Overview
Thiamine or thiamin, also known as vitamin B1, is a colorless compound with the chemical formula C12H17N4OS. It is soluble in water and insoluble in alcohol. Thiamine decomposes if heated. Thiamine was first discovered by Umetaro Suzuki in Japan when researching how rice bran cured patients of Beriberi. Thiamine plays a key role in intracellular glucose metabolism and it is thought that thiamine inhibits the effect of glucose and insulin on arterial smooth muscle cell proliferation. Thiamine plays an important role in helping the body convert carbohydrates and fat into energy. It is essential for normal growth and development and helps to maintain proper functioning of the heart and the nervous and digestive systems. Thiamine cannot be stored in the body; however, once absorbed, the vitamin is concentrated in muscle tissue.
Indication
For the treatment of thiamine and niacin deficiency states, Korsakov's alcoholic psychosis, Wernicke-Korsakov syndrome, delirium, and peripheral neuritis.
Associated Conditions
- Anemia
- B12 Deficiency Anemia
- Beriberi
- Cardiovascular Heart Disease caused by Thiamine Deficiency
- Folic Acid Deficiency Anemia
- Infantile Beriberi
- Infection
- Iron Deficiency (ID)
- Neuritis caused by Pregnancy
- Secondary anemia
- Thiamine Deficiency
- Vitamin Deficiency
- Wernicke's encephalopathy
- Liver disorders
Clinical Trials
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Title | Posted | Study ID | Phase | Status | Sponsor |
|---|---|---|---|---|---|
2019/06/18 | Phase 3 | UNKNOWN | |||
2018/08/28 | Not Applicable | UNKNOWN | Universiti Kebangsaan Malaysia Medical Centre | ||
2018/08/16 | Phase 4 | Completed | |||
2018/08/13 | N/A | Completed | |||
2018/07/19 | Phase 2 | Completed | Trinity Health Of New England | ||
2018/06/08 | Phase 2 | Completed | |||
2018/04/26 | Phase 3 | Completed | |||
2018/04/26 | Phase 2 | Completed | Amsterdam UMC, location VUmc | ||
2018/03/01 | Phase 2 | Terminated | Michael Donnino | ||
2018/02/14 | Early Phase 1 | Completed |
FDA Drug Approvals
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Approved Product | Manufacturer | NDC Code | Route | Strength | Effective Date |
|---|---|---|---|---|---|
| Cameron Pharmaceuticals | 42494-432 | ORAL | 1 mg in 1 1 | 9/18/2023 | |
| Mylan Institutional LLC | 67457-196 | INTRAMUSCULAR, INTRAVENOUS | 100 mg in 1 mL | 1/24/2017 | |
| Carilion Materials Management | 68151-2640 | ORAL | 1.84 mg in 1 1 | 4/1/2013 | |
| Trivia Pharmaceuticals, LLC | 84781-012 | ORAL | 3 mg in 1 1 | 6/23/2025 | |
| PureTek Corporation | 59088-112 | ORAL | 10 mg in 1 1 | 1/11/2023 | |
| WINDER LABORATORIES, LLC | 75826-171 | ORAL | 1.05 mg in 1 1 | 8/27/2025 | |
| Lupin Pharmaceuticals, Inc. | 70748-347 | INTRAMUSCULAR, INTRAVENOUS | 100 mg in 1 mL | 12/14/2023 | |
| PureTek Corporation | 59088-695 | ORAL | 1.05 mg in 1 1 | 12/13/2023 | |
| ONESOURCE SPECIALTY PHARMA LIMITED | 83270-004 | INTRAVENOUS, INTRAMUSCULAR | 100 mg in 1 mL | 11/11/2024 | |
| Novian Pharmaceuticals | 83146-003 | ORAL | 3 mg in 1 1 | 10/6/2023 |
EMA Drug Approvals
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Approved Product | Authorization Holder | Status | Issued Date |
|---|---|---|---|
| No EMA approvals found for this drug. | |||
HSA Drug Approvals
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Approved Product | Manufacturer | Approval Number | Dosage Form | Strength | Approval Date |
