Oxytocin

Generic Name
Oxytocin
Brand Names
Pitocin
Drug Type
Biotech
Chemical Formula
-
CAS Number
50-56-6
Unique Ingredient Identifier
1JQS135EYN
Background

Sir Henry H. Dale first identified oxytocin and its uterine contractile properties in 1906. Like all other neurohypophysial hormones, oxytocin is composed of nine amino acids with a disulfide bridge between the Cys 1 and 6 residues. In the mid-1950s, synthetic oxytocin was successfully synthesized by a biochemist named Vincent du Vigneaud; he was later recog...

Indication

Administration of exogenous oxytocin is indicated in the antepartum period to initiate or improve uterine contractions for vaginal delivery in situations where there is fetal or maternal concern. For example, It may be used to induce labor in cases of Rh sensitization, maternal diabetes, preeclampsia at or near term, and when delivery is indicated due to pre...

Associated Conditions
Incomplete Abortion, Inevitable abortion, Postpartum Bleeding
Associated Therapies
Reinforcement of labor

Low-Dose Versus High-Dose Oxytocin Dosing for Induction and Augmentation of Labor

Phase 4
Recruiting
Conditions
Interventions
First Posted Date
2023-03-24
Last Posted Date
2024-05-08
Lead Sponsor
The University of Texas Medical Branch, Galveston
Target Recruit Count
170
Registration Number
NCT05782816
Locations
🇺🇸

University of Texas Medical Branch, Galveston, Texas, United States

Carbetocin Compared To Oxytocin During Cesarean Delivery

Not yet recruiting
Conditions
Interventions
First Posted Date
2023-03-07
Last Posted Date
2023-03-07
Lead Sponsor
Assiut University
Target Recruit Count
260
Registration Number
NCT05758012
Locations
🇰🇼

Munistery of Health Kuwait, Kuwait, Kuwait

Role of Local Skin Incision Infiltration by Oxytocin On Wound Healing

Not Applicable
Recruiting
Conditions
Interventions
First Posted Date
2023-02-27
Last Posted Date
2023-10-17
Lead Sponsor
Egymedicalpedia
Target Recruit Count
120
Registration Number
NCT05745935
Locations
🇪🇬

Al Amerya hospital, Cairo, Egypt

Comparison Of The Effects Of Carbetocin And Oxytocin In C-Sectıon

First Posted Date
2023-02-24
Last Posted Date
2023-03-07
Lead Sponsor
Ege University
Target Recruit Count
200
Registration Number
NCT05742854
Locations
🇹🇷

EÜTF, Bornova, İ̇zmi̇r, Turkey

Effects of Vaginal Oxytocin Gel on Vaginal Cytologic Parameters in Postmenopausal Woman

First Posted Date
2022-11-28
Last Posted Date
2023-08-31
Lead Sponsor
Rajavithi Hospital
Target Recruit Count
6
Registration Number
NCT05627791
Locations
🇹🇭

Rajavithi Hospital, Bangkok, Thailand

Balloon + Oxytocin Versus Oral Misoprostol to Induce Labor in Case of PROM (RUBAPRO2)

First Posted Date
2022-10-06
Last Posted Date
2023-01-25
Lead Sponsor
University Hospital, Clermont-Ferrand
Target Recruit Count
520
Registration Number
NCT05568745
Locations
🇫🇷

CHU de Saint Etienne, Saint-Étienne, France

🇫🇷

CHU de Toulouse, Toulouse, France

🇫🇷

CHU de Clermont-Ferrand, Clermont-Ferrand, France

and more 2 locations

Sublingual Misoprostol in Reduction of Caesarean Blood Loss

Not Applicable
Recruiting
Conditions
Interventions
First Posted Date
2022-09-08
Last Posted Date
2023-04-12
Lead Sponsor
OZORI EBIOGBO STANLEY
Target Recruit Count
152
Registration Number
NCT05532215
Locations
🇳🇬

Federal Medical Centre Yenagoa, Yenagoa, Bayelsa, Nigeria

In Vitro Evaluation of Spontaneous and Oxytocin-induced Contractility of Pregnant Human Myometrium During Exposure to Dexmedetomidine

Not Applicable
Recruiting
Conditions
Interventions
First Posted Date
2022-08-23
Last Posted Date
2024-02-26
Lead Sponsor
Samuel Lunenfeld Research Institute, Mount Sinai Hospital
Target Recruit Count
28
Registration Number
NCT05511415
Locations
🇨🇦

Mount Sinai Hospital, Toronto, Ontario, Canada

Carbetocin Versus Oxytocin for Prophylaxis Against Atonic Primary Post-partum Hemorrhage

First Posted Date
2022-07-29
Last Posted Date
2022-08-02
Lead Sponsor
Sohag University
Target Recruit Count
80
Registration Number
NCT05479357
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