Methotrexate

Generic Name
Methotrexate
Brand Names
Metoject, Nordimet, Otrexup, Rasuvo, Reditrex, Trexall, Xatmep, Jylamvo
Drug Type
Small Molecule
Chemical Formula
C20H22N8O5
CAS Number
59-05-2
Unique Ingredient Identifier
YL5FZ2Y5U1
Background

Methotrexate is a folate derivative that inhibits several enzymes responsible for nucleotide synthesis. This inhibition leads to suppression of inflammation as well as prevention of cell division. Because of these effects, methotrexate is often used to treat inflammation caused by arthritis or to control cell division in neoplastic diseases such as breast ca...

Indication

Methotrexate oral solution is indicated for pediatric acute lymphoblastic leukemia and pediatric polyarticular juvenile idiopathic arthritis. Methotrexate injections for subcutaneous use are indicated for severe active rheumatoid arthritis, polyarticular juvenile idiopathic arthritis and severe, recalcitrant, disabling psoriasis.
...

Associated Conditions
Acute Lymphoblastic Leukemia (ALL), Acute Promyelocytic Leukemia, Bladder Cancer, Breast Cancer, Central Nervous System Lymphoma, Crohn's Disease (CD), Dermatomyositis (DM), Extrauterine Pregnancy, Gestational Trophoblastic Neoplasia, Graft-versus-host Disease (GVHD), Meningeal leukemia, Multiple Sclerosis, Mycosis Fungoides (MF), Non-Hodgkin's Lymphoma (NHL), Non-Hodgkin's Lymphoma, Relapsed, Osteosarcoma, Polyarticular Juvenile Idiopathic Arthritis, Polymyositis, Rheumatoid Arthritis, Soft Tissue Sarcoma, Squamous Cell Carcinoma of the Head and Neck (SCCHN), Systemic Lupus Erythematosus, Uveitis, Nonleukemic meningeal cancer, Refractory Non-Hodgkin's lymphoma, Refractory Takayasu arteritis, Severe Psoriasis
Associated Therapies
Medically induced abortion
Clinical Trials
Related News

Mini-dose MTX Plus Standard-dose Steroid for the Initial Treatment of Acute GVHD

Phase 3
Recruiting
Conditions
Acute Graft Versus Host Disease
Interventions
Drug: Corticosteroid
Drug: MTX
First Posted Date
2023-06-27
Last Posted Date
2023-10-10
Lead Sponsor
Peking University People's Hospital
Target Recruit Count
218
Registration Number
NCT05921305
Locations
🇨🇳

Nanfang Hospital, Nanfang Medical University, Guangzhou, Guangdong, China

🇨🇳

Peking University Institute of Hematology,, Beijing, Beijing, China

Assessment of the Efficacy of Letrozole in the Treatment of Ectopic Pregnancy

Phase 1
Active, not recruiting
Conditions
Ectopic Pregnancy
Interventions
Drug: methotrexate
Drug: Letrozole
First Posted Date
2023-06-26
Last Posted Date
2024-03-26
Lead Sponsor
Tehran University of Medical Sciences
Target Recruit Count
150
Registration Number
NCT05918718
Locations
🇮🇷

Imam Khomeini Hospital Complex, Tehran, Iran, Islamic Republic of

Zanubrutinib Combined With Rituximab and Chemotherapy for Newly-Diagnosed PCNSLBCL Patients Intolerant to HSCT

First Posted Date
2023-06-09
Last Posted Date
2023-09-05
Lead Sponsor
Ruijin Hospital
Target Recruit Count
29
Registration Number
NCT05896007
Locations
🇨🇳

Ruijin Hospital, Shanghai, Shanghai, China

TINI 2: Total Therapy for Infants With Acute Lymphoblastic Leukemia II

First Posted Date
2023-05-08
Last Posted Date
2024-11-25
Lead Sponsor
Tanja Andrea Gruber
Target Recruit Count
90
Registration Number
NCT05848687
Locations
🇺🇸

Phoenix Children's Hospital, Phoenix, Arizona, United States

🇺🇸

Arkansas Children's Hospital, Little Rock, Arkansas, United States

🇺🇸

Children's Hospital Los Angeles, Los Angeles, California, United States

and more 22 locations

Mind and Skin - the Neurocutaneous Axis in Atopic Eczema

First Posted Date
2023-03-30
Last Posted Date
2024-05-03
Lead Sponsor
King's College London
Target Recruit Count
90
Registration Number
NCT05790330
Locations
🇬🇧

