Vitamin E

Generic Name: Vitamin E

Brand Names: Mvc-fluoride, Vitafol-one

Drug Type: Small Molecule

Chemical Formula: C_₂₉H_₅₀O_₂

CAS Number: 59-02-9

Unique Ingredient Identifier: N9PR3490H9

Background: In 1922, vitamin E was demonstrated to be an essential nutrient. Vitamin E is a term used to describe 8 different fat soluble tocopherols and tocotrienols, alpha-tocopherol being the most biologically active. Vitamin E acts as an antioxidant, protecting cell membranes from oxidative damage. The antioxidant effects are currently being researched for use in th...

Indication: Vitamin E supplementation is indicated for treatment of vitamin E deficiency which can occur in cystic fibrosis, cholestasis and severe liver disease, abetalipoproteinemia or simply poor diet.

Associated Conditions: Vitamin Deficiency

Associated Therapies: Long-chain omega-3 fatty acid supplementation, Dietary supplementation

Clinical Trials

Ropinirole for the Treatment of Muscle Cramps in Patients With Cirrhosis

Phase 4

Completed

Conditions: Muscle Cramp
Cirrhosis

Interventions: Drug: Vitamin E
Drug: Ropinirole
Other: Muscle cramp survey

First Posted Date: 2017-06-06

Last Posted Date: 2022-10-31

Lead Sponsor: Vanderbilt University Medical Center

Target Recruit Count: 31

Registration Number: NCT03176966

Locations: 🇺🇸
Vanderbilt University Medical Center, Nashville, Tennessee, United States

The Impact of Pentoxifylline and Vitamin E on Radiotherapy-induced Toxicity in Head & Neck Cancer Patients

Phase 2

Completed

Conditions: Head and Neck Neoplasms

Interventions: Drug: Pentoxifylline
Drug: Vitamin E
Drug: Cisplatin
Radiation: Radiation therapy

First Posted Date: 2015-03-25

Last Posted Date: 2019-11-26

Lead Sponsor: Ain Shams University

Target Recruit Count: 60

Registration Number: NCT02397486

Locations: 🇪🇬
Ain Shams University Hospitals, Cairo, Egypt

Effect of Vitamin E Supplementation on Hemoglobin Levels in Healthy Adults

Phase 1

Completed

Conditions: Anemia

Interventions: Drug: placebo (edible oil)
Drug: Vitamin E

First Posted Date: 2014-07-03

Last Posted Date: 2014-07-03

Lead Sponsor: Aga Khan University

Target Recruit Count: 357

Registration Number: NCT02181348

Locations: 🇵🇰
Aga Khan University, Karachi, Sindh, Pakistan

Efficacy of Vitamin E in Preventing Contrast-Induced Acute Kidney Injury Following Coronary Angiography

Phase 3

Completed

Conditions: Stable Angina
Unstable Angina
Non ST Segment Elevation Myocardial Infarction
Post MI

Interventions: Drug: Vitamin E

First Posted Date: 2014-02-25

Last Posted Date: 2015-06-16

Lead Sponsor: Urmia University of Medical Sciences

Target Recruit Count: 284

Registration Number: NCT02070679

Locations: 🇮🇷
Taleghani Hospital, UMSU, Urmia, West-Azerbaijan, Iran, Islamic Republic of
🇮🇷
Seyyed-al-Shohada Heart Center, UMSU, Urmia, West-Azerbaijan, Iran, Islamic Republic of

Vitamin E Prevention of Visible Light Pigmentation

Not Applicable

Completed

Conditions: Pigmentation From Visible Light

Interventions: Drug: Vitamin E
Drug: Eucerin

First Posted Date: 2013-08-22

Last Posted Date: 2014-03-04

Lead Sponsor: Innovaderm Research Inc.

Target Recruit Count: 10

Registration Number: NCT01927679

Locations: 🇨🇦
Innovaderm Research Inc, Montreal, Quebec, Canada

Vitamin E Supplementation in Burned Patients

Phase 2

Completed

Conditions: Burn

Interventions: Drug: Vitamin E

First Posted Date: 2012-12-13

Last Posted Date: 2019-01-18

Lead Sponsor: The University of Texas Medical Branch, Galveston

Target Recruit Count: 31

Registration Number: NCT01749371

Locations: 🇺🇸
University of Texas Southwestern Medical Center, Parkland Health and Hospital System, Dallas, Texas, United States
🇺🇸
Memorial Hermann Hospital Burn Intensive Care Unit, Houston, Texas, United States
🇺🇸
University of Texas Medical Branch: Blocker Burn Unit and Shriners Hospitals for Children, Galveston, Texas, United States

Atorvastatin Versus Vitamin E in Treatment of Non-alcoholic Fatty Liver Disease

Phase 4

Conditions: Diabetes Mellitus
Dyslipidemias
Fatty Liver

Interventions: Drug: atorvastatin
Drug: Vitamin E

First Posted Date: 2012-11-02

Last Posted Date: 2016-02-03

Lead Sponsor: Xin Gao

Target Recruit Count: 120

Registration Number: NCT01720719

Locations: 🇨🇳
Department of Endocrinology and Metabolism, Zhongshan Hospital, Fudan University, Shanghai, Shanghai, China

Enhancing Treatment of Iron Deficiency and Iron Deficiency Anemia With an Antioxidant, Vitamin E

Phase 1

Completed

Conditions: Iron Deficiency
Iron Deficiency Anemia

Interventions: Drug: Vitamin E
Other: Placebo

First Posted Date: 2012-10-04

Last Posted Date: 2014-03-27

Lead Sponsor: University of Colorado, Denver

Target Recruit Count: 44

Registration Number: NCT01700426

Locations: 🇺🇸
University of Colorado Denver, Aurora, Colorado, United States

Multicenter Vitamin E Trial in Aging Persons With Down Syndrome

Phase 3

Completed

Conditions: Alzheimer's Disease
Down Syndrome

Interventions: Drug: Sugar Pill
Drug: Alpha-Tocopherol

First Posted Date: 2012-05-09

Last Posted Date: 2012-05-09

Lead Sponsor: New York State Institute for Basic Research

Target Recruit Count: 349

Registration Number: NCT01594346

Testosterone Pellets Plus Vitamin D and E Versus Vitamin D and E Alone for the Treatment of Peyronie's Disease

Phase 1

Completed

Conditions: Peyronie's Disease

Interventions: Drug: Testosterone Pellets
Drug: Vitamin D2
Drug: Vitamin E

First Posted Date: 2012-04-17

Last Posted Date: 2018-03-29

Lead Sponsor: Men's Health Boston

Target Recruit Count: 75

Registration Number: NCT01578473

Locations: 🇺🇸
Men's Health Boston, Chestnut Hill, Massachusetts, United States

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