Zonisamide
- Generic Name
- Zonisamide
- Brand Names
- Zonegran, Zonisade, Zonisamide Mylan
- Drug Type
- Small Molecule
- Chemical Formula
- C8H8N2O3S
- CAS Number
- 68291-97-4
- Unique Ingredient Identifier
- 459384H98V
- Background
Zonisamide is a sulfonamide anticonvulsant used as an adjunctive therapy in adults with partial-onset seizures. Zonisamide may act by blocking repetitive firing of voltage-gated sodium channels, leading to a reduction of T-type calcium channel currents or by binding allosterically to GABA receptors. This latter action may inhibit the uptake of the inhibitory neurotransmitter GABA while enhancing the uptake of the excitatory neurotransmitter glutamate. Zonisamide represents an alternative for patients that remain refractory to established antiepileptic drugs. In 1989, it was approved for commercial use in Japan. The US and Europe approved it in 2000 and 2005, respectively.
- Indication
Zonisamide capsules are indicated as adjunctive therapy in the treatment of partial seizures in adults with epilepsy. Zonisamide oral suspension is indicated as adjunctive therapy for the treatment of partial-onset seizures in adults and pediatric patients 16 years of age and older.
- Associated Conditions
- Partial-Onset Seizures
- Associated Therapies
- -
Open-label, Multi-center Trial of Zonisamide as Adjunctive Therapy in Patients With Uncontrolled Partial Epilepsy
- First Posted Date
- 2010-06-10
- Last Posted Date
- 2022-01-04
- Lead Sponsor
- Eisai Korea Inc.
- Target Recruit Count
- 121
- Registration Number
- NCT01140867
- Locations
- 🇰🇷
Kangdong Sacred Heart Hosp., Dept. of Neurology, Seoul, Korea, Republic of
🇰🇷Bundang CHA Hospital, Dept. of Neurology, Seongnam, Korea, Republic of
🇰🇷Dong-A University Hospital, Dept. of Neurology, Busan, Korea, Republic of
Effect of Zonisamide on Cocaine Reinforcement, Craving, and Relapse
- Conditions
- Cocaine Dependence
- Interventions
- Drug: PlaceboDrug: ZonisamideDrug: Cocaine HydrochlorideBehavioral: Neurocognitive and Performance BatteryBehavioral: Smoking Assessments
- First Posted Date
- 2010-06-07
- Last Posted Date
- 2017-09-05
- Lead Sponsor
- Johns Hopkins University
- Target Recruit Count
- 19
- Registration Number
- NCT01137890
- Locations
- 🇺🇸
Behavioral Pharmacology Research Unit, Baltimore, Maryland, United States
A Study to Assess the Efficacy and Safety of Adjunctive Zonisamide in Paediatric Partial Onset Seizures (CATZ Extension Study)
- First Posted Date
- 2010-06-04
- Last Posted Date
- 2016-01-25
- Lead Sponsor
- Eisai Limited
- Target Recruit Count
- 144
- Registration Number
- NCT01136954
Comparative Study of Zonisamide and Carbamazepine as an Initial Monotherapy: Efficacy and Safety Evaluation
- First Posted Date
- 2010-05-20
- Last Posted Date
- 2022-01-04
- Lead Sponsor
- Eisai Korea Inc.
- Target Recruit Count
- 200
- Registration Number
- NCT01127256
- Locations
- 🇰🇷
Seoul National Univ. Bundang Hosp., Bundang, Korea, Republic of
🇰🇷Dongguk Univ. Ilsan Hosp., Ilsan, Korea, Republic of
🇰🇷Boramae Medical Center, Seoul, Korea, Republic of
Interdisciplinary Study of Two Novel Anticonvulsants in Alcoholism
- Conditions
- Alcohol DependenceAlcohol AbuseAlcoholism
- Interventions
- First Posted Date
- 2009-03-17
- Last Posted Date
- 2015-04-28
- Lead Sponsor
- Boston Medical Center
- Target Recruit Count
- 85
- Registration Number
- NCT00862563
- Locations
- 🇺🇸
Boston University School of Medicine, Boston, Massachusetts, United States
Assessing The Long-Term Safety And To Explore The Long-Term Efficacy Of Zonisamide As Monotherapy In Newly Diagnosed Partial Seizures
- First Posted Date
- 2009-02-20
- Last Posted Date
- 2015-12-24
- Lead Sponsor
- Eisai Inc.
- Target Recruit Count
- 295
- Registration Number
- NCT00848549
Cognitive Side Effects of Commonly Prescribed Medications in Pediatric Migraine
- Conditions
- Migraine
- Interventions
- First Posted Date
- 2008-10-22
- Last Posted Date
- 2020-12-17
- Lead Sponsor
- University of South Alabama
- Registration Number
- NCT00777218
- Locations
- 🇺🇸
University of South Alabama Department of Neurology, Mobile, Alabama, United States
Comparing The Effect On Cognition Of Adjunctive Therapy With Zonisamide Versus Sodium Valproate
- First Posted Date
- 2008-07-11
- Last Posted Date
- 2015-11-03
- Lead Sponsor
- Eisai Limited
- Target Recruit Count
- 2
- Registration Number
- NCT00713622
- Locations
- 🇫🇮
Kuopio University Hospital, Kuopio, Finland
🇦🇹Universitae Klinik fur Neurologiet, Innsbruck, Austria
Efficacy and Safety of Adjunctive Zonisamide in Myoclonic Seizures Associated With Idiopathic Generalised Epilepsy
- First Posted Date
- 2008-06-06
- Last Posted Date
- 2015-12-24
- Lead Sponsor
- Eisai Limited
- Target Recruit Count
- 10
- Registration Number
- NCT00693017
- Locations
- 🇦🇺
Strategic Health Evaluators Pty Ltd, Chatswood, New South Wales, Australia
🇦🇺The Prince of Wales Hospital, Randwick, New South Wales, Australia
🇭🇺Vas County Markusovszky Hospital, Szombathely, Hungary
Adjunctive Zonisamide in Primary Generalised Tonic Clonic Seizures
- First Posted Date
- 2008-06-06
- Last Posted Date
- 2017-03-14
- Lead Sponsor
- Eisai Limited
- Target Recruit Count
- 21
- Registration Number
- NCT00692003
- Locations
- 🇨🇿
Fakultni nemocnice Plzen, Plzen, Czech Republic
🇪🇪West-Tallinn Central Hospital, Tallinn, Estonia
🇵🇱Wojewodzki Szpital Specjalistyczny im. M. Kopernika, Gdansk, Poland
Drug Development Updates
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