Calcitonin gene-related peptide
- Generic Name
- Calcitonin gene-related peptide
- Drug Type
- Biotech
- CAS Number
- 83652-28-2
- Unique Ingredient Identifier
- JHB2QIZ69Z
- Background
A 37-amino acid peptide derived from the calcitonin gene. It occurs as a result of alternative processing of mRNA from the calcitonin gene. The neuropeptide is widely distributed in the brain, gut, perivascular nerves, and other tissue. The peptide produces multiple biological effects and has both circulatory and neurotransmitter modes of action. In particular, it is a potent endogenous vasodilator.
As a potential drug, it has demonstrated in preclinical studies a profile that could make it an ideal anti-asthmatic drug candidate with bronchodilatory, bronchoprotecting and anti-inflammatory properties.
- Indication
Investigated for use/treatment in myocardial infarction, heart disease, and asthma.
NDPH Biomarker Study in Children and Adolescents
- First Posted Date
- 2023-08-30
- Last Posted Date
- 2025-04-16
- Lead Sponsor
- Duke University
- Target Recruit Count
- 30
- Registration Number
- NCT06018025
- Locations
- 🇺🇸
Duke University Health System, Durham, North Carolina, United States
Hypersensitivity to CGRP as a Predictive Biomarker of Migraine Prevention With Erenumab
- First Posted Date
- 2020-10-19
- Last Posted Date
- 2022-10-24
- Lead Sponsor
- Danish Headache Center
- Target Recruit Count
- 400
- Registration Number
- NCT04592952
- Locations
- 🇩🇰
Danish Headache Center, Copenhagen, Glostrup, Denmark
The Effect of Anti-calcitonin Gene-related Peptide (CGRP) Receptor Antibodies on the Headache Inducing Properties of CGRP and Cilostazol in Migraine Patients
- Conditions
- Migraine Without AuraMigraine With AuraMigraine
- Interventions
- First Posted Date
- 2020-07-01
- Last Posted Date
- 2020-10-08
- Lead Sponsor
- Danish Headache Center
- Target Recruit Count
- 72
- Registration Number
- NCT04452929
- Locations
- 🇩🇰
Danish Headache Center, Glostrup, Denmark
The Hemodynamic Effects of CGRP After Glibenclamide Administration in Healthy Volunteers
- Conditions
- Hemodynamics of Cranial ArteriesHeadacheCerebral Blood Flow
- Interventions
- First Posted Date
- 2020-01-18
- Last Posted Date
- 2020-09-09
- Lead Sponsor
- Danish Headache Center
- Target Recruit Count
- 20
- Registration Number
- NCT04231617
- Locations
- 🇩🇰
Mohammad Al-Mahdi Al-Karagholi, København S, Danmark, Denmark
🇩🇰Danish headache center, Glostrup, Copenhagen, Denmark
Clinical Characteristics and Pathophysiology of Post-Traumatic Headache
- Conditions
- Concussion, MildPost-Traumatic Headache
- Interventions
- Drug: Placebo
- First Posted Date
- 2019-01-02
- Last Posted Date
- 2020-01-29
- Lead Sponsor
- Danish Headache Center
- Target Recruit Count
- 200
- Registration Number
- NCT03791515
- Locations
- 🇩🇰
Danish Headache Center, Glostrup, Denmark
The Effect of Sumatriptan and Placebo on CGRP Induced Headache
- Conditions
- Migraine
- Interventions
- First Posted Date
- 2018-05-31
- Last Posted Date
- 2019-09-12
- Lead Sponsor
- Danish Headache Center
- Target Recruit Count
- 30
- Registration Number
- NCT03542357
- Locations
- 🇩🇰
Rigshospitalet Glostrup, Glostrup, Denmark
CGRP-induced Migraine Attacks in Patients Who Have Tried Anti-CGRP Monoclonal Antibody Treatment
- First Posted Date
- 2018-03-29
- Last Posted Date
- 2018-03-29
- Lead Sponsor
- Danish Headache Center
- Target Recruit Count
- 40
- Registration Number
- NCT03481400
- Locations
- 🇩🇰
Danish Headache Center, Rigshospitalet Glostrup, Copenhagen, Glostrup, Denmark
Pharmacologically Triggered Migraine Without Aura and Neuroimaging
- Conditions
- Migraine With Aura
- Interventions
- First Posted Date
- 2017-05-08
- Last Posted Date
- 2019-02-15
- Lead Sponsor
- Danish Headache Center
- Target Recruit Count
- 36
- Registration Number
- NCT03143465
- Locations
- 🇩🇰
Danish Headache Center, University Hospital, Glostrup, Denmark
CGRP Induced Migraine Attacks in Patients With High and Low Genetic Load
- First Posted Date
- 2013-08-16
- Last Posted Date
- 2022-08-02
- Lead Sponsor
- Danish Headache Center
- Target Recruit Count
- 40
- Registration Number
- NCT01924052
Calcitonin Gene-related Peptide in Familial Hemiplegic Migraine (FHM) and Migraine With Aura (MA)
- Conditions
- Familial Hemiplegic MigraineMigraine With AuraHealthy
- Interventions
- First Posted Date
- 2008-06-02
- Last Posted Date
- 2009-08-03
- Lead Sponsor
- Danish Headache Center
- Target Recruit Count
- 30
- Registration Number
- NCT00687947
- Locations
- 🇩🇰
Danish Headache Center, University of Copenhagen, Faculty of Health Sciences, Department of Neurology, Glostrup Hospital, Glostrup, Copenhagen, Denmark
Drug Development Updates
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