Irinotecan is an antineoplastic enzyme inhibitor primarily used in the treatment of colorectal cancer. It is a derivative of camptothecin that inhibits the action of topoisomerase I. Irinotecan prevents religation of the DNA strand by binding to topoisomerase I-DNA complex, and causes double-strand DNA breakage and cell death. It is a derivative of camptothecin. Irinotecan was approved for the treatment of advanced pancreatic cancer in October, 2015 (irinotecan liposome injection, trade name Onivyde).
For the treatment of metastatic colorectal cancer (first-line therapy when administered with 5-fluorouracil and leucovorin). Also used in combination with cisplatin for the treatment of extensive small cell lung cancer. Irinotecan is currently under investigation for the treatment of metastatic or recurrent cervical cancer. Also used in combination with fluorouracil and leucovorin for the treatment of patients with metastatic adenocarcinoma of the pancreas after disease progression following gemcitabine-based therapy.
Hirosahi University Graduate School of Medicine, Hirosaki, Aomori, Japan
Fukuyama City Hospital, Fukuyama, Hiroshima, Japan
Asahikawa Medical College Hospital, Asahikawa, Hokkaido, Japan
Hopital Ambroise Pare, Boulogne-Billancourt, France
Hopital Du Bocage, Dijon, France
Centre Hospitalier Departemental, La Roche Sur Yon, France
UCSF Helen Diller Family Comprehensive Cancer Center, San Francisco, California, United States
Yonsei Cancer Center at Yonsei University Medical Center, Seoul, Korea, Republic of
Air Forces Military Hospital, Dep of Medical Oncology, Athens, Greece
IASO" General Hospital of Athens, 1st Dep of Medical Oncology, Athens, Greece
Memorial Sloan-Kettering Cancer Center, New York, New York, United States
Duke University Health System, Durham, North Carolina, United States
Usc/Norris Comprehensive Cancer Center Hospital, Los Angeles, California, United States
Usc/Norris Comprehensive Cancer Center, Los Angeles, California, United States
Washington University, Saint Louis, Missouri, United States
Memorial Sloan Kettering Cancer Center, New York, New York, United States
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