Indocyanine green acid form

Generic Name: Indocyanine green acid form

Brand Names: Ic-green

Drug Type: Small Molecule

Chemical Formula: C_₄₃H_₄₈N_₂O_₆S_₂

CAS Number: 28782-33-4

Unique Ingredient Identifier: C4V974V932

Background: Indocyanine Green is a water soluble, tricarbocyanine dye with a peak spectral absorption at 800 nm. The chemical name for Indocyanine Green is 1 H-Benz[e]indolium, 2-[7-[1,3-dihydro-1,1-dimethyl-3-(4-sulfobutyl)-2H-benz[e] indol-2-ylidene]-1,3,5-heptatrienyl]-1,1-dimethyl-3-(4-sulfobutyl)-,hydroxide, inner salt, sodium salt. Indocyanine Green for Injection USP has a pH of approximately 6.5 when reconstituted. Each vial of Indocyanine Green for Injection USP contains 25 mg of Indocyanine Green as a sterile lyophilized powder with no more than 5% sodium iodide.

Indication: For Determining Cardiac Output, Hepatic Function and Liver Blood Flow

For ophthalmic angiography

Clinical Trials

ICG-fluorescence Imaging for Intraoperative Breast Cancer Margins Evaluation: a Dose-timing Study

Not Applicable

Recruiting

Conditions: Breast Cancer

Interventions: Drug: Indocyanine green

First Posted Date: 2024-01-26

Last Posted Date: 2025-02-26

Lead Sponsor: Jules Bordet Institute

Target Recruit Count: 250

Registration Number: NCT06227338

Locations: 🇧🇪
Jules Bordet Institute, Brussels, Belgium

Does Fluorescence With or Without Indocyanine Green Improve Parathyroid Identification and Preservation

Phase 4

Recruiting

Conditions: Parathyroid Dysfunction
Adenoma

Interventions: Drug: Indocyanine green
Device: SPY Portable Handheld Imaging

First Posted Date: 2023-12-13

Last Posted Date: 2025-05-06

Lead Sponsor: University of Alabama at Birmingham

Target Recruit Count: 417

Registration Number: NCT06169735

Locations: 🇺🇸
UAB Callahan Eye, Birmingham, Alabama, United States

Evaluation of Neuroma Perfusion with Indocyanine Green Fluorescence Angiography

Phase 4

Withdrawn

Conditions: Neuroma of Upper Limb
Neuroma of Lower Limb
Neuroma
Neuroma Amputation

Interventions: Drug: Indocyanine green

First Posted Date: 2023-12-11

Last Posted Date: 2025-01-01

Lead Sponsor: Northwestern University

Target Recruit Count: 25

Registration Number: NCT06164392

Locations: 🇺🇸
Northwestern University, Chicago, Illinois, United States

ICG Indocyanine Green in Reconstructive Surgery

Conditions: Surgery
Fluorescence

Interventions: Drug: Indocyanine green

First Posted Date: 2023-11-13

Last Posted Date: 2023-11-13

Lead Sponsor: Amsterdam UMC, location VUmc

Target Recruit Count: 160

Registration Number: NCT06129669

Locations: 🇳🇱
Amsterdam UMC, Amsterdam, Netherlands

SLN Mapping and ICG Dye for Vulvar Cancer

Not yet recruiting

Conditions: Vulva Cancer

Interventions: Drug: Indocyanine green

First Posted Date: 2023-09-13

Last Posted Date: 2025-04-20

Lead Sponsor: Tufts Medical Center

Target Recruit Count: 10

Registration Number: NCT06035068

Locations: 🇺🇸
Tufts Medical Center, Boston, Massachusetts, United States

A French Observational Study of Indocyanine Green for Patients With Breast Cancer Having a Sentinel Lymph Node Biopsy.

Completed

Conditions: Breast Cancer

First Posted Date: 2023-09-06

Last Posted Date: 2024-05-10

Lead Sponsor: BTG International Inc.

Target Recruit Count: 101

Registration Number: NCT06024213

Locations: 🇫🇷
Hôpital Européen Georges-Pompidou Paris, Paris, Île-de-France, France
🇫🇷
Institut de Cancérologie de Lorraine, Vandœuvre-lès-Nancy, Meurthe-et-Moselle, France
🇫🇷
CHU de Saint-Etienne, Saint-Etienne, Loire, France

and more 3 locations

The Use of Indocyanine Green to Visualize Blood Flow to the Gastrojejunostomy During Bariatric Surgery.

Phase 4

Recruiting

Conditions: Ulcer, Gastric
Obesity, Morbid

Interventions: Drug: Indocyanine green
Device: Stryker 1688 AIM system

First Posted Date: 2023-08-21

Last Posted Date: 2025-04-09

Lead Sponsor: University Health Network, Toronto

Target Recruit Count: 300

Registration Number: NCT06002906

Locations: 🇨🇦
Toronto Western Hospital, University Health Network, Toronto, Ontario, Canada

High Quality Fluorescent Cholangiography

Phase 2

Completed

Conditions: Extrahepatic Biliary Tree Injury

Interventions: Drug: Indocyanine green

First Posted Date: 2023-07-03

Last Posted Date: 2023-12-18

Lead Sponsor: Zhujiang Hospital

Target Recruit Count: 168

Registration Number: NCT05926856

Locations: 🇨🇳
Southern Medical University, Guangzhou, Guangdong, China

Sentinel Lymph Node Biopsy in Rectal Cancer

Not Applicable

Not yet recruiting

Conditions: Rectal Cancer Stage III
Rectal Cancer Stage IV

Interventions: Procedure: Sentinel lymph node biopsy
Drug: Indocyanine green solution
Device: fluorescence laparoscope
Diagnostic Test: pathological examination
Diagnostic Test: rapid frozen pathological examination
Procedure: total mesorectal excision

First Posted Date: 2023-04-26

Last Posted Date: 2023-04-28

Lead Sponsor: National Cancer Center, China

Target Recruit Count: 87

Registration Number: NCT05830890

Locations: 🇨🇳
National Cancer Center, Beijing, Beijing, China

Fluorescence Imaging with Indocyanine Green(ICG) in Endoscopic Spinal Surgery

Phase 1

Active, not recruiting

Conditions: Disc Herniation

Interventions: Drug: Indocyanine Green
Device: Fluorescence imaging

First Posted Date: 2023-04-11

Last Posted Date: 2025-01-27

Lead Sponsor: Zhongnan Hospital

Target Recruit Count: 40

Registration Number: NCT05808140

Locations: 🇨🇳
Department of Spine Surgery and Musculoskeletal Tumor, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China

Drug Development Updates

Stay informed with timely notifications on clinical trials, regulatory changes, and research advancements related to this medication.

Home Terms & Conditions Privacy Policy