Desloratadine
- Generic Name
- Desloratadine
- Brand Names
- Aerius, Clarinex, Clarinex-D, Neoclarityn, Desloratadine ratiopharm, Desloratadine Teva, Desloratadine Actavis, Dasselta, Azomyr
- Drug Type
- Small Molecule
- Chemical Formula
- C19H19ClN2
- CAS Number
- 100643-71-8
- Unique Ingredient Identifier
- FVF865388R
- Background
Desloratadine is a second generation, tricyclic antihistamine that which has a selective and peripheral H1-antagonist action. It is the active descarboethoxy metabolite of loratidine (a second generation histamine). Desloratidine has a long-lasting effect and does not cause drowsiness because it does not readily enter the central nervous system.
- Indication
For the relief of symptoms of seasonal allergic rhinitis, perennial (non-seasonal) allergic rhinitis. Desloratidine is also used for the sympomatic treatment of pruritus and urticaria (hives) associated with chronic idiopathic urticaria.
- Associated Conditions
- Allergic Rhinitis (AR), Asthma, Chronic Idiopathic Urticaria, Common Cold, Nasal Congestion, Perennial Allergic Rhinitis (PAR), Seasonal Allergic Rhinitis, Nasal symptoms, Non-nasal symptoms
- Associated Therapies
- Antihistamine
Anti-inflammatory H1 Antihistamines Allergic Rhinitis
- First Posted Date
- 2015-07-24
- Last Posted Date
- 2015-07-24
- Lead Sponsor
- Iuliu Hatieganu University of Medicine and Pharmacy
- Target Recruit Count
- 115
- Registration Number
- NCT02507635
Efficacy and Safety Study of Desloratadine (MK-4117) in Japanese Participants With Seasonal Allergic Rhinitis (MK-4117-204)
- Conditions
- Seasonal Allergic Rhinitis
- Interventions
- Drug: Placebo
- First Posted Date
- 2014-12-19
- Last Posted Date
- 2024-05-17
- Lead Sponsor
- Organon and Co
- Target Recruit Count
- 449
- Registration Number
- NCT02320396
Anti-histamines and Methacholine Challenges.
- Conditions
- Asthma
- Interventions
- First Posted Date
- 2013-11-15
- Last Posted Date
- 2015-04-08
- Lead Sponsor
- Don Cockcroft
- Target Recruit Count
- 12
- Registration Number
- NCT01985789
- Locations
- 🇨🇦
University of Saskatchewan, Saskatoon, Saskatchewan, Canada
Evaluation of the Inhibitory Effect of 5 Anti-Histamines in Urticaria
- Conditions
- Urticaria
- Interventions
- First Posted Date
- 2013-09-12
- Last Posted Date
- 2014-02-19
- Lead Sponsor
- Grupo de Alergología Clínica y Experimental
- Target Recruit Count
- 150
- Registration Number
- NCT01940393
- Locations
- 🇨🇴
Medellin, Medellin, Antioquia, Colombia
A Study of the Efficacy and Safety of Desloratadine (MK-4117) in Japanese Participants With Perennial Allergic Rhinitis (MK-4117-200)
- Conditions
- Perennial Allergic Rhinitis
- Interventions
- Drug: Placebo
- First Posted Date
- 2013-08-07
- Last Posted Date
- 2024-06-18
- Lead Sponsor
- Organon and Co
- Target Recruit Count
- 608
- Registration Number
- NCT01918033
Efficacy and Safety Study of Desloratadine (MK-4117) in Japanese Participants With Eczema/Dermatitis and Dermal Pruritus (MK-4117-202)
- First Posted Date
- 2013-08-06
- Last Posted Date
- 2024-06-18
- Lead Sponsor
- Organon and Co
- Target Recruit Count
- 94
- Registration Number
- NCT01916980
An Efficacy and Safety Study of Desloratadine (MK-4117) in Japanese Participants With Chronic Urticaria (MK-4117-201)
- First Posted Date
- 2013-08-06
- Last Posted Date
- 2024-06-18
- Lead Sponsor
- Organon and Co
- Target Recruit Count
- 239
- Registration Number
- NCT01916967
Comparison of Desloratadine Associated With Prednisolone (Tablet)Versus Dexchlorpheniramine Associated With Betamethasone (Tablet) for Adult Persistent Allergic Rhinitis Treatment
- Conditions
- Allergic Rhinitis
- Interventions
- First Posted Date
- 2012-11-02
- Last Posted Date
- 2013-09-25
- Lead Sponsor
- EMS
- Target Recruit Count
- 234
- Registration Number
- NCT01720485
- Locations
- 🇧🇷
IMA - Instituto de Pesquisa Clínica e Medicina Avançada, São Paulo, Brazil
Comparison of Desloratadine Associated With Prednisolone Oral Solution Versus Dexchlorpheniramine Associated With Betamethasone for Cutaneous Rash Treatment
- Conditions
- Cutaneous Hypersensitivity
- Interventions
- First Posted Date
- 2012-02-08
- Last Posted Date
- 2017-02-16
- Lead Sponsor
- EMS
- Target Recruit Count
- 17
- Registration Number
- NCT01529242
- Locations
- 🇧🇷
Allergisa, Campinas, São Paulo, Brazil
🇧🇷Hospital Nipo Brasileiro, São Paulo, Brazil
🇧🇷Alergoalpha, São Paulo, SP, Brazil
Comparison of Desloratadine Associated With Prednisolone Oral Solution Versus Dexchlorpheniramine Associated With Betamethasone for Persistent Allergic Rhinitis Treatment
- Conditions
- Allergic Rhinitis
- Interventions
- First Posted Date
- 2012-02-08
- Last Posted Date
- 2015-01-15
- Lead Sponsor
- EMS
- Target Recruit Count
- 210
- Registration Number
- NCT01529229
Drug Development Updates
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