Doxycycline

Generic Name: Doxycycline

Brand Names: Acticlate, Adoxa, Apprilon, Atridox, Doryx, Doxy, Doxycin, Lymepak, Mondoxyne, Monodox, Morgidox, Okebo, Oracea, Periostat, Targadox, Vibramycin

Drug Type: Small Molecule

Chemical Formula: C_₂₂H_₂₄N_₂O_₈

CAS Number: 564-25-0

Unique Ingredient Identifier: 334895S862

Background: Doxycycline is a broad-spectrum antibiotic synthetically derived from oxytetracycline. It is a second-generation tetracycline that was first discovered in 1967. Second-generation tetracyclines exhibit lesser toxicity than first-generation tetracyclines. Doxycycline is used to treat a wide variety of gram-positive and gram-negative bacterial infections. It is...

Indication: Doxycycline is indicated for the treatment of various infections by gram-positive and gram-negative bacteria, aerobes and anaerobes, as well other types of bacteria, including:

It is also used to treat infections caused by the following gram-negative microorganisms:

Associated Conditions: Acinetobacter Infections, Anthrax, Bacterial Infection caused by Enterobacter aerogenes, Bartonellosis, Brucellosis, Campylobacter Infection, Chancroid, Chlamydia Trachomatis Infection, Early Lyme Disease, Granuloma Inguinale, Infection Due to Escherichia Coli, Inhalational Anthrax, Klebsiella Infections, Lymphogranuloma Venereum, Malaria caused by Plasmodium falciparum, Nongonococcal urethritis, Plague caused by Yersinia pestis, Psittacosis, Rectal infection caused by Chlamydia Trachomatis, Relapsing fever caused by Borrelia recurrentis, Respiratory Tract Infection Bacterial, Rickettsial infectious disorders, Severe Acne, Sexually Transmitted Infections (STIs), Shigella Infection, Trachoma inclusion conjunctivitis, Tularemia, Vibrio Cholerae Infection, Acute Intestinal amebiasis, Susceptible Bacterial Infections, Uncomplicated endocervical infection, Uncomplicated urethral infection

Associated Therapies: -

Clinical Trials

LOAD VS Levofloxacine Concomitant

Phase 4

Conditions: Helicobacter Pylori Infection

Interventions: Drug: Levofloxacin 500mg
Drug: Doxycycline

First Posted Date: 2020-11-12

Last Posted Date: 2020-11-12

Lead Sponsor: Damascus Hospital

Target Recruit Count: 80

Registration Number: NCT04626193

Locations: 🇸🇾
General Assembly of Damascus Hospital, Damascus, Syrian Arab Republic

OD-doxy-PNV-COVID-19 Old Drug " DOXY " for Prevention of New Virus " COVID-19 "

Phase 3

Completed

Conditions: Covid19

Interventions: Drug: Doxycyclin

First Posted Date: 2020-10-14

Last Posted Date: 2021-11-19

Lead Sponsor: Hedi Gharsallah

Target Recruit Count: 194

Registration Number: NCT04584567

Locations: 🇹🇳
Military Hospital of Tunis, Tunis, Montfleury, Tunisia

Evaluation of the Efficacy and Safety of Treatments for Patients Hospitalized for COVID-19 Infection Without Signs of Acute Respiratory Failure, in Tunisia

Phase 3

Withdrawn

Conditions: COVID 19
Patients Hospitalized

Interventions: Drug: HCQ
Drug: Azithromycin
Drug: Doxycycline
Dietary Supplement: Zinc

First Posted Date: 2020-08-27

Last Posted Date: 2020-08-27

Lead Sponsor: Abderrahmane Mami Hospital

Registration Number: NCT04528927

Locations: 🇹🇳
Eshmoun Clinical Research Centre, Tunis, Tunisia

RepurpoSing Old Drugs TO SuppRess a Modern Threat: COVID-19 STORM

Phase 2

Withdrawn

Conditions: Cytokine Storm
SARS-CoV-2

Interventions: Drug: Placebo
Drug: Doxycycline

First Posted Date: 2020-06-16

Last Posted Date: 2021-04-19

Lead Sponsor: Temple University

Registration Number: NCT04433078

Locations: 🇺🇸
Temple University Hospital, Philadelphia, Pennsylvania, United States

DYNAMIC Study (DoxycYcliNe AMbulatoIre COVID-19)

Phase 3

Withdrawn

Conditions: COVID19

Interventions: Drug: Doxycycline
Drug: Placebo

First Posted Date: 2020-05-01

Last Posted Date: 2022-04-20

Lead Sponsor: Nantes University Hospital

Registration Number: NCT04371952

Locations: 🇫🇷
CHU Caen, Caen, France
🇫🇷
CHU Grenoble, Grenoble, France
🇫🇷
CHU Bordeaux, Bordeaux, France

and more 3 locations

Hydroxychloroquine and Zinc With Either Azithromycin or Doxycycline for Treatment of COVID-19 in Outpatient Setting

Phase 4

Completed

Conditions: COVID-19

Interventions: Drug: Hydroxychloroquine
Drug: Zinc Sulfate
Drug: Azithromycin
Drug: Doxycycline

First Posted Date: 2020-05-01

Last Posted Date: 2020-12-09

Lead Sponsor: St. Francis Hospital, New York

Target Recruit Count: 18

Registration Number: NCT04370782

Locations: 🇺🇸
St Francis Hospital, Roslyn, New York, United States

Comparing Efficacy of 14-day Therapy Doxycycline With Bismuth Subsalicylate Versus Levofloxacin With Tinadizole on Treatment Helicobacter Pylori

Phase 4

Completed

Conditions: Helicobacter Pylori Infection

Interventions: Drug: Doxycycline
Drug: Levofloxacin 500mg

First Posted Date: 2020-04-16

Last Posted Date: 2020-09-16

Lead Sponsor: Damascus Hospital

Target Recruit Count: 78

Registration Number: NCT04348786

Locations: 🇸🇾
General Assembly of Damascus Hospital, Damascus, Syrian Arab Republic

Finding the Optimal Regimen for Mycobacterium Abscessus Treatment

Phase 2

Recruiting

Conditions: Pulmonary Disease Due to Mycobacteria (Diagnosis)

Interventions: Drug: Amikacin
Drug: Tigecycline
Drug: Imipenem
Drug: Cefoxitin
Drug: Linezolid
Drug: Azithromycin
Drug: co-trimoxazole
Drug: Clarithromycin
Drug: Clofazimine
Drug: Doxycycline
Drug: Moxifloxacin
Drug: Ethambutol
Drug: Bedaquiline
Drug: Rifabutin

First Posted Date: 2020-03-17

Last Posted Date: 2024-12-11

Lead Sponsor: The University of Queensland

Target Recruit Count: 300

Registration Number: NCT04310930

Locations: 🇦🇺
St George Hospital, Kogarah, New South Wales, Australia
🇦🇺
Austin Hospital, Heidelberg, Victoria, Australia
🇦🇺
Royal Melbourne Hospital, Parkville, Victoria, Australia

and more 47 locations