Lepirudin
- Generic Name
- Lepirudin
- Brand Names
- -
- Drug Type
- Biotech
- Chemical Formula
- -
- CAS Number
- 138068-37-8
- Unique Ingredient Identifier
- Y43GF64R34
- Background
Lepirudin is a recombinant hirudin formed by 65 amino acids that acts as a highly specific and direct thrombin inhibitor. Natural hirudin is an endogenous anticoagulant found in Hirudo medicinalis leeches. Lepirudin is produced in yeast cells and is identical to natural hirudin except for the absence of sulfate on the tyrosine residue at position 63 and the ...
- Indication
Lepirudin is indicated for anticoagulation in adult patients with acute coronary syndromes (ACS) such as unstable angina and acute myocardial infarction without ST elevation. In patients with ACS, lepirudin is intended for use with aspirin. Lepirudin is also indicated for anticoagulation in patients with heparin-induced thrombocytopenia (HIT) and associated ...
- Associated Conditions
- -
- Associated Therapies
- Anticoagulation
Study Evaluation of Recombinant Hirudin in Prophylaxis of Post-Operative Deep Vein Thrombosis
- First Posted Date
- 2023-05-06
- Last Posted Date
- 2023-05-06
- Lead Sponsor
- MinaPharm Pharmaceuticals
- Target Recruit Count
- 100
- Registration Number
- NCT05847205
- Locations
- 🇪🇬
Alexandria University, Alexandria, Egypt
Retrospective Registry of Patients With Acute Heparin-induced Thrombocytopenia Type II
- Conditions
- Interventions
- First Posted Date
- 2011-02-25
- Last Posted Date
- 2017-07-06
- Lead Sponsor
- GlaxoSmithKline
- Target Recruit Count
- 195
- Registration Number
- NCT01304238
Argatroban Versus Lepirudin in Critically Ill Patients
- Conditions
- Interventions
- First Posted Date
- 2008-11-26
- Last Posted Date
- 2012-06-21
- Lead Sponsor
- Heinrich-Heine University, Duesseldorf
- Target Recruit Count
- 70
- Registration Number
- NCT00798525
- Locations
- 🇩🇪
Universitätsklinikum Düsseldorf Klinik für Anästhesiologie, Düsseldorf, Germany
Heparin Versus Lepirudin Flushes in Preventing Blockage of Venous Access Devices
- Conditions
- First Posted Date
- 2002-06-10
- Last Posted Date
- 2008-03-04
- Target Recruit Count
- 340
- Registration Number
- NCT00039767
- Locations
- 🇺🇸
National Institutes of Health Clinical Center (CC), Bethesda, Maryland, United States
Drug Development Updates
Stay informed with timely notifications on clinical trials, regulatory changes, and research advancements related to this medication.