Vinorelbine is an anti-mitotic chemotherapy drug that is used in the treatment of several types of malignancies, including breast cancer and non-small cell lung cancer (NSCLC) . It was initially approved in the USA in 1990's for the treatment of NSCLC .
It is a third-generation vinca alkaloid. The introduction of third-generation drugs (vinorelbine, gemcitabine, taxanes) in platinum combination improved survival of patients with advanced NSCLC, with very similar results from the various drugs. Treatment toxicities are considerable in the combination treatment setting .
A study was done on the clearance rate of vinorelbine on individuals with various single polymorphonuclear mutations. It was found that there was 4.3-fold variation in vinorelbine clearance across the cohort, suggesting a strong influence of genetics on the clearance of this drug .
Vinorelbine tartrate is indicated for adults in the treatment of advanced non-small cell lung cancer (NSCLC), as a single therapy or in combination with other chemotherapeutic drugs .
Used in relapsed or refractory Hodgkin lymphoma, in combination with other chemotherapy agents .
For the treatment of desmoid tumor or aggressive fibromatosis, in combination with methotrexate .
For the treatment of recurrent or metastatic squamous cell head and neck cancer .
For the treatment of recurrent ovarian cancer .
For the treatment of metastatic breast cancer, in patients previously treated with anthracyline and/or taxane therapy .
For the treatment of HER2-positive, trastuzumab-resistant, advanced breast cancer in patients previously treated with a taxane, in combination with trastuzumab and everolimus .
Willis-Knighton Physician Network/Gynecologic Oncology Associates, Shreveport, Louisiana, United States
Maryland Oncology Hematology, P.A., Columbia, Maryland, United States
Fondazione Policlinico Universitario Agostino, Roma, Other, Italy
Sun Yat Sen Memorial Hospital,Sun Yat sen University, Guangzhou, Guangdong, China
University Unit of Pediatric Oncology-hematology - Children's Hospital Agia Sophia, Athens, Greece
Rambam Health Care Campus, Haifa, Israel
Hadassah University Medical Centre, Jerusalem, Israel
Connecticut Children's Medical Center, Hartford, Connecticut, United States
University of Texas Southwestern Medical Center, Dallas, Texas, United States
Primary Children's Medical Center/Utah, Salt Lake City, Utah, United States
Cancer Hospital/ Institute, Fudan University, Shanghai, Shanghai, China
European Institute of Oncology, Milan, Italy
Breast cancer institute of Fudan University Cancer Hospital, Shanghai, Shanghai, China
Rebecca Phelan, Los Angeles, California, United States
Zhi-Ming Shao, Shanghai, China
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