Ritonavir

Generic Name
Ritonavir
Brand Names
Kaletra, Norvir, Paxlovid, Viekira Pak, Ritonavir Mylan
Drug Type
Small Molecule
Chemical Formula
C37H48N6O5S2
CAS Number
155213-67-5
Unique Ingredient Identifier
O3J8G9O825
Background

Ritonavir is an HIV protease inhibitor that interferes with the reproductive cycle of HIV. Although it was initially developed as an independent antiviral agent, it has been shown to possess advantageous properties in combination regimens with low-dose ritonavir and other protease inhibitors. It is now more commonly used as a booster of other protease inhibi...

Indication

Ritonavir is indicated in combination with other antiretroviral agents for the treatment of HIV-1 infection.
...

Associated Conditions
Chronic hepatitis C genotype 1a, Chronic hepatitis C genotype 1b, Human Immunodeficiency Virus Type 1 (HIV-1) Infection, Mild, moderate Novel Coronavirus Infectious Disease (COVID-19)
Associated Therapies
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A Randomized Trial of the Efficacy and Safety of a Strategy of Starting With Nelfinavir Versus Ritonavir Added to Background Antiretroviral (AR) Nucleoside Therapy in HIV-Infected Individuals With CD4+ Cell Counts Less Than or Equal to 200/mm3

Not Applicable
Completed
Conditions
First Posted Date
2001-08-31
Last Posted Date
2021-10-29
Lead Sponsor
National Institute of Allergy and Infectious Diseases (NIAID)
Target Recruit Count
1300
Registration Number
NCT00000859
Locations
🇺🇸

AIDS Research Consortium of Atlanta, Atlanta, Georgia, United States

🇺🇸

AIDS Research Alliance - Chicago, Chicago, Illinois, United States

🇺🇸

Baltimore TRIALS, Baltimore, Maryland, United States

and more 40 locations

A Study of Ritonavir (an Anti-HIV Drug) in HIV-Positive Infants and Children

Phase 1
Completed
Conditions
First Posted Date
2001-08-31
Last Posted Date
2021-10-29
Lead Sponsor
National Institute of Allergy and Infectious Diseases (NIAID)
Target Recruit Count
60
Registration Number
NCT00000952
Locations
🇺🇸

Harlem Hosp. Ctr. NY NICHD CRS, New York, New York, United States

🇺🇸

The Children's Hosp. of Philadelphia IMPAACT CRS, Philadelphia, Pennsylvania, United States

🇺🇸

HMS - Children's Hosp. Boston, Div. of Infectious Diseases, Boston, Massachusetts, United States

and more 9 locations

Safety and Effectiveness of Ritonavir Plus Lamivudine Plus Zidovudine in HIV-Infected Pregnant Women and Their Babies

Phase 1
Completed
Conditions
First Posted Date
2001-08-31
Last Posted Date
2021-10-29
Lead Sponsor
National Institute of Allergy and Infectious Diseases (NIAID)
Target Recruit Count
14
Registration Number
NCT00000888
Locations
🇺🇸

Children's Hospital of Michigan NICHD CRS, Detroit, Michigan, United States

🇺🇸

Univ. of Miami Miller School of Medicine - Jackson Memorial Hosp., Miami, Florida, United States

🇺🇸

Univ. of Miami Ped. Perinatal HIV/AIDS CRS, Miami, Florida, United States

and more 2 locations
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