Remifentanil

Generic Name: Remifentanil

Brand Names: Ultiva

Drug Type: Small Molecule

Chemical Formula: C_₂₀H_₂₈N_₂O_₅

CAS Number: 132875-61-7

Unique Ingredient Identifier: P10582JYYK

Background: Remifentanil (marketed by Abbott as Ultiva) is a potent ultra short-acting synthetic opioid given to patients during surgery for pain relief and adjunctive to an anaesthetic. Remifentanil is a specific mu-type-opioid receptor agonist which means it reduces sympathetic nervous system tone, and causes respiratory depression and analgesia.

Indication: For use during the induction and maintenance of general anesthesia.

Associated Conditions: -

Associated Therapies: Immediate postoperative analgesia therapy, Induction and Maintenance of General Anesthesia, Monitored anesthesia care sedation

Clinical Trials

Methadone vs Magnesium in Spinal Fusion

Phase 2

Completed

Conditions: Idiopathic Scoliosis

Interventions: Drug: Methadone hydrochloride
Drug: Remifentanil
Drug: Magnesium Sulfate

First Posted Date: 2013-02-20

Last Posted Date: 2018-02-08

Lead Sponsor: Nationwide Children's Hospital

Target Recruit Count: 63

Registration Number: NCT01795495

Locations: 🇺🇸
Nationwide Children's Hospital, Columbus, Ohio, United States

Dexmedetomidine vs. Remifentanil for Pre-eclampsia During Caesarean Delivery

Phase 2

Completed

Conditions: Severe Pre-eclampsia
Pregnancy

Interventions: Drug: Dexmedetomidine
Drug: Remifentanil

First Posted Date: 2013-01-11

Last Posted Date: 2017-01-23

Lead Sponsor: Mansoura University

Target Recruit Count: 50

Registration Number: NCT01766089

Locations: 🇪🇬
Mansoura University Hospitals, Mansoura, DK, Egypt

Effect of Higher Doses of Remifentanil on Postoperative Pain in Patients Undergoing Thyroidectomy

Phase 4

Conditions: Nodular Goiter

Interventions: Drug: Remifentanil

First Posted Date: 2013-01-04

Last Posted Date: 2013-01-04

Lead Sponsor: Central South University

Target Recruit Count: 60

Registration Number: NCT01761149

Locations: 🇨🇳
Department of Anesthesiology, The Second Xiangya Hospital, Changsha, Hunan, China

A Comparison of Esmolol and Remifentanil to Reduce Blood Loss

Phase 4

Conditions: Deviation Septum Nasal

Interventions: Drug: Remifentanil
Drug: Esmolol

First Posted Date: 2012-12-19

Last Posted Date: 2012-12-19

Lead Sponsor: Diskapi Teaching and Research Hospital

Target Recruit Count: 60

Registration Number: NCT01752959

Locations: 🇹🇷
Diskapi Yildirim Beyazit Training and Research Hospital, Ankara, Turkey

Remifentanil Versus Propofol for TCI Sedation of Patients Undergoing Gastrointestinal Endoscopic Procedures

Phase 4

Terminated

Conditions: Pain

Interventions: Drug: Propofol
Drug: Remifentanil

First Posted Date: 2012-12-11

Last Posted Date: 2012-12-11

Lead Sponsor: Fundación Universitaria de Ciencias de la Salud

Target Recruit Count: 69

Registration Number: NCT01746641

Locations: 🇨🇴
Fundación Universitaria de Ciencias de la Salud, Bogota, Colombia

Open Randomized Controlled Trial to Evaluate the Efficacy and Safety of Remifentanil Versus Nitrous Oxide in External Cephalic Version at Term in Singleton Pregnancy in Breech Presentation

Phase 3

Completed

Conditions: Non-cephalic Presentation
Complications; Cesarean Section
Fetus or Neonate Affected by External Version Before Labor
Pregnancy Complications
Inhalation of Nitrous Oxide

Interventions: Drug: Nitrous Oxide
Drug: Remifentanil

First Posted Date: 2012-11-28

Last Posted Date: 2015-02-18

Lead Sponsor: Hospital de Cruces

Target Recruit Count: 120

Registration Number: NCT01735669

Locations: 🇪🇸
Hospital Universitario Cruces, Barakaldo, Bizkaia, Spain

The Effect Site Concentration of Remifentanil for Preventing QTc Interval Prolongation During Intubation Under Propofol-remifentanil Anesthesia in Elderly Patients

Not Applicable

Completed

Conditions: General Surgery With Endotracheal Intubation

Interventions: Drug: remifentanil

First Posted Date: 2012-11-02

Last Posted Date: 2013-06-18

Lead Sponsor: Severance Hospital

Target Recruit Count: 50

Registration Number: NCT01720498

Locations: 🇰🇷
Department of Anesthesiology and Pain Medicine and Anesthesia and Pain Research Institute, Yonsei University College of Medicine, Seoul, Korea, Republic of

Vagotonic Effect of Remifentanil and Autonomic Nervous System Activity.

Phase 4

Completed

Conditions: Autonomic Nervous System Activity

Interventions: Drug: Remifentanil

First Posted Date: 2012-10-25

Last Posted Date: 2015-10-02

Lead Sponsor: Medical University of Gdansk

Target Recruit Count: 70

Registration Number: NCT01714388

Locations: 🇵🇱
Medical University of Gdansk, Gdansk, Poland

Opioid-induced Hyperalgesia After Remifentanil Infusion

Phase 4

Completed

Conditions: Hyperalgesia

Interventions: Drug: Remifentanil

First Posted Date: 2012-10-08

Last Posted Date: 2014-10-29

Lead Sponsor: Oslo University Hospital

Target Recruit Count: 16

Registration Number: NCT01702389

Locations: 🇳🇴
Oslo University Hospital, Oslo, Norway

Remifentanil Only vs. Midazolam and Meperidine During Elective Colonoscopy

Phase 4

Completed

Conditions: Diagnostic Colonoscopy Screening

Interventions: Drug: Remifentanil
Drug: Midazolam
Drug: placebo (for midazolam)
Drug: Meperidine
Drug: placebo (for meperidine)
Drug: placebo (for remifentanil)

First Posted Date: 2012-09-26

Last Posted Date: 2014-06-18

Lead Sponsor: Konkuk University Medical Center

Target Recruit Count: 60

Registration Number: NCT01693185

Locations: 🇰🇷
Konkuk University Medical Center, Seoul, Korea, Republic of

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