A Comprehensive Monograph on Terbutaline (DB00871)

1. Terbutaline: An Overview and Summary of Key Properties

1.1. Introduction

Terbutaline is a synthetic sympathomimetic amine belonging to the phenylethanolamine chemical class.[1] Pharmacologically, it is classified as a selective, short-acting beta-2 (

β2​) adrenergic receptor agonist (SABA).[2] Its primary and approved therapeutic function is as a bronchodilator for the prevention and reversal of bronchospasm in patients with reversible obstructive airway diseases, including asthma, chronic bronchitis, and emphysema.[5] By selectively targeting

β2​ receptors in the bronchial smooth muscle, terbutaline provides rapid relief from symptoms such as wheezing, shortness of breath, and chest tightness, making it a cornerstone of "reliever" or "rescue" therapy in respiratory medicine.[3]

1.2. Executive Summary

This report provides an exhaustive analysis of terbutaline, synthesizing its chemical, pharmacological, clinical, and safety profiles. The clinical narrative of terbutaline is defined by a profound duality. On one hand, it is a well-established, effective, and widely used bronchodilator for a common set of respiratory conditions.[5] On the other hand, its off-label use as a tocolytic agent to manage preterm labor has been associated with significant risks, leading to severe regulatory actions.