Huadu District People's Hospital of Guangzhou, Guangzhou, Guangdong, China
🇨🇳Maoming People's Hospital, Maoming, Guangdong, China
🇨🇳Nanfang Hospital of Southern Medical University, Guangzhou, Guangdong, China
Failure Rate of GLyburide And Metformin Among Gestational Diabetics
- Conditions
- Interventions
Metabolic Analysis for Treatment Choice in Gestational Diabetes Mellitus
- Conditions
- Interventions
- First Posted Date
- 2017-01-24
- Last Posted Date
- 2024-11-28
- Lead Sponsor
- Maisa N. Feghali, MD
- Target Recruit Count
- 54
- Registration Number
- NCT03029702
- Locations
- 🇺🇸
Magee Womens Hospital of UPMC, Pittsburgh, Pennsylvania, United States
Drug Development Updates
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