levcromakalim

Generic Name: levcromakalim

Clinical Trials

Effect of Levcromakalim in Individuals With Migraine Pretreated With Erenumab

Not Applicable

Completed

Conditions: Migraine Without Aura

Interventions: Other: Placebo
Drug: Levcromakalim

First Posted Date: 2023-06-05

Last Posted Date: 2023-10-24

Lead Sponsor: Danish Headache Center

Target Recruit Count: 16

Registration Number: NCT05889442

Locations: 🇩🇰
Danish Headache Center, Copenhagen, Denmark

The Involvement of ATP Sensitive Potassium Channel in Migraine Aura and Migraine Pain.

Not Applicable

Recruiting

Conditions: Headache
Migraine Without Aura
Migraine With Aura

Interventions: Drug: Levcromakalim

First Posted Date: 2022-10-04

Last Posted Date: 2023-03-22

Lead Sponsor: Danish Headache Center

Target Recruit Count: 20

Registration Number: NCT05565001

Locations: 🇩🇰
Danish headache center, Copenhagen, Glostrup, Denmark

Hypersensitivity to Opening of ATP-Sensitive Potassium Channels in Post-Traumatic Headache

Not Applicable

Completed

Conditions: Post-Traumatic Headache

Interventions: Drug: Placebo
Drug: Levcromakalim

First Posted Date: 2022-02-17

Last Posted Date: 2022-07-08

Lead Sponsor: Danish Headache Center

Target Recruit Count: 21

Registration Number: NCT05243953

Locations: 🇩🇰
Danish Headache Center, Copenhagen, Denmark

Effect of Sumatriptan on Levcromakalim-Induced Symptoms in Individuals With Migraine

Not Applicable

Completed

Conditions: Migraine Without Aura
Headache

Interventions: Drug: Levcromakalim
Drug: Saline
Drug: Sumatriptan

First Posted Date: 2022-01-27

Last Posted Date: 2025-01-22

Lead Sponsor: Danish Headache Center

Target Recruit Count: 24

Registration Number: NCT05211050

Locations: 🇩🇰
Danish Headache Centre, Glostrup, Zealand, Denmark

The Effects of Levcromakalim in Patients With Cluster Headache

Not Applicable

Completed

Conditions: Cluster Headache

Interventions: Drug: Levcromakalim
Drug: Saline

First Posted Date: 2021-10-26

Last Posted Date: 2023-06-28

Lead Sponsor: Danish Headache Center

Target Recruit Count: 41

Registration Number: NCT05093582

Locations: 🇩🇰
Danish Headache Center, Glostrup, Copenhagen, Denmark

Migraine Inducing Effect of Levcromakalim in Patients With Migraine With Aura

Not Applicable

Completed

Conditions: Headache, Migraine
Aura

Interventions: Drug: Saline
Drug: Levcromakalim

First Posted Date: 2021-05-27

Last Posted Date: 2023-05-17

Lead Sponsor: Danish Headache Center

Target Recruit Count: 35

Registration Number: NCT04905654

Locations: 🇩🇰
Danish Headache Center, Glostrup, Copenhagen, Denmark

Effect of Ivabradine on Levcromakalim-Induced Symptoms in Individuals With Migraine Without Aura (ILIM)

Not Applicable

Recruiting

Conditions: Headache
Migraine Without Aura

Interventions: Drug: Levcromakalim
Drug: Placebo
Drug: Ivabradine

First Posted Date: 2021-04-21

Last Posted Date: 2024-03-25

Lead Sponsor: Danish Headache Center

Target Recruit Count: 30

Registration Number: NCT04853797

Locations: 🇩🇰
Danish Headache Centre, Rigshospitalet-Glostrup, Glostrup, Zealand, Denmark
🇩🇰
Danish Headache Center, Glostrup, Denmark

Headache Inducing Effect of Levcromakalim in Migraine With Aura Patients

Not Applicable

Completed

Conditions: Headache
Migraine
Aura

Interventions: Drug: Levcromakalim
Drug: Saline

First Posted Date: 2019-07-09

Last Posted Date: 2020-03-02

Lead Sponsor: Danish Headache Center

Target Recruit Count: 17

Registration Number: NCT04012047

Locations: 🇩🇰
Danish headache center, Glostrup, Denmark

The Hemodynamics Effect of Glibenclamide on Levcromakalim Assessed by High Resolution Magnetic Resonance Angiography (MRA) Technique in a Randomized Double-blind Cross-over Placebo-controlled Study With Healthy Volunteers

Not Applicable

Conditions: Hemodynamics of Cranial Arteries
Headache
Cerebral Blood Flow

Interventions: Drug: Levcromakalim
Drug: Saline

First Posted Date: 2019-03-22

Last Posted Date: 2022-07-07

Lead Sponsor: Danish Headache Center

Target Recruit Count: 15

Registration Number: NCT03886922

Locations: 🇩🇰
Mohammad Al-Mahdi Al-Karagholi, København S, Danmark, Denmark
🇩🇰
Danish headache center, Glostrup, Copenhagen, Denmark

Peripheral Nociceptive Effects of Levcromakalim

Not Applicable

Completed

Conditions: Levcromakalim
Pain

Interventions: Drug: Levcromakalim
Drug: Saline

First Posted Date: 2018-10-31

Last Posted Date: 2019-01-23

Lead Sponsor: Danish Headache Center

Target Recruit Count: 20

Registration Number: NCT03726242

Locations: 🇩🇰
Danish headache center, Glostrup, Copenhagen, Denmark

Drug Development Updates

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