Ritonavir

Generic Name
Ritonavir
Brand Names
Kaletra, Norvir, Paxlovid, Viekira Pak, Ritonavir Mylan
Drug Type
Small Molecule
Chemical Formula
C37H48N6O5S2
CAS Number
155213-67-5
Unique Ingredient Identifier
O3J8G9O825
Background

Ritonavir is an HIV protease inhibitor that interferes with the reproductive cycle of HIV. Although it was initially developed as an independent antiviral agent, it has been shown to possess advantageous properties in combination regimens with low-dose ritonavir and other protease inhibitors. It is now more commonly used as a booster of other protease inhibi...

Indication

Ritonavir is indicated in combination with other antiretroviral agents for the treatment of HIV-1 infection.
...

Associated Conditions
Chronic hepatitis C genotype 1a, Chronic hepatitis C genotype 1b, Human Immunodeficiency Virus Type 1 (HIV-1) Infection, Mild, moderate Novel Coronavirus Infectious Disease (COVID-19)
Associated Therapies
-

A Study on the Management of Combination Anti-HIV Drug Therapy in HIV-Positive Children With Prior Treatment

Phase 1
Completed
Conditions
First Posted Date
2001-08-31
Last Posted Date
2021-10-29
Lead Sponsor
National Institute of Allergy and Infectious Diseases (NIAID)
Target Recruit Count
217
Registration Number
NCT00000902
Locations
🇺🇸

Connecticut Children's Med Ctr, Farmington, Connecticut, United States

🇺🇸

Cedars Sinai / UCLA Med Ctr, Los Angeles, California, United States

🇺🇸

Harbor - UCLA Med Ctr / UCLA School of Medicine, Los Angeles, California, United States

and more 59 locations

Comparison of New Anti-HIV Drug Combinations in HIV-Infected Children Who Have Taken Anti-HIV Drugs

Phase 2
Completed
Conditions
First Posted Date
2001-08-31
Last Posted Date
2021-11-04
Lead Sponsor
National Institute of Allergy and Infectious Diseases (NIAID)
Target Recruit Count
240
Registration Number
NCT00001083
Locations
🇺🇸

Harbor - UCLA Med Ctr / UCLA School of Medicine, Los Angeles, California, United States

🇺🇸

Univ of Miami (Pediatric), Miami, Florida, United States

🇺🇸

North Shore Univ Hosp, Great Neck, New York, United States

and more 58 locations

A Study of the Safety and Effectiveness of Treating Advanced AIDS Patients Between Ages 4 and 22 With 7 Drugs, Some at Higher Than Usual Doses

Phase 1
Completed
Conditions
First Posted Date
2001-08-31
Last Posted Date
2021-11-01
Lead Sponsor
National Institute of Allergy and Infectious Diseases (NIAID)
Target Recruit Count
6
Registration Number
NCT00001108
Locations
🇺🇸

Cook County Hosp, Chicago, Illinois, United States

🇺🇸

Univ of Massachusetts Med School, Worcester, Massachusetts, United States

🇺🇸

Univ of Mississippi Med Ctr, Jackson, Mississippi, United States

and more 16 locations

Evaluation of Specific Infection-Fighting Cells For Prediction of Immune Response to Anti-HIV and Immune-Boosting Medication

Not Applicable
Withdrawn
Conditions
First Posted Date
2001-08-31
Last Posted Date
2015-03-09
Lead Sponsor
National Institute of Allergy and Infectious Diseases (NIAID)
Registration Number
NCT00006578
Locations
🇺🇸

Univ of Colorado Health Sciences Ctr, Denver, Colorado, United States

🇺🇸

Univ of Miami School of Medicine, Miami, Florida, United States

🇺🇸

Northwestern Univ Med School, Chicago, Illinois, United States

and more 2 locations

Interactions of HIV Protease Inhibitors and Methadone in HIV-Infected Patients

Phase 1
Completed
Conditions
First Posted Date
2001-08-31
Last Posted Date
2021-11-04
Lead Sponsor
National Institute of Allergy and Infectious Diseases (NIAID)
Target Recruit Count
12
Registration Number
NCT00000906
Locations
🇺🇸

