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Thiamine

Generic Name
Thiamine
Brand Names
Alertonic, Concept Ob, Fortaplex, Infuvite, Infuvite Pediatric, Irospan 24/6 Kit, Mvc-fluoride, Mvi Pediatric, Natafort, Neo-bex, Pregvit, Tandem Plus, Vitafol-one
Drug Type
Small Molecule
Chemical Formula
C12H17N4OS
CAS Number
70-16-6
Unique Ingredient Identifier
4ABT0J945J

Overview

Thiamine or thiamin, also known as vitamin B1, is a colorless compound with the chemical formula C12H17N4OS. It is soluble in water and insoluble in alcohol. Thiamine decomposes if heated. Thiamine was first discovered by Umetaro Suzuki in Japan when researching how rice bran cured patients of Beriberi. Thiamine plays a key role in intracellular glucose metabolism and it is thought that thiamine inhibits the effect of glucose and insulin on arterial smooth muscle cell proliferation. Thiamine plays an important role in helping the body convert carbohydrates and fat into energy. It is essential for normal growth and development and helps to maintain proper functioning of the heart and the nervous and digestive systems. Thiamine cannot be stored in the body; however, once absorbed, the vitamin is concentrated in muscle tissue.

Background

Thiamine or thiamin, also known as vitamin B1, is a colorless compound with the chemical formula C12H17N4OS. It is soluble in water and insoluble in alcohol. Thiamine decomposes if heated. Thiamine was first discovered by Umetaro Suzuki in Japan when researching how rice bran cured patients of Beriberi. Thiamine plays a key role in intracellular glucose metabolism and it is thought that thiamine inhibits the effect of glucose and insulin on arterial smooth muscle cell proliferation. Thiamine plays an important role in helping the body convert carbohydrates and fat into energy. It is essential for normal growth and development and helps to maintain proper functioning of the heart and the nervous and digestive systems. Thiamine cannot be stored in the body; however, once absorbed, the vitamin is concentrated in muscle tissue.

Indication

For the treatment of thiamine and niacin deficiency states, Korsakov's alcoholic psychosis, Wernicke-Korsakov syndrome, delirium, and peripheral neuritis.

Associated Conditions

  • Anemia
  • B12 Deficiency Anemia
  • Beriberi
  • Cardiovascular Heart Disease caused by Thiamine Deficiency
  • Folic Acid Deficiency Anemia
  • Infantile Beriberi
  • Infection
  • Iron Deficiency (ID)
  • Neuritis caused by Pregnancy
  • Secondary anemia
  • Thiamine Deficiency
  • Vitamin Deficiency
  • Wernicke's encephalopathy
  • Liver disorders

FDA Drug Approvals

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Approved Product
Manufacturer
NDC Code
Route
Strength
Effective Date
Cameron Pharmaceuticals
42494-432
ORAL
1 mg in 1 1
9/18/2023
Mylan Institutional LLC
67457-196
INTRAMUSCULAR, INTRAVENOUS
100 mg in 1 mL
1/24/2017
Carilion Materials Management
68151-2640
ORAL
1.84 mg in 1 1
4/1/2013
Trivia Pharmaceuticals, LLC
84781-012
ORAL
3 mg in 1 1
6/23/2025
PureTek Corporation
59088-112
ORAL
10 mg in 1 1
1/11/2023
WINDER LABORATORIES, LLC
75826-171
ORAL
1.05 mg in 1 1
1/31/2024
Lupin Pharmaceuticals, Inc.
70748-347
INTRAMUSCULAR, INTRAVENOUS
100 mg in 1 mL
12/14/2023
PureTek Corporation
59088-695
ORAL
1.05 mg in 1 1
12/13/2023
ONESOURCE SPECIALTY PHARMA LIMITED
83270-004
INTRAVENOUS, INTRAMUSCULAR
100 mg in 1 mL
11/11/2024
Novian Pharmaceuticals
83146-003
ORAL
3 mg in 1 1
10/6/2023

EMA Drug Approvals

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Approved Product
Authorization Holder
Status
Issued Date
No EMA approvals found for this drug.

HSA Drug Approvals

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Approved Product
Manufacturer
Approval Number
Dosage Form
Strength
Approval Date
DANEURON TABLET
SIN12077P
TABLET, FILM COATED
100 mg
9/17/2002
FBC FILMTAB
SIN05814P
TABLET, FILM COATED
2 mg
5/3/1991
NEURO-B TABLET
SIN10891P
TABLET, FILM COATED
100 mg
4/23/1999
SOLUVIT N FOR INFUSION
SIN05209P
INJECTION, POWDER, FOR SOLUTION
3.1mg /vial
11/14/1990

NMPA Drug Approvals

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Approved Product
Company
Approval Number
Drug Type
Dosage Form
Approval Date
No NMPA approvals found for this drug.

PPB Drug Approvals

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Approved Product
Registration No.
Company
Licence No.
Strength
Registration Date
COMYLLONE CAP
N/A
vickmans laboratories ltd
N/A
N/A
11/27/1998
PANTOGAR CAP
N/A
N/A
N/A
4/17/2002

TGA Drug Approvals

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