Dantrolene
- Generic Name
- Dantrolene
- Brand Names
- Dantrium, Revonto, Ryanodex, Agilus
- Drug Type
- Small Molecule
- Chemical Formula
- C14H10N4O5
- CAS Number
- 7261-97-4
- Unique Ingredient Identifier
- F64QU97QCR
- Background
Chemically, dantrolene is a hydantoin derivative, but does not exhibit antiepileptic activity like other hydantoin derivates such as phenytoin.
- Indication
For use, along with appropriate supportive measures, for the management of the fulminant hypermetabolism of skeletal muscle characteristic of malignant hyperthermia crises in patients of all ages. Also used preoperatively, and sometimes postoperatively, to prevent or attenuate the development of clinical and laboratory signs of malignant hyperthermia in indi...
- Associated Conditions
- Malignant Hyperthermia, Spasticity
- Associated Therapies
- -
The Use of Dantrolene to Improve Analgesia in Posterior Lumbar Surgery
- First Posted Date
- 2018-12-03
- Last Posted Date
- 2024-07-11
- Lead Sponsor
- Beth Israel Deaconess Medical Center
- Target Recruit Count
- 90
- Registration Number
- NCT03762109
- Locations
- 🇺🇸
Beth Israel Deaconess Medical Center, Boston, Massachusetts, United States
Targeting Residual Activity By Precision, Biomarker-Guided Combination Therapies of Multiple Sclerosis (TRAP-MS)
- Conditions
- Interventions
- First Posted Date
- 2017-04-12
- Last Posted Date
- 2024-12-02
- Target Recruit Count
- 250
- Registration Number
- NCT03109288
- Locations
- 🇺🇸
National Institutes of Health Clinical Center, Bethesda, Maryland, United States
Study of Human Non-Shivering Thermogenesis and Basal Metabolic Rate
- Conditions
- Interventions
- First Posted Date
- 2013-09-25
- Last Posted Date
- 2024-10-16
- Target Recruit Count
- 47
- Registration Number
- NCT01950520
- Locations
- 🇺🇸
National Institutes of Health Clinical Center, Bethesda, Maryland, United States
Safety Study of Dantrolene in Subarachnoid Hemorrhage
- Conditions
- Interventions
- First Posted Date
- 2009-12-03
- Last Posted Date
- 2015-03-05
- Lead Sponsor
- University of Massachusetts, Worcester
- Target Recruit Count
- 31
- Registration Number
- NCT01024972
- Locations
- 🇺🇸
UMASS Medical School / UMass Memorial Medical Center, Worcester, Massachusetts, United States
Safety Study of Dantrolene to Treat Cerebral Vasospasm After Subarachnoid Hemorrhage
- Conditions
- Interventions
- First Posted Date
- 2009-08-25
- Last Posted Date
- 2012-05-25
- Lead Sponsor
- University of Massachusetts, Worcester
- Target Recruit Count
- 10
- Registration Number
- NCT00964548
- Locations
- 🇺🇸
UMASS Memorial Medical Center/UMASS Medical School, Worcester, Massachusetts, United States
🇺🇸Massachusetts General Hospital, Boston, Massachusetts, United States
Dantrolene for Treatment of Hyperthermia in Subarachnoidal Hemorrhage (SAH)
- First Posted Date
- 2008-11-24
- Last Posted Date
- 2011-05-12
- Lead Sponsor
- Medical University of Vienna
- Target Recruit Count
- 34
- Registration Number
- NCT00796900
- Locations
- 🇦🇹
Medical University Vienna, Vienna, Austria
Drug Development Updates
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