Desloratadine
- Generic Name
- Desloratadine
- Brand Names
- Aerius, Clarinex, Clarinex-D, Neoclarityn, Desloratadine ratiopharm, Desloratadine Teva, Desloratadine Actavis, Dasselta, Azomyr
- Drug Type
- Small Molecule
- Chemical Formula
- C19H19ClN2
- CAS Number
- 100643-71-8
- Unique Ingredient Identifier
- FVF865388R
- Background
Desloratadine is a second generation, tricyclic antihistamine that which has a selective and peripheral H1-antagonist action. It is the active descarboethoxy metabolite of loratidine (a second generation histamine). Desloratidine has a long-lasting effect and does not cause drowsiness because it does not readily enter the central nervous system.
- Indication
For the relief of symptoms of seasonal allergic rhinitis, perennial (non-seasonal) allergic rhinitis. Desloratidine is also used for the sympomatic treatment of pruritus and urticaria (hives) associated with chronic idiopathic urticaria.
- Associated Conditions
- Allergic Rhinitis (AR), Asthma, Chronic Idiopathic Urticaria, Common Cold, Nasal Congestion, Perennial Allergic Rhinitis (PAR), Seasonal Allergic Rhinitis, Nasal symptoms, Non-nasal symptoms
- Associated Therapies
- Antihistamine
A Comparative Double-Blind, Double- Dummy Study of Desloratadine (DL) 5 MG Once Daily, Cetirizine 10 MG Once Daily, and Placebo Once Daily in Patients With Chronic Idiopathic Urticaria (Study P03735)
- First Posted Date
- 2008-09-11
- Last Posted Date
- 2024-08-15
- Lead Sponsor
- Organon and Co
- Target Recruit Count
- 174
- Registration Number
- NCT00751218
Safety of Aerius Syrup in Pediatric Patients Aged 1-5 Years Old With Allergic Rhinitis or Chronic Idiopathic Urticaria (Study P04446AM1)(COMPLETED)
- First Posted Date
- 2008-07-29
- Last Posted Date
- 2022-02-09
- Lead Sponsor
- Organon and Co
- Target Recruit Count
- 100
- Registration Number
- NCT00723736
Evaluation of Desloratadine When Used in Patients With Either Allergic Rhinitis or Chronic Idiopathic Urticaria
- First Posted Date
- 2008-07-29
- Last Posted Date
- 2022-02-09
- Lead Sponsor
- Organon and Co
- Target Recruit Count
- 3011
- Registration Number
- NCT00724698
A Study to Assess and Compare the Effects of 5 mg vs. 20 mg Desloratadine on the Development of Cold Urticaria Lesions
- First Posted Date
- 2008-01-25
- Last Posted Date
- 2008-01-25
- Lead Sponsor
- Charite University, Berlin, Germany
- Target Recruit Count
- 33
- Registration Number
- NCT00600847
- Locations
- 🇩🇪
Allergie-Centrum-Charité Berlin, Berlin, Germany
Effects of 5 mg vs. 20 mg Desloratadine on Skin Lesions in Patients With Chronic Urticaria (CU)
- First Posted Date
- 2008-01-22
- Last Posted Date
- 2012-05-31
- Lead Sponsor
- Charite University, Berlin, Germany
- Target Recruit Count
- 29
- Registration Number
- NCT00598611
- Locations
- 🇩🇪
Allergie-Centrum-Charite, Berlin, Germany
The Duration of the Suppressive Effects of Desloratadine on Allergen Prick Tests After Discontinuation (P04441)
- Conditions
- Interventions
- First Posted Date
- 2006-08-01
- Last Posted Date
- 2022-02-09
- Lead Sponsor
- Organon and Co
- Target Recruit Count
- 36
- Registration Number
- NCT00359138
A Study of the Effects of Desloratadine on Conjunctival Allergen Challenge-induced Ocular Signs and Symptoms (Study P04209)
- Conditions
- First Posted Date
- 2006-04-06
- Last Posted Date
- 2024-08-15
- Lead Sponsor
- Organon and Co
- Target Recruit Count
- 41
- Registration Number
- NCT00311844
CUTE (Chronic Urticaria Treatment Evaluation)
- Conditions
- Interventions
- First Posted Date
- 2005-12-12
- Last Posted Date
- 2011-08-31
- Lead Sponsor
- UCB Pharma
- Target Recruit Count
- 886
- Registration Number
- NCT00264303
Drug Development Updates
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