Doxycycline

Generic Name: Doxycycline

Brand Names: Acticlate, Adoxa, Apprilon, Atridox, Doryx, Doxy, Doxycin, Lymepak, Mondoxyne, Monodox, Morgidox, Okebo, Oracea, Periostat, Targadox, Vibramycin

Drug Type: Small Molecule

Chemical Formula: C_₂₂H_₂₄N_₂O_₈

CAS Number: 564-25-0

Unique Ingredient Identifier: 334895S862

Background: Doxycycline is a broad-spectrum antibiotic synthetically derived from oxytetracycline. It is a second-generation tetracycline that was first discovered in 1967. Second-generation tetracyclines exhibit lesser toxicity than first-generation tetracyclines. Doxycycline is used to treat a wide variety of gram-positive and gram-negative bacterial infections. It is also used to treat acne and malaria.

Indication: Doxycycline is indicated for the treatment of various infections by gram-positive and gram-negative bacteria, aerobes and anaerobes, as well other types of bacteria, including:

It is also used to treat infections caused by the following gram-negative microorganisms:

Associated Conditions: Acinetobacter Infections, Anthrax, Bacterial Infection caused by Enterobacter aerogenes, Bartonellosis, Brucellosis, Campylobacter Infection, Chancroid, Chlamydia Trachomatis Infection, Early Lyme Disease, Granuloma Inguinale, Infection Due to Escherichia Coli, Inhalational Anthrax, Klebsiella Infections, Lymphogranuloma Venereum, Malaria caused by Plasmodium falciparum, Nongonococcal urethritis, Plague caused by Yersinia pestis, Psittacosis, Rectal infection caused by Chlamydia Trachomatis, Relapsing fever caused by Borrelia recurrentis, Respiratory Tract Infection Bacterial, Rickettsial infectious disorders, Severe Acne, Sexually Transmitted Infections (STIs), Shigella Infection, Trachoma inclusion conjunctivitis, Tularemia, Vibrio Cholerae Infection, Acute Intestinal amebiasis, Susceptible Bacterial Infections, Uncomplicated endocervical infection, Uncomplicated urethral infection

Associated Therapies: -

Clinical Trials

Relationship of Periodontal Disease Treatment and Type 2 Diabetes Mellitus in the Gullah Population

Phase 4

Completed

Conditions: Periodontal Disease
Type 2 Diabetes Mellitus

Interventions: Drug: Placebo
Drug: Doxycycline

First Posted Date: 2013-02-25

Last Posted Date: 2018-10-04

Lead Sponsor: Medical University of South Carolina

Target Recruit Count: 113

Registration Number: NCT01798225

Effect of a Commonly Used Antibiotic, Doxycycline, in Women With Polycystic Ovarian Syndrome

Phase 3

Completed

Conditions: Polycystic Ovarian Syndrome (PCOS)
Irregular Menstrual Cycles
Androgen Excess

Interventions: Other: Sugar Pill
Drug: doxycycline

First Posted Date: 2013-02-11

Last Posted Date: 2016-01-13

Lead Sponsor: University of Rochester

Target Recruit Count: 10

Registration Number: NCT01788215

Locations: 🇺🇸
University of Rochester, Strong Fertility Center, Rochester, New York, United States

Oral Azithromycin Versus Doxycycline in Posterior Blepharitis

Phase 2

Completed

Conditions: Posterior Blepharitis

Interventions: Drug: Azithromycin
Drug: Doxycycline

First Posted Date: 2013-02-05

Last Posted Date: 2014-02-12

Lead Sponsor: Tehran University of Medical Sciences

Target Recruit Count: 100

Registration Number: NCT01783860

Locations: 🇮🇷
Rassoul Akram Hospital, Tehran, Iran, Islamic Republic of

Antibiotics and Hydroxychloroquine in Crohn's

Phase 2

Completed

Conditions: Crohn's Disease

Interventions: Drug: Budesonide
Drug: Ciprofloxacin
Drug: Doxycycline
Drug: Hydroxychloroquine

First Posted Date: 2013-02-04

Last Posted Date: 2019-10-31

Lead Sponsor: Royal Liverpool University Hospital

Target Recruit Count: 59

Registration Number: NCT01783106

Locations: 🇬🇧
Royal Liverpool and Broadgreen Unversity Hospitals Trust, Liverpool, Merseyside, United Kingdom

Non-Invasive Treatment of Abdominal Aortic Aneurysm Clinical Trial

Phase 2

Completed

Conditions: Aneurysm

Interventions: Drug: Doxycycline
Drug: Placebo

First Posted Date: 2012-12-28

Last Posted Date: 2021-11-26

Lead Sponsor: University of Maryland, Baltimore

Target Recruit Count: 261

Registration Number: NCT01756833

Locations: 🇺🇸
Vanderbilt University Medical Center, Nashville, Tennessee, United States
🇺🇸
Omaha VAMC, Omaha, Nebraska, United States
🇺🇸
University of South Florida Health Center, Tampa, Florida, United States

and more 19 locations