Doxycycline

Generic Name
Doxycycline
Brand Names
Acticlate, Adoxa, Apprilon, Atridox, Doryx, Doxy, Doxycin, Lymepak, Mondoxyne, Monodox, Morgidox, Okebo, Oracea, Periostat, Targadox, Vibramycin
Drug Type
Small Molecule
Chemical Formula
C22H24N2O8
CAS Number
564-25-0
Unique Ingredient Identifier
334895S862
Background

Doxycycline is a broad-spectrum antibiotic synthetically derived from oxytetracycline. It is a second-generation tetracycline that was first discovered in 1967. Second-generation tetracyclines exhibit lesser toxicity than first-generation tetracyclines. Doxycycline is used to treat a wide variety of gram-positive and gram-negative bacterial infections. It is...

Indication

Doxycycline is indicated for the treatment of various infections by gram-positive and gram-negative bacteria, aerobes and anaerobes, as well other types of bacteria, including:

It is also used to treat infections caused by the following gram-negative microorganisms:

Associated Conditions
Acinetobacter Infections, Anthrax, Bacterial Infection caused by Enterobacter aerogenes, Bartonellosis, Brucellosis, Campylobacter Infection, Chancroid, Chlamydia Trachomatis Infection, Early Lyme Disease, Granuloma Inguinale, Infection Due to Escherichia Coli, Inhalational Anthrax, Klebsiella Infections, Lymphogranuloma Venereum, Malaria caused by Plasmodium falciparum, Nongonococcal urethritis, Plague caused by Yersinia pestis, Psittacosis, Rectal infection caused by Chlamydia Trachomatis, Relapsing fever caused by Borrelia recurrentis, Respiratory Tract Infection Bacterial, Rickettsial infectious disorders, Severe Acne, Sexually Transmitted Infections (STIs), Shigella Infection, Trachoma inclusion conjunctivitis, Tularemia, Vibrio Cholerae Infection, Acute Intestinal amebiasis, Susceptible Bacterial Infections, Uncomplicated endocervical infection, Uncomplicated urethral infection
Associated Therapies
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Tetracycline-Derivatives for Treatment of Cerebral Arteriovenous Malformations and Aneurysms

First Posted Date
2005-10-25
Last Posted Date
2013-10-09
Lead Sponsor
University of California, San Francisco
Target Recruit Count
26
Registration Number
NCT00243893
Locations
🇺🇸

University of California, San Francisco, California, United States

Serum Levels of Doxycycline at the Time of Abortion With Two Dosing Regimens

Phase 4
Completed
Conditions
First Posted Date
2005-09-15
Last Posted Date
2016-01-29
Lead Sponsor
University of Pittsburgh
Target Recruit Count
40
Registration Number
NCT00177333
Locations
🇺🇸

Magee-Womens Hospital, Pittsburgh, Pennsylvania, United States

Placebo Versus Antibiotics in Acute Exacerbations of Chronic Obstructive Pulmonary Disease (COPD)

Phase 4
Completed
Conditions
First Posted Date
2005-09-15
Last Posted Date
2008-09-29
Lead Sponsor
Medical Center Alkmaar
Target Recruit Count
258
Registration Number
NCT00170222
Locations
🇳🇱

Medisch centrum Alkmaar, Alkmaar, Noord-holland, Netherlands

Effect of Intravenous Ceftriaxone and Oral Doxycycline for Lyme Neuroborreliosis

Phase 3
Completed
Conditions
Interventions
First Posted Date
2005-08-30
Last Posted Date
2023-05-06
Lead Sponsor
Sorlandet Hospital HF
Target Recruit Count
120
Registration Number
NCT00138801
Locations
🇳🇴

Sørlandet Sykehus HF, Kristiansand, Vest-Agder, Norway

A Clinical Trial to Determine the Effects of 40 Mg Doxycycline Versus a Placebo Control for the Treatment of Rosacea

Phase 3
Completed
Conditions
First Posted Date
2005-08-04
Last Posted Date
2005-08-19
Lead Sponsor
CollaGenex Pharmaceuticals
Target Recruit Count
528
Registration Number
NCT00126399

Adjunctive Treatment With Doxycycline to Enhance the Durability of Endovascular Aortic Aneurysm Repair

Not Applicable
Completed
Conditions
First Posted Date
2005-08-03
Last Posted Date
2010-03-04
Lead Sponsor
The Foundation for Barnes-Jewish Hospital
Target Recruit Count
75
Registration Number
NCT00126204
Locations
🇺🇸

Washington University School of Medicine / Barnes-Jewish Hospital, St. Louis, Missouri, United States

Bleomycin, Doxycycline, or Talc in Treating Patients With Malignant Pleural Effusions

Phase 3
Completed
Conditions
First Posted Date
2004-09-02
Last Posted Date
2023-06-22
Lead Sponsor
Eastern Cooperative Oncology Group
Target Recruit Count
480
Registration Number
NCT00002872

Effect of Three Periodontal Therapies in Current Smokers and Non-Smokers

First Posted Date
2003-08-05
Last Posted Date
2013-04-22
Lead Sponsor
The Forsyth Institute
Target Recruit Count
146
Registration Number
NCT00066066
Locations
🇺🇸

Department of Periodontology, Cambridge, Massachusetts, United States

Norplant and Irregular Bleeding/Spotting

First Posted Date
2003-07-15
Last Posted Date
2005-06-24
Lead Sponsor
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Target Recruit Count
50
Registration Number
NCT00064766
Locations
🇺🇸

CONRAD Clinical Research Center, Eastern Virginia Medical School, Norfolk, Virginia, United States

Azithromycin/Bicillin Syphilis

First Posted Date
2002-03-07
Last Posted Date
2013-04-29
Lead Sponsor
National Institute of Allergy and Infectious Diseases (NIAID)
Target Recruit Count
593
Registration Number
NCT00031499
Locations
🇺🇸

Louisiana State University Health Sciences Center - Infectious Diseases, New Orleans, Louisiana, United States

🇲🇬

Hopitaly Mahabibo, Mahajanga Majunga, Mahajanga, Madagascar

🇺🇸

University of Alabama Hospital - Infectious Diseases, Birmingham, Alabama, United States

and more 7 locations
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