Ritonavir

Generic Name
Ritonavir
Brand Names
Kaletra, Norvir, Paxlovid, Viekira Pak, Ritonavir Mylan
Drug Type
Small Molecule
Chemical Formula
C37H48N6O5S2
CAS Number
155213-67-5
Unique Ingredient Identifier
O3J8G9O825
Background

Ritonavir is an HIV protease inhibitor that interferes with the reproductive cycle of HIV. Although it was initially developed as an independent antiviral agent, it has been shown to possess advantageous properties in combination regimens with low-dose ritonavir and other protease inhibitors. It is now more commonly used as a booster of other protease inhibi...

Indication

Ritonavir is indicated in combination with other antiretroviral agents for the treatment of HIV-1 infection.
...

Associated Conditions
Chronic hepatitis C genotype 1a, Chronic hepatitis C genotype 1b, Human Immunodeficiency Virus Type 1 (HIV-1) Infection, Mild, moderate Novel Coronavirus Infectious Disease (COVID-19)
Associated Therapies
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BMS-Reyataz Study in Treatment in Naive Subjects to Compare the Efficacy and Safety Between Boosted Reyataz and Kaletra When in Combination With Fixed Dose Truvada

First Posted Date
2006-01-09
Last Posted Date
2011-05-09
Lead Sponsor
Bristol-Myers Squibb
Target Recruit Count
1057
Registration Number
NCT00272779
Locations
🇬🇧

Local Institution, Manchester, Greater Manchester, United Kingdom

Blood Levels of Anti-HIV Drugs Used in Combination Regimens in HIV Infected Children

First Posted Date
2005-12-01
Last Posted Date
2021-11-09
Lead Sponsor
National Institute of Allergy and Infectious Diseases (NIAID)
Target Recruit Count
75
Registration Number
NCT00260078
Locations
🇺🇸

Rush Univ. Cook County Hosp. Chicago NICHD CRS, Chicago, Illinois, United States

🇺🇸

Ann & Robert H. Lurie Children's Hospital of Chicago (LCH) CRS, Chicago, Illinois, United States

🇺🇸

Children's Hosp. of Boston NICHD CRS, Boston, Massachusetts, United States

and more 20 locations

GW640385 Plus Ritonavir And NRTIs For 48 Weeks In HIV-1 Infected Adults

First Posted Date
2005-11-23
Last Posted Date
2017-05-30
Lead Sponsor
ViiV Healthcare
Target Recruit Count
30
Registration Number
NCT00257621
Locations
🇺🇸

GSK Investigational Site, Seattle, Washington, United States

Boosted Atazanavir and Truvada Given Once-Daily - BATON Study

Phase 4
Completed
Conditions
Interventions
First Posted Date
2005-09-23
Last Posted Date
2013-01-10
Lead Sponsor
Gilead Sciences
Target Recruit Count
100
Registration Number
NCT00224445
Locations
🇺🇸

Gilead Sciences, Inc., Foster City, California, United States

HIV Infection And Metabolic Abnormalities Protocol 1 (HAMA001)

First Posted Date
2005-09-19
Last Posted Date
2012-04-12
Lead Sponsor
Kirby Institute
Target Recruit Count
80
Registration Number
NCT00192660
Locations
🇦🇺

St. Vincent's Hospital, Sydney, New South Wales, Australia

Evaluation of Therapeutic Drug Monitoring of Protease Inhibitors on Virologic Success and Tolerance of Highly Active Antiretroviral Therapy (HAART)

Not Applicable
Terminated
Conditions
First Posted Date
2005-07-22
Last Posted Date
2005-08-01
Lead Sponsor
French National Agency for Research on AIDS and Viral Hepatitis
Target Recruit Count
115
Registration Number
NCT00122590
Locations
🇫🇷

Service de Medecine Interne Hopital Cochin, Paris, France

Efficacy and Safety of Tenofovir DF/Atazanavir Enhanced With Low Dose of Ritonavir in HIV-Infected Patients

Phase 2
Terminated
Conditions
First Posted Date
2005-07-22
Last Posted Date
2005-07-28
Lead Sponsor
French National Agency for Research on AIDS and Viral Hepatitis
Target Recruit Count
50
Registration Number
NCT00122577
Locations
🇫🇷

Service d'Immunologie clinique Hopital Europeen Georges Pompidou, Paris, France

Efficacy and Tolerability of an Antiretroviral Bi-Therapy in HIV Infected Patients With Multidrug Resistance

Phase 2
Terminated
Conditions
First Posted Date
2005-07-19
Last Posted Date
2007-01-18
Lead Sponsor
French National Agency for Research on AIDS and Viral Hepatitis
Target Recruit Count
40
Registration Number
NCT00120783
Locations
🇫🇷

Service de Medecine Interne hopital Avicenne, Bobigny, France

Efavirenz or Atazanavir/Ritonavir Given With Emtricitabine/Tenofovir Disoproxil Fumarate or Abacavir/Lamivudine in HIV Infected Treatment-Naive Adults

First Posted Date
2005-07-12
Last Posted Date
2018-10-12
Lead Sponsor
Advancing Clinical Therapeutics Globally for HIV/AIDS and Other Infections
Target Recruit Count
1864
Registration Number
NCT00118898
Locations
🇺🇸

Univ of Iowa Hosp and Clinic (1504), Iowa City, Iowa, United States

🇺🇸

Vanderbilt Therapeutics CRS (3652), Nashville, Tennessee, United States

🇺🇸

SUNY - Buffalo (Rochester) (1102), Buffalo, New York, United States

and more 49 locations
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