Johns Hopkins Hosp, Baltimore, Maryland, United States

🇺🇸

San Francisco Gen Hosp, San Francisco, California, United States

🇺🇸

Univ of Colorado Health Sciences Ctr, Denver, Colorado, United States

and more 4 locations

Effects on the Immune System of Anti-HIV Drugs in Patients Recently Infected With HIV

Not Applicable
Completed
Conditions
First Posted Date
2001-08-31
Last Posted Date
2011-03-02
Lead Sponsor
National Institute of Allergy and Infectious Diseases (NIAID)
Target Recruit Count
288
Registration Number
NCT00001119
Locations
🇺🇸

Seattle HIVNET, Seattle, Washington, United States

🇺🇸

Univ of Washington, Seattle, Washington, United States

🇺🇸

Univ of Minnesota, Minneapolis, Minnesota, United States

and more 9 locations

A Study of Several Anti-HIV Drug Combinations in HIV-Infected Patients Who Have Used Indinavir

Not Applicable
Completed
Conditions
First Posted Date
2001-08-31
Last Posted Date
2021-11-04
Lead Sponsor
National Institute of Allergy and Infectious Diseases (NIAID)
Target Recruit Count
300
Registration Number
NCT00000892
Locations
🇺🇸

Cornell Univ Med Ctr, New York, New York, United States

🇺🇸

Mount Sinai Med Ctr, New York, New York, United States

🇺🇸

Univ of Tennessee / E Tennessee Comprehensive Hemophilia Ctr, Knoxville, Tennessee, United States

and more 42 locations

A Study to Compare Two Different Anti-HIV Drug Regimens

Phase 2
Completed
Conditions
First Posted Date
2001-08-31
Last Posted Date
2021-10-29
Lead Sponsor
National Institute of Allergy and Infectious Diseases (NIAID)
Target Recruit Count
120
Registration Number
NCT00000924
Locations
🇺🇸

Harbor - UCLA Med Ctr / UCLA School of Medicine, Los Angeles, California, United States

🇺🇸

Cook County Hosp, Chicago, Illinois, United States

🇺🇸

Chicago Children's Memorial Hosp, Chicago, Illinois, United States

and more 42 locations

The Effects of Staggered Dosing on Interactions Between Paired Combinations of Nelfinavir, Ritonavir, and Saquinavir

Not Applicable
Completed
Conditions
First Posted Date
2001-08-31
Last Posted Date
2021-10-29
Lead Sponsor
National Institute of Allergy and Infectious Diseases (NIAID)
Target Recruit Count
18
Registration Number
NCT00000898
Locations
🇺🇸

Univ of California/ San Francisco / Dept of Medicine, San Francisco, California, United States

🇺🇸

Stanford Univ Med Ctr, Stanford, California, United States

🇺🇸

San Francisco Gen Hosp, San Francisco, California, United States

and more 1 locations

Atazanavir Used in Combination With Other Anti-HIV Drugs in HIV-Infected Infants, Children, and Adolescents

Phase 1
Completed
Conditions
Interventions
First Posted Date
2001-08-31
Last Posted Date
2021-11-05
Lead Sponsor
National Institute of Allergy and Infectious Diseases (NIAID)
Target Recruit Count
195
Registration Number
NCT00006604
Locations
🇺🇸

Rush Univ. Cook County Hosp. Chicago NICHD CRS, Chicago, Illinois, United States

🇺🇸

Children's Med. Ctr. Dallas, Dallas, Texas, United States

🇺🇸

Univ. of California San Francisco NICHD CRS, San Francisco, California, United States

and more 33 locations
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