Oxytocin
- Generic Name
- Oxytocin
- Brand Names
- Pitocin
- Drug Type
- Biotech
- Chemical Formula
- -
- CAS Number
- 50-56-6
- Unique Ingredient Identifier
- 1JQS135EYN
- Background
Sir Henry H. Dale first identified oxytocin and its uterine contractile properties in 1906. Like all other neurohypophysial hormones, oxytocin is composed of nine amino acids with a disulfide bridge between the Cys 1 and 6 residues. In the mid-1950s, synthetic oxytocin was successfully synthesized by a biochemist named Vincent du Vigneaud; he was later recog...
- Indication
Administration of exogenous oxytocin is indicated in the antepartum period to initiate or improve uterine contractions for vaginal delivery in situations where there is fetal or maternal concern. For example, It may be used to induce labor in cases of Rh sensitization, maternal diabetes, preeclampsia at or near term, and when delivery is indicated due to pre...
- Associated Conditions
- Incomplete Abortion, Inevitable abortion, Postpartum Bleeding
- Associated Therapies
- Reinforcement of labor
The Role of Oxytocin in Regulating Blood Glucose
- Conditions
- Interventions
- First Posted Date
- 2024-03-27
- Last Posted Date
- 2024-04-04
- Lead Sponsor
- University Hospital, Gentofte, Copenhagen
- Target Recruit Count
- 20
- Registration Number
- NCT06334172
- Locations
- 🇩🇰
Center for Clinical Metabolic Research, Gentofte Hospital, Hellerup, Capital Region, Denmark
Misoprostol Versus Oxytocin Infusion On Reducing Blood Loss During Abdominal Myomectomy
- First Posted Date
- 2024-03-22
- Last Posted Date
- 2024-03-22
- Lead Sponsor
- Cairo University
- Target Recruit Count
- 56
- Registration Number
- NCT06325501
- Locations
- 🇪🇬
faculty of medicine, Kasr el ainy hospital, Cairo university, Cairo, Egypt
Effect of Ephedrine, Phenylepinephrine, and Norepinephrine on Myometrial Contractility in Pregnant People With Type II and Gestational Diabetes During Cesarean Section: An In-vitro Study
- Conditions
- Interventions
- First Posted Date
- 2024-02-29
- Last Posted Date
- 2024-04-12
- Target Recruit Count
- 24
- Registration Number
- NCT06285396
- Locations
- 🇨🇦
Mount Sinai Hospital, Toronto, Ontario, Canada
Comparing the Dose-response Profiles of Uterotonics After Initial Carbetocin Administration - an Ex-vivo Study in Desensitized Human Myometrium
- Conditions
- Interventions
- First Posted Date
- 2024-02-29
- Last Posted Date
- 2024-04-12
- Target Recruit Count
- 32
- Registration Number
- NCT06285409
- Locations
- 🇨🇦
Mount Sinai Hospital, Toronto, Ontario, Canada
Different Medications to Induce Labor
- First Posted Date
- 2024-02-14
- Last Posted Date
- 2024-08-05
- Lead Sponsor
- Icahn School of Medicine at Mount Sinai
- Target Recruit Count
- 300
- Registration Number
- NCT06259097
- Locations
- 🇺🇸
Mount Sinai Hospital, New York, New York, United States
The Role of Oxytocin-receptor Signalling in Physiological Regulation of Eating Behaviour in Individuals With Obesity
- First Posted Date
- 2024-01-03
- Last Posted Date
- 2024-05-14
- Lead Sponsor
- University Hospital, Gentofte, Copenhagen
- Target Recruit Count
- 24
- Registration Number
- NCT06189001
- Locations
- 🇩🇰
Center for Clinical Metabolisk Research, Hellerup, Denmark
Time of Oxytocin Initiation at 2nd Stage of Labor and Adverse Outcomes
- Conditions
- Interventions
- First Posted Date
- 2023-12-26
- Last Posted Date
- 2023-12-26
- Lead Sponsor
- Rambam Health Care Campus
- Target Recruit Count
- 120
- Registration Number
- NCT06181396
- Locations
- 🇮🇱
Rambam medical health campus, Haifa, Israel
Comparing Intramyometrial Tranexamic Acid and Oxytocin for Blood Loss in Cesarean Section
- Conditions
- Interventions
- First Posted Date
- 2023-08-24
- Last Posted Date
- 2024-04-09
- Lead Sponsor
- Cairo University
- Target Recruit Count
- 150
- Registration Number
- NCT06010368
- Locations
- 🇪🇬
Suez Canal University, Ismailia, Egypt
Defining a PK and PD Model for Peripheral Analgesia After IV Oxytocin
- First Posted Date
- 2023-07-03
- Last Posted Date
- 2024-08-05
- Lead Sponsor
- Wake Forest University Health Sciences
- Target Recruit Count
- 24
- Registration Number
- NCT05929339
- Locations
- 🇺🇸
Wake Forest Baptist Health, Winston-Salem, North Carolina, United States
Methods Decreasing Bleeding in Open Myomectomy
- Conditions
- Interventions
- First Posted Date
- 2023-04-10
- Last Posted Date
- 2023-04-10
- Lead Sponsor
- Cairo University
- Target Recruit Count
- 105
- Registration Number
- NCT05806307
- Locations
- 🇪🇬
faculty of medicine, Kasr el ainy hospital, Cairo university, Cairo, Egypt
Drug Development Updates
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