|---|---|---|---|---|---|
| DANEURON TABLET | SIN12077P | TABLET, FILM COATED | 100 mg | 9/17/2002 | |
| FBC FILMTAB | SIN05814P | TABLET, FILM COATED | 2 mg | 5/3/1991 | |
| NEURO-B TABLET | SIN10891P | TABLET, FILM COATED | 100 mg | 4/23/1999 | |
| SOLUVIT N FOR INFUSION | SIN05209P | INJECTION, POWDER, FOR SOLUTION | 3.1mg /vial | 11/14/1990 |
NMPA Drug Approvals
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|---|---|---|---|---|---|
| No NMPA approvals found for this drug. | |||||
PPB Drug Approvals
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Approved Product | Registration No. | Company | Licence No. | Strength | Registration Date |
|---|---|---|---|---|---|
| COMYLLONE CAP | N/A | N/A | N/A | 11/27/1998 | |
| PANTOGAR CAP | N/A | N/A | N/A | 4/17/2002 | |
| MULTIMAX SYRUP | N/A | N/A | N/A | 7/8/2014 |
TGA Drug Approvals
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Approved Product | ARTG ID | Sponsor | Registration Type | Status | Registration Date |
|---|---|---|---|---|---|
| Herbsense Zinc Vitamin B Plus | 279921 | Medicine | A | 9/5/2016 | |
| Threshold Controlled B-Complex | 276600 | Medicine | A | 6/15/2016 | |
| Biogency Multi-B Capsules | 362318 | Medicine | A | 4/16/2021 | |
| HKSG Swisse Kids Multi | 321304 | Medicine | A | 8/5/2019 | |
| USANA HealthPak | 350153 | Medicine | A | 11/30/2020 | |
| Supervite Multivitamin + Ginseng | 312495 | Medicine | A | 12/13/2018 | |
| Sugar Balance | 314136 | Medicine | A | 2/11/2019 | |
| Ultra Muscleze Forest Berries | 305454 | Medicine | A | 6/27/2018 | |
| Mega Lifesciences Lysine with Multivitamins Chewable Tablet | 304262 | Medicine | A | 6/13/2018 | |
| METAGENICS ENERGYX TROPICAL FLAVOUR | 343670 | Medicine | A | 9/17/2020 |
Health Canada Drug Approvals
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Approved Product | Company | DIN | Dosage Form | Strength | Market Date |
|---|---|---|---|---|---|
| ONE PER DAY OMNIPLEX WITH BETA CAROTENE-TAB | vita health products inc | 02135795 | Tablet - Oral | 10 MG | 10/11/1996 |
| ADAPTAGEN | bio active canada ltd. | 02233546 | Liquid - Oral | 4 X | 5/26/1998 |
| TWIN PRO POWDER VANILLA | twin laboratories inc. | 02014149 | Powder - Oral | .525 MG / 71.35 G | 12/31/1995 |
| FUSION AM FORMULA TAB | l & s research corporation | 01961152 | Tablet - Oral | 5 MG / TAB | 12/31/1993 |
| HEMAREXIN LIQ | lab bio chimique inc.,division of technilab pharma inc. | 01922742 | Liquid - Oral | .5 MG / 5 ML | 12/22/1993 |
| FORMULA V S C TAB | creative nutrition canada corp. | 01963899 | Tablet - Oral | 2 MG / TAB | 12/31/1994 |
| B-100 HI POTENCY B VITAMINS TAB | natrol, inc. | 02060256 | Tablet - Oral | 100 MG | 12/31/1994 |
| GRAND MASTER FORMULA TAB | nutrition for life international | 02053349 | Tablet - Oral | 10 MG | 12/30/1996 |
| B-COMPLEX | enrich international | 02238709 | Tablet - Oral | 12.5 MG / TAB | 11/11/1999 |
| B 50 CAPSULES | rheingold food international ltd. | 00643041 | Capsule - Oral | 50 MG / CAP | 12/31/1987 |
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| No CIMA AEMPS (Spain) approvals found for this drug. | |||||
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| No Philippines FDA approvals found for this drug. | |||||
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| No UK EMC drug information found for this drug. | |||||
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