Precursor of an alkylating nitrogen mustard antineoplastic and immunosuppressive agent that must be activated in the liver to form the active aldophosphamide. It has been used in the treatment of lymphoma and leukemia. Its side effect, alopecia, has been used for defleecing sheep. Cyclophosphamide may also cause sterility, birth defects, mutations, and cancer.
Cyclophosphamide is indicated for the treatment of malignant lymphomas, multiple myeloma, leukemias, mycosis fungoides (advanced disease), neuroblastoma (disseminated disease), adenocarcinoma of the ovary, retinoblastoma, and carcinoma of the breast. It is also indicated for the treatment of biopsy-proven minimal change nephrotic syndrome in pediatric patients.
Fred Hutch/University of Washington Cancer Consortium, Seattle, Washington, United States
MD Anderson Cancer Center, Houston, Texas, United States
Georgetown Lombardi Comprehensive Cancer Center, Washington, District of Columbia, United States
Banner MD Anderson Cancer Center, Gilbert, Arizona, United States
Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand
Henan Cancer Hospital, Zhengzhou, Henan, China
M D Anderson Cancer Center, Houston, Texas, United States
University of Michigan Cancer Center, Ann Arbor, Michigan, United States
City of Hope Medical Center, Duarte, California, United States
M D Anderson Cancer Center, Houston, Texas, United States
Henan Province of TCM, Zhengzhou, Henan, China
University of Pennsylvania, Philadelphia, Pennsylvania, United States
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