Unit for Paediatric and Population-based Dermatology Research, London, United Kingdom

A Study of Revumenib in Combination With Chemotherapy for Patients Diagnosed With Relapsed or Refractory Leukemia

Phase 2
Recruiting
Conditions
Recurrent Acute Myeloid Leukemia Due to Lineage Switch From Mixed Phenotype Acute Leukemia
Refractory Acute Myeloid Leukemia Due to Lineage Switch From Mixed Phenotype Acute Leukemia
Recurrent Mixed Phenotype Acute Leukemia
Recurrent Acute Leukemia of Ambiguous Lineage
Recurrent Acute Myeloid Leukemia Due to Lineage Switch From B Acute Lymphoblastic Leukemia, KMT2A-Rearranged
Refractory Acute Myeloid Leukemia Due to Lineage Switch From B Acute Lymphoblastic Leukemia, KMT2A-Rearranged
Recurrent Acute Lymphoblastic Leukemia
Recurrent Acute Myeloid Leukemia Due to Lineage Switch From Acute Leukemia of Ambiguous Lineage
Refractory Acute Leukemia of Ambiguous Lineage
Refractory Acute Lymphoblastic Leukemia
Interventions
Procedure: Biospecimen Collection
Procedure: Bone Marrow Aspiration
Drug: Cytarabine
Drug: Calaspargase Pegol
Procedure: Echocardiography
Drug: Fludarabine Phosphate
Drug: Hydrocortisone Sodium Succinate
Procedure: Lumbar Puncture
Drug: Methotrexate
Procedure: Multigated Acquisition Scan
Drug: Prednisolone
Drug: Prednisone
Drug: Revumenib
Drug: Vincristine Sulfate
First Posted Date
2023-03-09
Last Posted Date
2024-12-04
Lead Sponsor
Children's Oncology Group
Target Recruit Count
78
Registration Number
NCT05761171
Locations
🇺🇸

Kaiser Permanente Downey Medical Center, Downey, California, United States

🇺🇸

Renown Regional Medical Center, Reno, Nevada, United States

🇺🇸

Memorial Sloan Kettering Cancer Center, New York, New York, United States

and more 62 locations

Study to Investigate Outcome of Individualized Treatment in Patients With Metastatic Colorectal Cancer

First Posted Date
2023-02-13
Last Posted Date
2023-02-21
Lead Sponsor
Oslo University Hospital
Target Recruit Count
40
Registration Number
NCT05725200
Locations
🇳🇴

Oslo University Hospital, Oslo, Norway

Selinexor in Combination With MTX+Ritu to Treat R/R CNSL

First Posted Date
2023-01-26
Last Posted Date
2024-06-17
Lead Sponsor
Tong Chen, MD
Target Recruit Count
30
Registration Number
NCT05698147
Locations
🇨🇳

Oncology Department of The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China

🇨🇳

Beijing Tiantan Hospital, Capital Medical University, Beijing, Beijing, China

🇨🇳

The First Affiliated Hospital Of Fujian Medical University, Fuzhou, Fujian, China

and more 2 locations

A Study to Test the Addition of the Drug Cabozantinib to Chemotherapy in Patients With Newly Diagnosed Osteosarcoma

First Posted Date
2023-01-20
Last Posted Date
2024-12-13
Lead Sponsor
National Cancer Institute (NCI)
Target Recruit Count
1122
Registration Number
NCT05691478
Locations
🇺🇸

Newark Beth Israel Medical Center, Newark, New Jersey, United States

🇺🇸

State University of New York Upstate Medical University, Syracuse, New York, United States

🇺🇸

Alfred I duPont Hospital for Children, Wilmington, Delaware, United States

and more 89 locations

Roflumilast Versus Methotrexate in Psoriasis

Phase 2
Completed
Conditions
Psoriasis
Interventions
Drug: Roflumilast
Drug: Methotrexate
First Posted Date
2023-01-13
Last Posted Date
2023-05-16
Lead Sponsor
Cairo University
Target Recruit Count
30
Registration Number
NCT05684744
Locations
🇪🇬

Cairo University, Cairo, Egypt

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